INT79545

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Context Info
Confidence 0.64
First Reported 1999
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 82
Total Number 83
Disease Relevance 39.42
Pain Relevance 12.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ESR1) enzyme binding (ESR1) DNA binding (ESR1)
protein complex (ESR1) cytoplasm (ESR1) signal transduction (ESR1)
Anatomy Link Frequency
MCF-7 4
neuronal 4
Neurons 4
pituitary 3
stroma 2
ESR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 125 100.00 Very High Very High Very High
agonist 483 99.84 Very High Very High Very High
spinal inflammation 81 99.34 Very High Very High Very High
backache 9 99.30 Very High Very High Very High
Infliximab 44 99.12 Very High Very High Very High
Inflammation 175 99.10 Very High Very High Very High
Cancer pain 14 98.80 Very High Very High Very High
addiction 36 98.52 Very High Very High Very High
cocaine 1175 98.08 Very High Very High Very High
Etanercept 115 97.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 455 100.00 Very High Very High Very High
Pain 132 100.00 Very High Very High Very High
Cancer 1554 99.98 Very High Very High Very High
Breast Cancer 1747 99.92 Very High Very High Very High
Neuroblastoma 8 99.72 Very High Very High Very High
Apoptosis 382 99.60 Very High Very High Very High
Polycystic Ovary Syndrome 18 99.58 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 178 99.52 Very High Very High Very High
Low Back Pain 91 99.34 Very High Very High Very High
Hypersensitivity 5 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A recent paper showed that an inducible expression of ER?
Positive_regulation (inducible) of Gene_expression (expression) of ER
1) Confidence 0.64 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0.50 Pain Relevance 0.03
A study has shown that the forced expression of ER?
Positive_regulation (forced) of Gene_expression (expression) of ER
2) Confidence 0.64 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0.52 Pain Relevance 0
We recently demonstrated that the reduction in endometrial beta 3 integrin expression in PCOS was associated with elevated expression of ER-alpha and an over-expression of steroid receptor coactivators [20].
Positive_regulation (elevated) of Gene_expression (expression) of ER associated with polycystic ovary syndrome
3) Confidence 0.62 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1679803 Disease Relevance 0.55 Pain Relevance 0.09
Therefore, we analyzed the binding of [3H]-diprenorphine in human neuroblastoma cells stably transfected with the estrogen receptor cDNA (SK-ER3 cell line).
Positive_regulation (transfected) of Gene_expression (transfected) of estrogen receptor cDNA associated with neuroblastoma
4) Confidence 0.50 Published 1999 Journal Neuroendocrinology Section Abstract Doc Link 9892851 Disease Relevance 0.17 Pain Relevance 0.25
Monoclonal antibodies (ERa: ER1D5 DAKO 1:35, PR: PGR636 DAKO 1:50, bcl-2: Clone 124 1:200 DAKO, EGFR: 31G7 CYTOMED 1:20, cerb2/Her-2/neu polyclonal DAKO 1:250, and ki67 (MIB-1) DAKO 1:200) were used for specific epitope detection.
Positive_regulation (used) of Gene_expression (antibodies) of ERa
5) Confidence 0.49 Published 2005 Journal J Transl Med Section Body Doc Link PMC1201176 Disease Relevance 0.41 Pain Relevance 0
In contrast, the improvement of PGA, PhGA, VAS, ESR and CRP was not significantly different between groups.
Positive_regulation (improvement) of Gene_expression (improvement) of ESR associated with pain
6) Confidence 0.49 Published 2008 Journal Clin. Rheumatol. Section Abstract Doc Link 18030515 Disease Relevance 0.93 Pain Relevance 1.12
In the 'ovarian-type' stroma, several genes involved in estrogen metabolism were overexpressed including STAR and ESR1 genes.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of ESR1 in stroma
7) Confidence 0.49 Published 2004 Journal Oncogene Section Abstract Doc Link 15489895 Disease Relevance 0.60 Pain Relevance 0.07
Integrated genome analysis of ER- and ER+ ERBB2-amplified tumors
Positive_regulation (Integrated) of Gene_expression (analysis) of ER associated with cancer
