INT79502

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Context Info
Confidence 0.78
First Reported 1999
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 26
Total Number 27
Disease Relevance 2.83
Pain Relevance 7.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Pvalb)
Anatomy Link Frequency
interneurons 5
muscle 3
brain 3
hippocampus 2
neurons 2
Pvalb (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 7 100.00 Very High Very High Very High
GABAergic 82 99.96 Very High Very High Very High
Somatostatin 33 99.94 Very High Very High Very High
Hippocampus 39 99.84 Very High Very High Very High
Morphine 12 99.78 Very High Very High Very High
cOX1 2 99.60 Very High Very High Very High
projection neuron 5 98.42 Very High Very High Very High
interneuron 70 97.96 Very High Very High Very High
Eae 3 97.84 Very High Very High Very High
nociceptor 136 95.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 57 100.00 Very High Very High Very High
Aging 69 98.20 Very High Very High Very High
Cognitive Disorder 111 97.96 Very High Very High Very High
Targeted Disruption 154 95.20 Very High Very High Very High
Urological Neuroanatomy 6 79.20 Quite High
Cytomegalovirus Infection 6 75.40 Quite High
Generalized Anxiety Disorder 4 69.28 Quite High
Umbilical Hernia 24 67.12 Quite High
Inguinal Hernia 1 62.60 Quite High
Anxiety Disorder 3 59.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mechanism of morphine action on parvalbumin expression in neonatal mouse brain is not evident, but alterations in the expression patterns of parvalbumin in specific regions of the developing brain might be one of the cellular mechanisms by which addictive drugs modify the functional aspects of the developing CNS.
Gene_expression (expression) of parvalbumin in brain associated with morphine
1) Confidence 0.78 Published 2000 Journal Synapse Section Abstract Doc Link 10657036 Disease Relevance 0.09 Pain Relevance 0.44
The mechanism of morphine action on parvalbumin expression in neonatal mouse brain is not evident, but alterations in the expression patterns of parvalbumin in specific regions of the developing brain might be one of the cellular mechanisms by which addictive drugs modify the functional aspects of the developing CNS.
Gene_expression (expression) of parvalbumin in brain associated with morphine
2) Confidence 0.78 Published 2000 Journal Synapse Section Abstract Doc Link 10657036 Disease Relevance 0.10 Pain Relevance 0.46
We then tested these “conditional AAVs” (AAV-LS1L-GFP; AAV-LS2L-RFP) using two different Cre knockin drivers, the Pv-cre mouse, which expresses Cre in parvalbumin-containing (PV+) GABAergic neurons [23], and the Emx-cre mouse, which expresses Cre in glutamatergic neurons in the forebrain [24].
Gene_expression (expresses) of parvalbumin in GABAergic neurons associated with gabaergic
3) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2289876 Disease Relevance 0.14 Pain Relevance 0.23
GABAergic interneurons expressing parvalbumin had elongated nuclei with a diameter of 9 to 11 µm, in which areas of intense TO-PRO-3 labeling formed 1 or 2 clumps in the vicinity of what was likely to be the nucleolus (Fig. 3B).
Gene_expression (expressing) of parvalbumin in interneurons associated with gabaergic
4) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651623 Disease Relevance 0 Pain Relevance 0.16
Variation in ovarian steroid levels altered the subcellular distribution of MORs in PARV-labeled dendrites but not terminals.
Gene_expression (distribution) of PARV in dendrites associated with mu opioid receptor
5) Confidence 0.38 Published 2009 Journal Exp. Neurol. Section Abstract Doc Link 19505458 Disease Relevance 0 Pain Relevance 0.53
Development of proprioceptors, marked by the expression of Parvalbumin (PV), and low-threshold mechanoceptors, marked by the expression of TrkB (the receptor for the brain-derived neurotrophic factor or BDNF), was unaffected (See Additional file 8).
Gene_expression (expression) of Parvalbumin in brain
6) Confidence 0.35 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0.13 Pain Relevance 0.48
The remaining 5% of neurons are composed of aspiny interneurons, which have been classified on the basis of their morphology, protein content and electrophysiological properties as large cholinergic interneurons and somatostatin-, parvalbumin- and calretinin-expressing GABAergic interneurons [4].
