INT79494

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Context Info
Confidence 0.70
First Reported 1999
Last Reported 2011
Negated 9
Speculated 16
Reported most in Body
Documents 577
Total Number 593
Disease Relevance 442.94
Pain Relevance 69.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (VEGFA) growth (VEGFA) extracellular region (VEGFA)
proteinaceous extracellular matrix (VEGFA) cytoplasm (VEGFA)
Anatomy Link Frequency
fibroblasts 31
endothelial cells 31
plasma 30
retina 24
epithelial cells 18
VEGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 1972 100.00 Very High Very High Very High
metalloproteinase 1029 100.00 Very High Very High Very High
imagery 965 100.00 Very High Very High Very High
COX2 133 100.00 Very High Very High Very High
agonist 958 99.98 Very High Very High Very High
ischemia 611 99.98 Very High Very High Very High
rheumatoid arthritis 1065 99.84 Very High Very High Very High
Inflammation 3699 99.80 Very High Very High Very High
anesthesia 273 99.78 Very High Very High Very High
Morphine 70 99.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 13385 100.00 Very High Very High Very High
Diabetes Mellitus 3711 100.00 Very High Very High Very High
Hypoxia 2449 100.00 Very High Very High Very High
Breast Cancer 1812 100.00 Very High Very High Very High
Lymphedema 853 100.00 Very High Very High Very High
Adhesions 619 100.00 Very High Very High Very High
Necrosis 367 100.00 Very High Very High Very High
Atherosclerosis 364 100.00 Very High Very High Very High
Adult Respiratory Distress Syndrome 278 100.00 Very High Very High Very High
Skin Cancer 275 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sex steroids have been shown to increase VEGF expression in normal breast tissue as well as in experimental breast cancer, both in vitro and in vivo [6-10], and an estrogen responsive element (ERE) has been identified in the promoter region of the gene for VEGF [11].
Positive_regulation (increase) of Gene_expression (expression) of VEGF associated with breast cancer
1) Confidence 0.70 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2279135 Disease Relevance 0.89 Pain Relevance 0
In the present study, we examined the effect of capsaicin on constitutive and induced vascular endothelial cell growth factor (VEGF) expression in malignant melanoma cells.
Positive_regulation (induced) of Gene_expression (expression) of VEGF in endothelial cell associated with qutenza and skin cancer
2) Confidence 0.70 Published 2002 Journal J. Cancer Res. Clin. Oncol. Section Abstract Doc Link 12242509 Disease Relevance 0.35 Pain Relevance 0.27
CONCLUSIONS: These data suggest that inhibition of cellular proliferation by capsaicin follows enhanced VEGF production by remaining melanoma cells by enhancing HIF-1alpha expression and binding to HRE.


Positive_regulation (enhanced) of Gene_expression (production) of VEGF
3) Confidence 0.70 Published 2002 Journal J. Cancer Res. Clin. Oncol. Section Body Doc Link 12242509 Disease Relevance 0.07 Pain Relevance 0
Other investigators reported that patients with renal failure had significantly elevated plasma levels and overexpression of VEGF in renal tissue compared with SLE patients with normal renal function [22].
Positive_regulation (overexpression) of Gene_expression (overexpression) of VEGF in plasma associated with renal failure and systemic lupus erythematosus
4) Confidence 0.69 Published 2007 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2765643 Disease Relevance 1.22 Pain Relevance 0.03
Morphine sulfate inhibits hypoxia-induced vascular endothelial growth factor expression in endothelial cells and cardiac myocytes.
Positive_regulation (induced) of Gene_expression (expression) of vascular endothelial growth factor in endothelial cells associated with hypoxia and morphine
5) Confidence 0.69 Published 2001 Journal J. Mol. Cell. Cardiol. Section Title Doc Link 11735263 Disease Relevance 0.71 Pain Relevance 0.53
Our results show that the inhibitory effects of morphine on hypoxia-induced VEGF expression in endothelial cells and cardiac myocytes can lead to a decrease in the autocrine and paracrine stimulation and hence limit neovascularization of the ischemic myocardium.
Positive_regulation (-) of Gene_expression (expression) of VEGF in myocardium associated with hypoxia and morphine
6) Confidence 0.69 Published 2001 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 11735263 Disease Relevance 0.55 Pain Relevance 0.96
Enzyme-linked immunosorbent assays showed that morphine sulfate significantly inhibited hypoxia-induced VEGF expression in mouse heart microvascular endothelial cells (SMHEC4), primary cultures of human umbilical vein endothelial cells (HUVECs) and in primary cultures of rat cardiac myocytes (P<0.05).
Positive_regulation (-) of Gene_expression (expression) of VEGF in endothelial cells associated with hypoxia and morphine
7) Confidence 0.69 Published 2001 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 11735263 Disease Relevance 0.75 Pain Relevance 0.64
Given the failure of previous conventional therapy we are tempted to state that overexpression of VEGF at the level of the thigh and calf muscles prevented the amputation, which would have been the only alternative left for the three patients.
Positive_regulation (overexpression) of Gene_expression (overexpression) of VEGF in muscles associated with amputation
8) Confidence 0.69 Published 2007 Journal Genomic Med Section Body Doc Link PMC2276892 Disease Relevance 0.46 Pain Relevance 0
A late cryo-induced angiogenesis was observed 8-15 days after treatment (expression of VEGF increased from 13% in untreated tumours to 77 and 70%, respectively).
Positive_regulation (increased) of Gene_expression (expression) of VEGF associated with cancer
9) Confidence 0.69 Published 2006 Journal Lung Cancer Section Abstract Doc Link 16889870 Disease Relevance 0.93 Pain Relevance 0.29
CONCLUSION: These results suggest that the expression of VEGF is upregulated and involved in the development of inflammatory changes in synovial tissues in TMJs with ID.


