INT79459

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Context Info
Confidence 1.00
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.09
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkca) endoplasmic reticulum (Prkca) enzyme binding (Prkca)
protein complex (Prkca) cytoplasm (Prkca) cytosol (Prkca)
Prkca (Mus musculus)
Pain Link Frequency Relevance Heat
fluoxetine 7 98.32 Very High Very High Very High
agonist 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperplasia 1 85.20 High High
Cancer 7 5.00 Very Low Very Low Very Low
Ocular Toxicity (including Many Sub-types) 5 5.00 Very Low Very Low Very Low
Diabetic Retinopathy 5 5.00 Very Low Very Low Very Low
Retinal Neovascularization 3 5.00 Very Low Very Low Very Low
Hypoxia 2 5.00 Very Low Very Low Very Low
Skin Cancer 2 5.00 Very Low Very Low Very Low
Glaucoma 2 5.00 Very Low Very Low Very Low
Pathologic Neovascularization 2 5.00 Very Low Very Low Very Low
Colon Cancer 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We observed that fluoxetine increased PKC translocation obtained with 1 microg/mL Con A concentration, whereas PKC was degraded when 2 microg/mL was used.
Protein_catabolism (degraded) of PKC associated with fluoxetine
1) Confidence 1.00 Published 1998 Journal Cell. Signal. Section Abstract Doc Link 9884023 Disease Relevance 0.09 Pain Relevance 0.60
There are a number of splicing factor kinases that are activated by PKC, including the SR protein kinases SRPK1 and SRPK2 (20, 21).
Protein_catabolism (by) of PKC
2) Confidence 0.17 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0

General Comments

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