INT79506

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Context Info
Confidence 0.78
First Reported 1999
Last Reported 2010
Negated 3
Speculated 4
Reported most in Body
Documents 122
Total Number 132
Disease Relevance 43.71
Pain Relevance 73.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin2b) embryo development (Grin2b)
Anatomy Link Frequency
spinal cord 15
dorsal horn 10
brain 6
neurons 5
hippocampus 4
Grin2b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 1654 100.00 Very High Very High Very High
Glutamate 480 100.00 Very High Very High Very High
Glutamate receptor 109 100.00 Very High Very High Very High
Kinase C 57 100.00 Very High Very High Very High
Spinal cord 740 99.98 Very High Very High Very High
antagonist 313 99.96 Very High Very High Very High
Neuronal nitric oxide synthase 6 99.90 Very High Very High Very High
Dynorphin 1 99.88 Very High Very High Very High
long-term potentiation 1265 99.84 Very High Very High Very High
Dorsal horn 262 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 28 99.92 Very High Very High Very High
Status Epilepticus 57 99.82 Very High Very High Very High
INFLAMMATION 475 99.76 Very High Very High Very High
Pain 504 99.72 Very High Very High Very High
Neuropathic Pain 405 99.64 Very High Very High Very High
Hyperalgesia 749 99.62 Very High Very High Very High
Teratocarcinoma 1 99.56 Very High Very High Very High
Targeted Disruption 33 99.54 Very High Very High Very High
Brain Hemorrhage 306 99.40 Very High Very High Very High
Depression 878 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ifenprodil induced antinociception and decreased the expression of NR2B subunits in the dorsal horn after chronic dorsal root ganglia compression in rats.
Gene_expression (expression) of NR2B in dorsal horn associated with antinociception, analgesic and dorsal horn
1) Confidence 0.78 Published 2009 Journal Anesth. Analg. Section Title Doc Link 19224818 Disease Relevance 0.18 Pain Relevance 0.68
We found that, in addition to a marked suppression of thermal hyperalgesia and mechanical allodynia, intrathecal injection ifenprodil treatment causes a decreased expression of NR2B in the spinal cord.
Gene_expression (expression) of NR2B in spinal cord
2) Confidence 0.78 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19224818 Disease Relevance 0.07 Pain Relevance 0
RESULTS: The data revealed increased expression of NR2B subunits in the superficial dorsal horn in CCD rats.
Gene_expression (expression) of NR2B in CCD
3) Confidence 0.78 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19224818 Disease Relevance 0.08 Pain Relevance 0
No NR2B specific IgG was detected in sera from PBS or KLH group.
Neg (No) Gene_expression (detected) of NR2B
4) Confidence 0.77 Published 2007 Journal Chin. Med. J. Section Body Doc Link 17517177 Disease Relevance 0.12 Pain Relevance 0
The expression of NR2B protein in the lumbar spinal cord was determined using Western blotting.
Gene_expression (expression) of NR2B protein in spinal cord
5) Confidence 0.77 Published 2007 Journal Chin. Med. J. Section Body Doc Link 17517177 Disease Relevance 0.15 Pain Relevance 0
The expression of NR2B protein in group NR2B was significantly lower than in PBS and KLH groups on day 7 after surgery.
Gene_expression (expression) of NR2B protein
6) Confidence 0.77 Published 2007 Journal Chin. Med. J. Section Body Doc Link 17517177 Disease Relevance 0 Pain Relevance 0
To localize and assess the expression of NR2B phosphorylation at Tyr-1472 in the spinal cord during the maintenance of hyperalgesia induced by remifentanil, immunohistochemical studies were performed.
Gene_expression (expression) of NR2B in spinal cord associated with hyperalgesia, ultiva and spinal cord
7) Confidence 0.77 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.56 Pain Relevance 0.98
The expression of NR2B tyrosine phosphorylation in the superficial dorsal horn was weak in rats receiving sevoflurane and saline without surgery.
Gene_expression (expression) of NR2B in dorsal horn associated with dorsal horn
8) Confidence 0.77 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.39 Pain Relevance 1.08
This hypothesis is supported by immunohistochemical and westernblotting experiments in our study showing that remifentanil significantly increased the expression of tyrosine phosphorylation of NR2B in the lamina I-II of the L4-L5 spinal cord.
