INT7952

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Context Info
Confidence 0.81
First Reported 1986
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 32
Total Number 33
Disease Relevance 1.28
Pain Relevance 15.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc3a1) plasma membrane (Slc3a1) carbohydrate metabolic process (Slc3a1)
Anatomy Link Frequency
neuron 3
striatum 2
nucleus accumbens 2
bile 2
ovaries 2
Slc3a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 712 100.00 Very High Very High Very High
agonist 124 100.00 Very High Very High Very High
Enkephalin 52 100.00 Very High Very High Very High
Nucleus accumbens 35 100.00 Very High Very High Very High
gABA 67 99.96 Very High Very High Very High
dopamine receptor 64 99.96 Very High Very High Very High
Morphine 7 99.94 Very High Very High Very High
Dynorphin 4 99.84 Very High Very High Very High
Bile 2 99.64 Very High Very High Very High
Opioid 19 99.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 20 97.60 Very High Very High Very High
Camurati-engelmann Disease 2 94.88 High High
Increased Venous Pressure Under Development 90 82.48 Quite High
Peripheral Arterial Disease 23 78.88 Quite High
Depression 26 75.00 Quite High
Decapitation 4 60.24 Quite High
Attention Deficit Hyperactivity Disorder 307 50.00 Quite Low
Targeted Disruption 7 39.72 Quite Low
Ganglion Cysts 4 37.12 Quite Low
Aids-related Complex 11 31.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results confirm the existence of release modulatory D2 and alpha-2 receptors in the medial prefrontal cortex.
Localization (release) of D2 in prefrontal
1) Confidence 0.81 Published 1991 Journal Life Sci. Section Abstract Doc Link 1846930 Disease Relevance 0 Pain Relevance 0.64
The effect of the peptide is independent of the degree of activation of dopamine D2 receptors which modulate the stimulus-evoked release of [3H]dopamine.
Localization (release) of D2 associated with dopamine
2) Confidence 0.45 Published 1989 Journal Brain Res. Section Abstract Doc Link 2550107 Disease Relevance 0 Pain Relevance 0.88
Our results, together with other previous studies on the location of D2 receptors on dopamine neurons, suggest that peripheral administration of low doses of apomorphine inhibits nigral dopamine neurons by acting at D2 receptors located on the dendrites of these neurons.
Localization (location) of D2 in dopamine neurons associated with dopamine
3) Confidence 0.43 Published 1992 Journal Neuroscience Section Abstract Doc Link 1359456 Disease Relevance 0 Pain Relevance 0.61
ACTH-(1-24) enhances the electrically stimulated release of [3H]dopamine from rat septal slices via a dopamine D2 receptor-independent mechanism.
Localization (release) of D2 associated with dopamine
4) Confidence 0.42 Published 1989 Journal Brain Res. Section Title Doc Link 2550107 Disease Relevance 0 Pain Relevance 0.68
In contrast, on the basis of several in vivo and in vitro studies, other authors have suggested the existence of an extensive colocalization of D1 and D2 in the same striatal neurons.
Localization (colocalization) of D2 in neurons
5) Confidence 0.42 Published 1995 Journal J. Comp. Neurol. Section Abstract Doc Link 7636023 Disease Relevance 0 Pain Relevance 0.41
Our study was undertaken in order to analyze in detail the expression of the D1 and D2 receptor genes in the efferent striatal populations, with special reference to the various striatal areas, and to yield insights into the question about D1 and D2 mRNA localization in the striatum.
Localization (localization) of D2 in striatum
6) Confidence 0.42 Published 1995 Journal J. Comp. Neurol. Section Abstract Doc Link 7636023 Disease Relevance 0 Pain Relevance 0.42
D1 and D2 dopamine receptor gene expression in the rat striatum: sensitive cRNA probes demonstrate prominent segregation of D1 and D2 mRNAs in distinct neuronal populations of the dorsal and ventral striatum.
Localization (segregation) of D2 in neuronal associated with dopamine receptor
7) Confidence 0.39 Published 1995 Journal J. Comp. Neurol. Section Title Doc Link 7636023 Disease Relevance 0 Pain Relevance 0.30
Similar broad peaks at 50–180 Hz were observed for D1, D2, and D3 whiskers moving across a variety of surfaces (see below).
Localization (observed) of D2 in whiskers
8) Confidence 0.36 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2525689 Disease Relevance 0.06 Pain Relevance 0
The data suggest that CB1 receptors are co-localized with D1 or D2 receptors on the same population of striatal membranes and can interact at the level of G-protein/adenylyl cyclase signal transduction.
