INT79491

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Context Info
Confidence 0.17
First Reported 1998
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 8
Disease Relevance 1.67
Pain Relevance 5.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
shell 2
caudate-putamen 1
striatum 1
jaw 1
cortex 1
Inadl2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 26 100.00 Very High Very High Very High
Substantia nigra 4 100.00 Very High Very High Very High
Desipramine 12 99.78 Very High Very High Very High
Nucleus accumbens 31 99.68 Very High Very High Very High
fluoxetine 15 99.46 Very High Very High Very High
Morphine 8 95.56 Very High Very High Very High
opiate 4 94.64 High High
addiction 8 94.36 High High
antidepressant 12 91.48 High High
dopamine receptor 3 79.84 Quite High
Disease Link Frequency Relevance Heat
Sprains And Strains 24 98.36 Very High Very High Very High
Opiate Addiction 4 94.64 High High
Drug Dependence 4 87.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These differences in basal D1-like and D2-like receptor binding, and their differential modulation after self-administration and during extinction, may be reflected in the greater vulnerability to opiate addiction shown by LEW strain.
D2-like Binding (binding) of associated with addiction, opiate and sprains and strains
1) Confidence 0.17 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 19376142 Disease Relevance 0.54 Pain Relevance 0.35
During the early phases of extinction only F344 rats showed alterations in D2-like receptor binding, however in the latter phases a specific modulation occurred in both strains.
D2-like Binding (binding) of associated with sprains and strains
2) Confidence 0.17 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 19376142 Disease Relevance 0.47 Pain Relevance 0.36
Conversely, the LEW rats exhibited stronger D2-like binding in the caudate-putamen.
D2-like Binding (binding) of in caudate-putamen
3) Confidence 0.15 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 19376142 Disease Relevance 0.36 Pain Relevance 0.29
Under basal conditions, binding to D1-like receptors in the olfactory tubercle and substantia nigra, and to D2-like receptors in the Pyriform cortex and hippocampal-CA1 was lower in LEW rats than in F344 rats.
D2-like Binding (binding) of in cortex associated with substantia nigra
4) Confidence 0.13 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 19376142 Disease Relevance 0.30 Pain Relevance 0.30
Tranylcypromine, however, had no effect on D2-like binding in the nucleus accumbens but decreased binding in the striatum.
D2-like Binding (binding) of in striatum associated with nucleus accumbens
5) Confidence 0.10 Published 1998 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 9888623 Disease Relevance 0 Pain Relevance 1.33
Measurement of D2-like binding by receptor autoradiography, using the ligand [3H]YM-09151-2, revealed that both fluoxetine and desipramine increased D2-like binding in the nucleus accumbens shell; fluoxetine had a similar effect in the nucleus accumbens core.
D2-like Binding (binding) of in shell associated with nucleus accumbens, desipramine and fluoxetine
6) Confidence 0.10 Published 1998 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 9888623 Disease Relevance 0 Pain Relevance 1.12
Measurement of D2-like binding by receptor autoradiography, using the ligand [3H]YM-09151-2, revealed that both fluoxetine and desipramine increased D2-like binding in the nucleus accumbens shell; fluoxetine had a similar effect in the nucleus accumbens core.
D2-like Binding (binding) of in shell associated with nucleus accumbens, desipramine and fluoxetine
7) Confidence 0.10 Published 1998 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 9888623 Disease Relevance 0 Pain Relevance 1.25
These results implicate a novel, dopamine D1-like receptor that is coupled to a transduction system other than/additional to adenylyl cyclase, and suggest that its functional role extends to the regulation of jaw movements by synergistic interactions with dopamine D2-like receptors.
D2-like Binding (interactions) of in jaw associated with dopamine
8) Confidence 0.06 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10078986 Disease Relevance 0 Pain Relevance 0.38

General Comments

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