INT79505

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Context Info
Confidence 0.36
First Reported 1999
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 1.43
Pain Relevance 4.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin2b) embryo development (Grin2b)
Anatomy Link Frequency
brain 2
spinal 1
blood vessels 1
neurons 1
interneurons 1
Grin2b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
projection neuron 2 99.40 Very High Very High Very High
spinal dorsal horn 14 99.32 Very High Very High Very High
Morphine 11 99.22 Very High Very High Very High
nMDA receptor 83 99.20 Very High Very High Very High
Hyperalgesia 70 99.04 Very High Very High Very High
Ultiva 55 98.08 Very High Very High Very High
central sensitization 21 96.92 Very High Very High Very High
Somatostatin 4 96.88 Very High Very High Very High
Inflammation 34 95.60 Very High Very High Very High
ketamine 37 95.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 105 99.04 Very High Very High Very High
INFLAMMATION 31 95.60 Very High Very High Very High
Cognitive Disorder 3 92.20 High High
Pain 54 84.28 Quite High
Cancer Pain 1 64.40 Quite High
Nociception 46 64.08 Quite High
Neuropathic Pain 66 63.76 Quite High
Myalgia 17 50.00 Quite Low
Ganglion Cysts 24 5.00 Very Low Very Low Very Low
Injury 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Coimmunoprecipitation indicates that Shank, a postsynaptic density protein associated with mGluRs, formed a complex involving PSD-95 (postsynaptic density-95), NR2B, and Src in the spinal dorsal horn.
NR2B Binding (complex) of in spinal associated with spinal dorsal horn
1) Confidence 0.36 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15483135 Disease Relevance 0.59 Pain Relevance 1.20
However, there have been no reports on whether tyrosine phosphorylation of NR2B is associated with the postoperative hyperalgesia induced by remifentanil.
NR2B Binding (associated) of associated with hyperalgesia and ultiva
2) Confidence 0.36 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.41 Pain Relevance 1.25
Immunofluorescence with an antibody that recognized NR1 and another that recognized NR2A and NR2B showed that NR1 and NR2B colocalized in 90% of DRG neurons, including most A-fibers (identified by the presence of neurofilament 200 kDa).
NR2B Binding (recognized) of in neurons
3) Confidence 0.34 Published 2002 Journal J. Comp. Neurol. Section Abstract Doc Link 11954032 Disease Relevance 0.08 Pain Relevance 0.25
Inhibition of [(3)H]ifenprodil binding in the presence of trifluoroperazine by 10 NR1a/NR2B selective agents was highly correlated with their inhibition at rat NR1a/NR2B receptors expressed in Xenopus ooctyes and [(3)H]TCP binding to rat brain NR2B subunit containing NMDA receptors but not with their inhibition of [(3)H]DTG binding.
NR2B Neg (inhibition) Binding (inhibition) of in brain associated with nmda receptor
4) Confidence 0.32 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11123375 Disease Relevance 0 Pain Relevance 0.21
Inhibition of [(3)H]ifenprodil binding in the presence of trifluoroperazine by 10 NR1a/NR2B selective agents was highly correlated with their inhibition at rat NR1a/NR2B receptors expressed in Xenopus ooctyes and [(3)H]TCP binding to rat brain NR2B subunit containing NMDA receptors but not with their inhibition of [(3)H]DTG binding.
NR2B Binding (binding) of in brain associated with nmda receptor
5) Confidence 0.31 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11123375 Disease Relevance 0 Pain Relevance 0.24
We did not reprobe for amounts of total Src/Fyn/Yes as total levels of those proteins bound to NR2B are directly affected by phosphorylation, i.e. phosphorylation promotes the association of the proteins to NR2B (Yu et al., 1997); the ratio of phospho-Src/total Src could thus potentially remain constant despite a significant increase in the total amount of activated phospho-Src bound to NR2B.
NR2B Binding (association) of
6) Confidence 0.30 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.12 Pain Relevance 0.19
We did not reprobe for amounts of total Src/Fyn/Yes as total levels of those proteins bound to NR2B are directly affected by phosphorylation, i.e. phosphorylation promotes the association of the proteins to NR2B (Yu et al., 1997); the ratio of phospho-Src/total Src could thus potentially remain constant despite a significant increase in the total amount of activated phospho-Src bound to NR2B.
NR2B Binding (bound) of
7) Confidence 0.30 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.06 Pain Relevance 0.14
Labeling for NMDAR2B was strong in projection neurons and ChAT interneurons, and only moderate in SOM, GAD67 and PARV interneurons.
NMDAR2B Binding (Labeling) of in interneurons associated with somatostatin and projection neuron
8) Confidence 0.29 Published 1999 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9889300 Disease Relevance 0 Pain Relevance 0.38
In this study, we determined whether prenatal morphine exposure altered the synaptic complex association between PSD-95 and three major NMDAR subunits (NR1, NR2A, and NR2B), at the mRNA and protein levels, within the hippocampal CA1 subregion (an important integration area for mammalian learning and memory) of rat offspring along with the performance of long-term cognitive functions.
NR2B Spec (whether) Binding (association) of associated with cognitive disorder and morphine
9) Confidence 0.23 Published 2009 Journal Neuroscience Section Abstract Doc Link 19041927 Disease Relevance 0.17 Pain Relevance 0.52
We found no NMDAR2B or GluR1 immunoreactive products within spindles, but some well labelled NMDAR2B or GluR1 fibres were seen in the masseter nerve and around blood vessels (not shown).
NMDAR2B Neg (no) Binding (found) of in blood vessels
10) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886111 Disease Relevance 0 Pain Relevance 0.24

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