INT79489

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Context Info
Confidence 0.61
First Reported 1999
Last Reported 2003
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 2.38
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adra2a) plasma membrane (Adra2a) cytoplasm (Adra2a)
signal transducer activity (Adra2a)
Anatomy Link Frequency
optic nerve 1
Adra2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 2 100.00 Very High Very High Very High
Eae 4 99.88 Very High Very High Very High
Clonidine 2 98.80 Very High Very High Very High
Neuropathic pain 3 98.40 Very High Very High Very High
beta blocker 1 82.72 Quite High
Pain 2 81.68 Quite High
monoamine 1 80.44 Quite High
Hyperalgesia 1 76.24 Quite High
allodynia 1 75.56 Quite High
Spontaneous pain 1 75.12 Quite High
Disease Link Frequency Relevance Heat
Injury 4 99.88 Very High Very High Very High
Neuropathic Pain 5 98.40 Very High Very High Very High
Diabetes Mellitus 9 98.24 Very High Very High Very High
Ocular Hypertension 3 95.56 Very High Very High Very High
Glaucoma 1 91.28 High High
Neurodegenerative Disease 1 90.32 High High
Congenital Anomalies 2 83.16 Quite High
Nociception 1 82.96 Quite High
Pain 3 81.68 Quite High
Hyperalgesia 1 76.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compared to unoperated rats, CCI rats had bilaterally lower RG-20 mRNA, corresponding to the alpha2A-adrenergic receptor subtype (affected 62.4 +/- 22.1% and contralateral 69.5 +/- 16.6% of unoperated, P<0.05), and RG-10 mRNA, corresponding to the alpha2C-adrenergic receptor subtype (affected 49.2 +/- 19.1% and contralateral 50.0 +/- 14.4% of unoperated, P<0.05).
Transcription (had) of RG-10 mRNA associated with eae
1) Confidence 0.61 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12946573 Disease Relevance 0.54 Pain Relevance 0.44
In the present study, the neuroprotective activity of the alpha2-adrenoreceptor agonists brimonidine, AGN 191103, and clonidine were examined in an animal model that simulates secondary neuronal degeneration of the optic nerve in a way thought to be independent of elevation of intraocular pressure.
Spec (examined) Transcription (activity) of alpha2-adrenoreceptor in optic nerve associated with agonist, ocular hypertension and clonidine
2) Confidence 0.53 Published 1999 Journal Invest. Ophthalmol. Vis. Sci. Section Abstract Doc Link 9888428 Disease Relevance 0.52 Pain Relevance 0.23
The density of [3H] p-aminoclonidine binding sites and the level of expression of mRNA encoding for alpha2A-adrenoceptor subtype were also reduced as a function of diabetes.
Transcription (expression) of alpha2A-adrenoceptor associated with diabetes mellitus
3) Confidence 0.22 Published 1999 Journal Brain Res. Section Abstract Doc Link 10350553 Disease Relevance 1.31 Pain Relevance 0.55

General Comments

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