INT79477

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Context Info
Confidence 0.26
First Reported 1999
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 19
Total Number 20
Disease Relevance 13.78
Pain Relevance 3.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HLA-DMA) intracellular (HLA-DMA) protein complex assembly (HLA-DMA)
Anatomy Link Frequency
T cells 2
plasma 1
leukocyte 1
liver 1
arm 1
HLA-DMA (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 138 100.00 Very High Very High Very High
Arthritis 409 99.48 Very High Very High Very High
spinal inflammation 22 99.48 Very High Very High Very High
lidocaine 1 98.10 Very High Very High Very High
cytokine 15 92.00 High High
chemokine 3 91.92 High High
Inflammation 62 91.60 High High
Bioavailability 129 86.64 High High
backache 4 78.32 Quite High
Inflammatory response 10 78.24 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 139 100.00 Very High Very High Very High
Diabetes Complications 24 99.60 Very High Very High Very High
Juvenile Chronic Polyarthritis 328 99.48 Very High Very High Very High
Low Back Pain 6 99.48 Very High Very High Very High
Autoimmune Disease 29 99.44 Very High Very High Very High
Hypergammaglobulinemia 2 99.34 Very High Very High Very High
Testicular Cancer 294 99.00 Very High Very High Very High
Disease 347 98.28 Very High Very High Very High
Diabetes Mellitus 213 97.60 Very High Very High Very High
Autoimmune Hepatitis 169 97.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The Human Major Histocompatibility Antigens (HLA) are generally cell bound, but trace amounts exist in soluble forms which circulate in serum, plasma, and other human body fluids [1].
HLA Binding (bound) of in plasma
1) Confidence 0.26 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC1939839 Disease Relevance 0.30 Pain Relevance 0.03
Determination of MTDI values based solely on the total As concentration in rice may significantly overestimate As intake for varieties containing a high proportion of DMA.
DMA Binding (proportion) of
2) Confidence 0.21 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1764129 Disease Relevance 0 Pain Relevance 0.13
Conversely, inclusion of only the inorganic As concentration in MTDI calculations would underestimate As intake for varieties containing a high proportion of DMA.
DMA Binding (proportion) of
3) Confidence 0.21 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1764129 Disease Relevance 0 Pain Relevance 0.16
In addition, we assessed the accuracy of the As speciation method by analyzing As standard solutions (MMA, DMA, AsIII, and AsV; 100 ?
DMA Binding (solutions) of in MMA
4) Confidence 0.21 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1764129 Disease Relevance 0 Pain Relevance 0
Given the strong association with HLA-risk genotypes we can not rule out that they are part of a same haplotype and their risk on disease can therefore only be judged from studies assessing them all.