Localization (co-localized) of D2
9) Confidence 0.33 Published 2001 Journal Neuropharmacology Section Abstract Doc Link 11378162 Disease Relevance 0 Pain Relevance 0.38
The presence of AC5 and PDE7B mRNAs in D1- and D2-containing cells suggests the participation of these enzymes in striatal functions involving dopaminergic pathways.
Localization (presence) of D2
10) Confidence 0.33 Published 2010 Journal Brain Res. Section Abstract Doc Link 19913519 Disease Relevance 0 Pain Relevance 0.34
This study was done to provide pharmacologic evidence for the location of those striatal dopamine D-1 and D-2 receptors that participate in the regulation of local acetylcholine (ACh) release.
Localization (location) of D-2 associated with dopamine
11) Confidence 0.24 Published 1986 Journal Life Sci. Section Abstract Doc Link 2940432 Disease Relevance 0 Pain Relevance 0.38
Colocalization of proenkephalin and prodynorphin mRNAs with each other as well as with D1, D2, and D3 dopamine receptor mRNAs was analyzed in the nucleus accumbens of the rat.
Spec (analyzed) Localization (Colocalization) of D2 in nucleus accumbens associated with nucleus accumbens and dopamine receptor
12) Confidence 0.24 Published 1995 Journal J. Comp. Neurol. Section Abstract Doc Link 8550882 Disease Relevance 0 Pain Relevance 0.29
The present study investigates the contribution of glial cells in the releasing effects of [d-Pen2, d-Pen5]-enkephalin (DPDPE) by using the gliotoxin l-alpha-aminoadipate (l-alpha AA).
Localization (releasing) of d-Pen2 in glial cells associated with enkephalin
13) Confidence 0.22 Published 2007 Journal Neuroscience Section Abstract Doc Link 17942234 Disease Relevance 0 Pain Relevance 0.66
Subsequent patch clamp recordings of GP neurons in rat brain slice demonstrated that activation of presynaptic D2LRs decreases GABA-A receptor-mediated currents in the pallidum (Cooper and Stanford, 2001).
Localization (decreases) of D2LRs in pallidum associated with gaba
14) Confidence 0.21 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0 Pain Relevance 0.44
Our results, and those of others, suggest that stimulating on D2 the sensory receptors located on the left side of the peritoneum triggers an E2 secretion inhibitory mechanism, that the sensory pathway arising from the right side has a stimulatory effect, and that both are mediated by the cholinergic muscarinic system.
Localization (secretion) of D2 in peritoneum
15) Confidence 0.20 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1564398 Disease Relevance 0 Pain Relevance 0.12
A bilateral (left and right) incision, including skin, muscle, and peritoneum were performed 2 cm below the last rib, and the left and right ovaries or left and right adrenals were extirpated [ovariectomy D1 (10), D2 (10), P (9) or E (10)]; [adrenalectomy D1 (10), D2 (12), P (10) or E (10)].
Localization (extirpated) of D2 in ovaries
16) Confidence 0.19 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2582036 Disease Relevance 0.39 Pain Relevance 0
A bilateral (left and right) incision, including skin, muscle, and peritoneum were performed 2 cm below the last rib, and the left and right ovaries or left and right adrenals were extirpated [ovariectomy D1 (10), D2 (10), P (9) or E (10)]; [adrenalectomy D1 (10), D2 (12), P (10) or E (10)].
Localization (extirpated) of D2 in ovaries
17) Confidence 0.19 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2582036 Disease Relevance 0.38 Pain Relevance 0
PURPOSE: This study was designed to test the hypothesis that the enzymatically stable opioid peptide, [D-pen2,5] enkephalin (DPDPE), is excreted extensively into bile.
Localization (excreted) of D-pen2 in bile associated with bile, enkephalin and opioid
18) Confidence 0.19 Published 1997 Journal Pharm. Res. Section Abstract Doc Link 9098878 Disease Relevance 0 Pain Relevance 0.40
Responses of each neuron to stimulation of three whiskers D1, D2 and D3 were recorded and stored on hard disk.


Localization (stimulation) of D2 in neuron
19) Confidence 0.18 Published 2006 Journal Neuroscience Section Body Doc Link PMC2860223 Disease Relevance 0.17 Pain Relevance 0.07
In SCWP rats responses to D2 whisker stimulation were not significantly different from those in SC rats in either supragranular or barrel neuron populations (P<0.1, MWU, in each case).
Localization (stimulation) of D2 in neuron
20) Confidence 0.18 Published 2006 Journal Neuroscience Section Body Doc Link PMC2860223 Disease Relevance 0 Pain Relevance 0

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