Positive_regulation (upregulated) of Gene_expression (expression) of VEGF
10) Confidence 0.69 Published 2002 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 11925532 Disease Relevance 0.06 Pain Relevance 0
The gene expressions of TGF-beta1 and VEGF were significantly increased at the concentration of 0.1 mg/mL HA and 0.1 mg/mL Hylan, respectively (alpha < 0.05).
Positive_regulation (increased) of Gene_expression (expressions) of VEGF
11) Confidence 0.69 Published 2010 Journal J. Orthop. Res. Section Abstract Doc Link 19890996 Disease Relevance 0.56 Pain Relevance 0.30
Overexpression of VEGF has been shown in high stage bladder tumor.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of VEGF in bladder associated with bladder cancer
12) Confidence 0.68 Published 2010 Journal Urology Annals Section Body Doc Link PMC2955232 Disease Relevance 1.48 Pain Relevance 0
We describe the anesthetic management of 30 patients with class 3 or 4 angina, enrolled in a Phase 1 clinical trial to assess the safety and bioactivity of direct myocardial gene transfer of naked DNA-encoding vascular endothelial growth factor (phVEGF(165)), as sole therapy for refractory angina.
Positive_regulation (transfer) of Gene_expression (transfer) of VEGF associated with angina
13) Confidence 0.67 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11133594 Disease Relevance 0.42 Pain Relevance 0.55
Increased vascular-endothelial growth factor (VEGF) tumor expression and response to epidermal growth factor receptor (EGF-R) inhibitor erlotinib in non-small cell lung cancer (NSCLC).
Positive_regulation (Increased) of Gene_expression (expression) of VEGF in lung associated with lung cancer, non-small-cell lung cancer and cancer
14) Confidence 0.67 Published 2008 Journal J Thorac Oncol Section Title Doc Link 18317076 Disease Relevance 0.55 Pain Relevance 0.09
In a recent study, we found a significantly increased MVD and VEGF expression in MPN compared to controls especially in cases with high JAK2-V617F mutant allele burdens [17].
Positive_regulation (increased) of Gene_expression (expression) of VEGF associated with myeloproliferative disorder
15) Confidence 0.67 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2902424 Disease Relevance 1.70 Pain Relevance 0.04
Despite the increased levels of VEGF in the BAL, a decreased expression of VEGF in the lung tissue, as revealed by the IHC staining, was observed specifically in the IIR group.
Positive_regulation (increased) of Gene_expression (levels) of VEGF in lung
16) Confidence 0.67 Published 2006 Journal Crit Care Section Body Doc Link PMC1751039 Disease Relevance 0.67 Pain Relevance 0.04
Systemic overexpression of VEGF has been shown to cause widespread capillary leakage in multiple organs [9], and high plasma levels of VEGF were found in ARDS patients [16].
Positive_regulation (overexpression) of Gene_expression (overexpression) of VEGF in plasma associated with adult respiratory distress syndrome
17) Confidence 0.67 Published 2006 Journal Crit Care Section Body Doc Link PMC1751039 Disease Relevance 1.14 Pain Relevance 0
Contrary to current dogma, treatment paradigms directed at increasing VEGF production in the diabetic patient with critical limb ischemia might not be beneficial.
Positive_regulation (increasing) of Gene_expression (production) of VEGF in limb associated with diabetes mellitus and ischemia
18) Confidence 0.67 Published 2001 Journal Ann Vasc Surg Section Abstract Doc Link 11414092 Disease Relevance 1.74 Pain Relevance 0.40
Elevated VEGF production in the serum has also been detected in diabetic retinopathy [30], hyperlipidaimia [31] and hypertention [32] asymptomatic for atherosclerosis.
Positive_regulation (Elevated) of Gene_expression (production) of VEGF associated with atherosclerosis and diabetic retinopathy
19) Confidence 0.67 Published 2003 Journal J Transl Med Section Body Doc Link PMC239962 Disease Relevance 1.43 Pain Relevance 0.28
We propose that the migratory defect could be caused by the increased autocrine VEGF production of the peripheral monocytes.
Positive_regulation (increased) of Gene_expression (production) of VEGF in monocytes
20) Confidence 0.67 Published 2003 Journal J Transl Med Section Body Doc Link PMC239962 Disease Relevance 0.70 Pain Relevance 0.04

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