Gene_expression (expressing) of parvalbumin in interneurons associated with gabaergic and somatostatin
7) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651623 Disease Relevance 0.15 Pain Relevance 0.55
1000, gift from Paul Greengard) were used, as well as rabbit polyclonal antibodies against parvalbumin (1?
Gene_expression (antibodies) of parvalbumin
8) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651623 Disease Relevance 0 Pain Relevance 0.11
We found a substantial and highly significant loss of PV-interneurons in aged hippocampus (Fig. 4), with the CA2-3 region being the most affected (20% decrease for CA1, main effect of age: F(1,17)?
Gene_expression (significant) of PV-interneurons in hippocampus associated with hippocampus
9) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.31 Pain Relevance 0.25
Therefore, to explore the relationship between preservation of PV-interneurons and hippocampal forms of memory in C3-treated mice, we analyzed data from the probe component of the Morris water maze for the specific mice used for the PV-interneuron counts.
Gene_expression (preservation) of PV-interneurons in interneuron associated with interneuron
10) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.06 Pain Relevance 0.14
Rescue of PV-interneurons in hippocampus was observed not only in IL-6 deficient mice, but in mice treated long-term treatment with an SOD mimetic (C3).
Gene_expression (Rescue) of PV-interneurons in hippocampus associated with hippocampus
11) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.07 Pain Relevance 0.13
To begin to examine the identity of the Runx1-expressing neurons in the dorsolateral rostral hindbrain, we compared the expression of ß-gal to that of the calcium-binding protein, parvalbumin (PV), on sections from P10 Runx1lacZ/+ mice.
Gene_expression (expression) of parvalbumin in hindbrain
12) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978708 Disease Relevance 0.09 Pain Relevance 0.07
Intriguingly, this molecule is very specifically excluded from the TrkC-expressing population that includes the parvalbumin expressing proprioceptors [23] and certain low-threshold mechanoreceptors [24].
Gene_expression (expressing) of parvalbumin in mechanoreceptors
13) Confidence 0.27 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0.06 Pain Relevance 0.03
GABAergic neurons are classified into several subtypes according to the expression of chemical markers, such as parvalbumin and somatostatin [44,45].
Gene_expression (expression) of parvalbumin in GABAergic neurons associated with gabaergic and somatostatin
14) Confidence 0.26 Published 2010 Journal Mol Brain Section Body Doc Link PMC3023674 Disease Relevance 0.69 Pain Relevance 0.31
In addition, we found that 25% of the EGFP+ cells co-expressed parvalbumin (Figure 1B), consistent with findings in another mouse line [15].
Gene_expression (expressed) of parvalbumin
15) Confidence 0.23 Published 2009 Journal Mol Pain Section Body Doc Link PMC2689203 Disease Relevance 0.35 Pain Relevance 0.41
To establish whether some of the earliest labeled interneurons made direct monosynaptic contacts with motoneurons we investigated the expression of the calcium binding proteins calbindin and parvalbumin which are known to label Renshaw cells and Ia inhibitory neurons [29].
Spec (investigated) Gene_expression (expression) of parvalbumin in motoneurons
16) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909228 Disease Relevance 0 Pain Relevance 0.08
The central projections of muscle proprioceptors were identified by their expression of calcium binding protein parvalbumin (PV) immunoreactivity using a mouse monoclonal antibody (1?
Gene_expression (expression) of parvalbumin in muscle
17) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909228 Disease Relevance 0 Pain Relevance 0.14
Furthermore, interneurons that co-express various calcium binding proteins such calbindin-D28k and parvalbumin [29] and parvalbumin and calretinin [48] were also found in this region known to be populated with last order premotor interneurons [49].
Gene_expression (express) of parvalbumin in interneurons
18) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909228 Disease Relevance 0 Pain Relevance 0.03
We characterized the time course and stability of GFP expression after AAV transfection in Pv-cre mice.
Gene_expression (transfection) of Pv-cre
19) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2289876 Disease Relevance 0 Pain Relevance 0.14
Double tissue immunoprocessing revealed that some of the virally labeled interneurons in lamina VII also co-expressed the calcium binding protein parvalbumin (PV; Fig. 6D and E).
Gene_expression (so co-expres) of parvalbumin in lamina
20) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909228 Disease Relevance 0 Pain Relevance 0.12

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