HLA Binding (association) of associated with disease
5) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429972 Disease Relevance 0.61 Pain Relevance 0.13
It produced a striking negative effect on binding by 2,6-DMA, decreasing the adduct level by 78%.
DMA Binding (binding) of
6) Confidence 0.09 Published 2010 Journal Carcinogenesis Section Body Doc Link PMC2802674 Disease Relevance 0 Pain Relevance 0
The association patterns between diabetic complications and polymorphisms in LTA, TNF, AGER and HLA was complex and none of the studied polymorphism was associated with all diabetic complications in either type 1 or type 2 diabetic patients.
HLA Binding (associated) of associated with diabetes mellitus and diabetes complications
7) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429972 Disease Relevance 1.15 Pain Relevance 0
Several candidate genes on the short arm of chromosome 6 including the HLA locus, TNF, LTA and AGER could be associated with late diabetic complications.
HLA Binding (associated) of in arm associated with diabetes complications
8) Confidence 0.08 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2429972 Disease Relevance 0.42 Pain Relevance 0
As peptide presentation by HLA molecules is of central importance for immune responses, we performed thermodynamic (circular dichroism, differential scanning calorimetry, fluorescence polarization) and X-ray crystallographic analyses of both HLA-B27 subtypes complexed with the epidermal growth factor response factor 1-derived self-peptide TIS (RRLPIFSRL) to understand the impact of the Asp116His exchange on peptide display.
HLA Binding (presentation) of
9) Confidence 0.08 Published 2005 Journal J. Mol. Biol. Section Abstract Doc Link 15713487 Disease Relevance 0.20 Pain Relevance 0.10
JIA type with negative RF is heterogeneous and HLA associations are not so distinct as of other types.
HLA Binding (associations) of associated with arthritis
10) Confidence 0.05 Published 2010 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2964715 Disease Relevance 2.02 Pain Relevance 0.82
Different studies have shown that there exists association between HLA genes and certain JIA types [8].
HLA Binding (association) of associated with arthritis
11) Confidence 0.05 Published 2010 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2964715 Disease Relevance 1.39 Pain Relevance 0.58
Drugs like sulfamethoxazole (SMX) or lidocaine can be presented to specific human alphabeta+ T cell clones (TCC) by undergoing a noncovalent association with MHC-peptide complexes on HLA-matched APCs.
HLA-matched Binding (association) of in T cell associated with lidocaine
12) Confidence 0.04 Published 1999 Journal J. Immunol. Section Abstract Doc Link 9886437 Disease Relevance 0 Pain Relevance 0.14
An additional Achilles heel of the autoimmune theory of JIA pathogenesis is the fact that HLA associations seen in one ethnic group are not found in others, suggesting that HLA is an associative, not mechanistic, linkage to JIA[15].
HLA Binding (associations) of associated with arthritis
13) Confidence 0.04 Published 2007 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC1904449 Disease Relevance 0.77 Pain Relevance 0.32
The presence of T cells within the inflamed synovium, the frequency of antinuclear antibodies, and the association of specific subtypes with specific HLA alleles [6] have all been powerful arguments that the illnesses collectively referred to as JIA represent an "autoimmune" disease whose pathogenesis is rooted in the dysregulation of mechanisms through which T cells distinguish "self" from "non-self" [7].
HLA Binding (association) of in T cells associated with disease and arthritis
14) Confidence 0.04 Published 2007 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC1904449 Disease Relevance 0.45 Pain Relevance 0.15
The most prominent genetic association in RA is confined to the human leukocyte antigen (HLA) locus.
HLA Binding (association) of in leukocyte associated with rheumatoid arthritis
15) Confidence 0.04 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1976626 Disease Relevance 0.83 Pain Relevance 0.24
JIA can be subdivided into seven clinically more homogeneous subtypes, using the International League of Associations for Rheumatology (ILAR) classification system.8 As in other autoimmune diseases there are well-established associations of the HLA region with JIA.9
HLA Binding (associations) of associated with autoimmune disease and arthritis
16) Confidence 0.03 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2935325 Disease Relevance 2.02 Pain Relevance 0.56
HLA-B*27 and HLA-B*57), natural killer cell activity regulated by killer Ig like receptor/HLA interaction, the presence of autoantibodies and/or alloantibodies and more efficient immunological effects after toll like receptor stimulation.
HLA Binding (interaction) of in natural killer cell
17) Confidence 0.03 Published 2010 Journal Proteome Sci Section Body Doc Link PMC3016264 Disease Relevance 0.81 Pain Relevance 0.09
Previous studies have shown that HLA factors might be associated with the development of TGCT.
HLA Spec (might) Binding (associated) of associated with testicular cancer
18) Confidence 0.02 Published 2008 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2735737 Disease Relevance 0.67 Pain Relevance 0
The first HLA genotyping study by Ă–zdemir and colleagues [75] in 55 Japanese patients showed two associations: one HLA susceptibility allele and one HLA protective allele (relative risk 3.26 and 0.26 respectively).
HLA Binding (associations) of
19) Confidence 0.02 Published 2008 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2735737 Disease Relevance 0.61 Pain Relevance 0
Autoantibodies and autoantigens in autoimmune hepatitis: important tools in clinical practice and to study pathogenesis of the disease

Autoimmune hepatitis (AIH) is a chronic necroinflammatory disease of the liver characterized by hypergammaglobulinemia, characteristic autoantibodies, association with HLA DR3 or DR4 and a favorable response to immunosuppressive treatment.

HLA Binding (association) of in liver associated with hypergammaglobulinemia, autoimmune hepatitis and disease
20) Confidence 0.01 Published 2004 Journal J Autoimmune Dis Section Title Doc Link PMC544946 Disease Relevance 1.54 Pain Relevance 0

General Comments

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