Gene_expression (expression) of NR2B in spinal cord associated with ultiva and spinal cord
9) Confidence 0.77 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.77 Pain Relevance 1.65
Intraoperative infusion of remifentanil significantly enhanced the expression of NR2B tyrosine phosphorylation in the superficial dorsal horn of spinal cord(P < 0.05).
Gene_expression (expression) of NR2B in spinal cord associated with dorsal horn, ultiva and spinal cord
10) Confidence 0.77 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.24 Pain Relevance 1.10
To quantificate the expression of NR2B phosphorylation at Tyr-1472 in the dorsal horn during the maintenance of hyperalgesia induced by remifentanil, western blot studies were performed.
Gene_expression (expression) of NR2B in dorsal horn associated with hyperalgesia, dorsal horn and ultiva
11) Confidence 0.77 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.15 Pain Relevance 0.98
The expression of NR2B tyrosine phosphorylation in rats receiving intraoperative remifentanil infusion was significantly upregulated when compared with rats receiving intraoperative saline infusion (P < 0.01).
Gene_expression (expression) of NR2B associated with ultiva
12) Confidence 0.77 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.21 Pain Relevance 1.06
Quantitative RT-PCR and Western blot analysis indicated a 28% increase in the expression of NR2B with little or no change in the other three NR2 subunits.
Gene_expression (expression) of NR2B
13) Confidence 0.75 Published 2006 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16565418 Disease Relevance 0.57 Pain Relevance 0.21
We further investigated the expression of NR1 splice variants, NR2A and NR2B protein.
Spec (investigated) Gene_expression (expression) of NR2B protein
14) Confidence 0.72 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0.65 Pain Relevance 0.22
Thus, in the sensitized neurons suppression of the NR1 phosphorylation results in reduction of thermal hyperalgesia and a decrease in NR2B expression produces an inhibition of mechanical allodynia.
Gene_expression (expression) of NR2B in neurons associated with allodynia and thermal hyperalgesia
15) Confidence 0.72 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0.65 Pain Relevance 0.90
Interestingly, our data demonstrate a strong negative correlation between the recovery period of mechanical allodynia and the level of NR2B protein expression (Figure 8, Deming linear regression, r2 = -0.93, p = 0.0363).
Gene_expression (expression) of NR2B protein associated with allodynia
16) Confidence 0.72 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0.79 Pain Relevance 0.56
However, NR2B expression was depressed by 24 hours following the carrageenan inflammation and did not recover during the 5 day period examined.
Gene_expression (expression) of NR2B associated with inflammation
17) Confidence 0.72 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0.77 Pain Relevance 0.25
Our results showed that NMDAR1 (NR1), NMDAR2A (NR2A), NMDAR2B (NR2B), AMPAR1 (GluR1) and AMPAR2 (GluR2) subunits, and group I metabotropic glutamate receptor, mGluR5, are constitutively expressed in TG.
Gene_expression (xpressed ) of NR2B associated with glutamate receptor
18) Confidence 0.72 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17560028 Disease Relevance 0.62 Pain Relevance 0.53
Our results showed that NMDAR1 (NR1), NMDAR2A (NR2A), NMDAR2B (NR2B), AMPAR1 (GluR1) and AMPAR2 (GluR2) subunits, and group I metabotropic glutamate receptor, mGluR5, are constitutively expressed in TG.
Gene_expression (xpressed ) of NMDAR2B associated with glutamate receptor
19) Confidence 0.72 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17560028 Disease Relevance 0.62 Pain Relevance 0.53
Effects of intrathecal injection of prednisolone acetate on expression of NR2B subunit and nNOS in spinal cord of rats after chronic compression of dorsal root ganglia.
Gene_expression (expression) of NR2B in spinal cord associated with spinal cord and intrathecal
20) Confidence 0.71 Published 2007 Journal Ann. Clin. Lab. Sci. Section Title Doc Link 18000292 Disease Relevance 0.31 Pain Relevance 0.70

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