8) Confidence 0.46 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.10 Pain Relevance 0
Upregulated ESR1, GATA3, ERBB4, TFF1 and TFF3 gene expression was associated with ER+ ERBB2-amplified tumors.
Positive_regulation (Upregulated) of Gene_expression (expression) of ESR1 associated with cancer
9) Confidence 0.46 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.96 Pain Relevance 0
Two clinical trials have been published demonstrating the effectiveness of oxymorphone ER for the treatment of chronic cancer pain.
Positive_regulation (effectiveness) of Gene_expression (effectiveness) of oxymorphone ER associated with cancer pain
10) Confidence 0.44 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621383 Disease Relevance 0.75 Pain Relevance 2.05
In this case, however, the failure to down-regulate ER-alpha may be due to a hypersensitivity to estrogen, as evidenced by the over-expression of steroid receptor coactivators and ER-alpha itself [20].
Positive_regulation (over) of Gene_expression (expression) of ER associated with hypersensitivity
11) Confidence 0.41 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1679803 Disease Relevance 0.62 Pain Relevance 0.13
-negative, expressing ER?)
Positive_regulation (negative) of Gene_expression (expressing) of ER
12) Confidence 0.41 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0.35 Pain Relevance 0
For testing the effect of decursin, estrogen-deprived MCF-7 cells were pre-treated with decursin for 2 hours and were stimulated with 1 nM 17?
Positive_regulation (stimulated) of Gene_expression (pre) of estrogen in MCF-7
13) Confidence 0.41 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0.07 Pain Relevance 0
MCF-7 cells (expressing high levels of ER?)
Positive_regulation (levels) of Gene_expression (expressing) of ER in MCF-7
14) Confidence 0.41 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0.36 Pain Relevance 0
This dose of decursin abolished the phosphorylative activation of ERK1/2 by estradiol, and abolished the upregulation of the products of early estrogen-stimulated genes such as cyclin D1 (early G1 phase) and c-Myc.
Positive_regulation (upregulation) of Gene_expression (products) of estrogen
15) Confidence 0.41 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0 Pain Relevance 0.03
The hypothesis-generating study found that three of ten patients demonstrated ER overexpression at 9, 12, and 37 weeks, respectively, following the initiation of trastuzumab.
Positive_regulation (overexpression) of Gene_expression (overexpression) of ER
16) Confidence 0.38 Published 2007 Journal Breast Cancer Res Treat Section Body Doc Link PMC2001220 Disease Relevance 0.50 Pain Relevance 0
Indeed, some tumours that expressed high levels of ER were classified as belonging to group 2 or 3, ER-negative groups.
Positive_regulation (levels) of Gene_expression (expressed) of ER associated with cancer
17) Confidence 0.38 Published 2006 Journal Proteome Sci Section Body Doc Link PMC1456950 Disease Relevance 0.60 Pain Relevance 0
In MDA MB-231 cells, these compounds induced cell-cycle arrests in the G1 and G2 phases as well as inducing apoptosis, accompanied by an increased expression of ER?.
Positive_regulation (increased) of Gene_expression (expression) of ER associated with apoptosis
18) Confidence 0.38 Published 2007 Journal Breast Cancer Res Section Abstract Doc Link PMC2246173 Disease Relevance 0.60 Pain Relevance 0
A study of SAHA in combination with tamoxifen in women previously treated with an AI or tamoxifen is ongoing, the biological rationale for this study being that the HDAC inhibitor may restore endocrine sensitivity by restoring ER expression.
Positive_regulation (restoring) of Gene_expression (expression) of ER
19) Confidence 0.36 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2242654 Disease Relevance 0.51 Pain Relevance 0
Overexpression of ER?
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of ER
20) Confidence 0.33 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 1.07 Pain Relevance 0.04

General Comments

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