INT79553

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Context Info
Confidence 0.31
First Reported 1998
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 5.85
Pain Relevance 3.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il12a) extracellular region (Il12a) cytoplasm (Il12a)
Anatomy Link Frequency
blood 1
plasma 1
dendritic cells 1
Schwann cells 1
reticulum 1
Il12a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 45 100.00 Very High Very High Very High
Inflammation 25 100.00 Very High Very High Very High
COX2 15 99.62 Very High Very High Very High
chemokine 1 98.60 Very High Very High Very High
substance P 7 97.84 Very High Very High Very High
endometriosis 6 96.24 Very High Very High Very High
cINOD 5 95.60 Very High Very High Very High
metalloproteinase 1 95.04 Very High Very High Very High
Central nervous system 10 94.16 High High
corticosteroid 1 90.68 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 32 100.00 Very High Very High Very High
Cancer 7 100.00 Very High Very High Very High
Necrosis 4 100.00 Very High Very High Very High
Eosinophilia 2 99.48 Very High Very High Very High
Disease 6 99.00 Very High Very High Very High
Neurogenic Inflammation 1 98.38 Very High Very High Very High
Injury 22 97.34 Very High Very High Very High
Endometriosis 7 96.24 Very High Very High Very High
Toxicity 4 95.96 Very High Very High Very High
Headache 1 88.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Exposure of the vehicle rats to SSCS induced obvious pulmonary neurogenic inflammation as indicated by elevations in plasma extravasation and proinflammatory cytokine secretions [interieukin (IL)-1beta and IL-12].
Localization (secretions) of IL-12 in plasma associated with inflammation, neurogenic inflammation and cytokine
1) Confidence 0.31 Published 2004 Journal Toxicology Section Abstract Doc Link 15297018 Disease Relevance 0.31 Pain Relevance 0.81
Quality of life assessment, stool microbiologic studies, and blood sampling for estimation of peripheral blood mononuclear cell release of the cytokines interleukin (IL)-10 and IL-12 were performed at the beginning and at the end of the treatment phase.
Localization (release) of IL-12 in blood
2) Confidence 0.16 Published 2005 Journal Gastroenterology Section Body Doc Link 15765388 Disease Relevance 0.16 Pain Relevance 0
Largely, but not exclusively, through its effect on cyclic AMP, PGE2 can also: i) depress the expression of major histocompatibility complex class II antigens and of the costimulatory molecule B7-2; ii) down-regulate TNF and up-regulate IL-10 microglial production; iii) inhibit microglial IL-12 secretion.
Localization (secretion) of IL-12 in PGE2
3) Confidence 0.12 Published 1998 Journal Biochimie Section Abstract Doc Link 9893949 Disease Relevance 0.15 Pain Relevance 0.20
Injury-activated Schwann cells and resident macrophages are probably partly responsible for the recruitment of hematogenous macrophages by secreting MCP-1 [6] and the pro-inflammatory cytokines IL-1, IL-6, IL-12; and especially TNF-?
Localization (secreting) of IL-12 in Schwann cells associated with inflammation, injury and cytokine
4) Confidence 0.11 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1310517 Disease Relevance 0.88 Pain Relevance 0.38
In vitro, LBP has been demonstrated to induce maturation of murine bone marrow-derived dendritic cells to secrete IL-12 p40 and increase the expression of membrane markers I-A/I-E and CD11c [45].
Localization (secrete) of IL-12 p40 in dendritic cells
5) Confidence 0.04 Published 2009 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2723674 Disease Relevance 1.10 Pain Relevance 0.07
In this study, we show that both CE and an analog devoid of COX2 inhibitory activity [1-(4-sulfamoyl phenyl)-3-trifluoromethyl-5-(4-trifluoromethylphenyl)pyrazole, CEA] inhibit the secretion of the dimeric interleukin-12 (IL-12) alphabeta and beta2 forms with identical IC50 values of 20 and 30 microM, respectively, whereas no such effect was seen with rofecoxib.
Localization (secretion) of interleukin-12 associated with cox2
6) Confidence 0.04 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16467190 Disease Relevance 0.47 Pain Relevance 0.46
Celecoxib inhibits interleukin-12 alphabeta and beta2 folding and secretion by a novel COX2-independent mechanism involving chaperones of the endoplasmic reticulum.
Localization (secretion) of interleukin-12 in reticulum associated with cox2
7) Confidence 0.04 Published 2006 Journal Mol. Pharmacol. Section Title Doc Link 16467190 Disease Relevance 0.51 Pain Relevance 0.58
Biologic changes included lymphocytic infiltration, regional eosinophilia, tumor necrosis, and the localized production of IL-2, IFN-gamma and IL-12, demonstrated by in situ hybridization and immunohistochemistry.
Localization (localized) of IL-12 associated with necrosis, cancer and eosinophilia
8) Confidence 0.03 Published 2001 Journal Crit. Rev. Oncol. Hematol. Section Abstract Doc Link 11418300 Disease Relevance 1.02 Pain Relevance 0.18
The pathogenesis of endometriosis is still unclear and numerous immunological and inflammatory factors have been suggested to be involved in the development of the disease, including interleukin (IL)-1, IL-2, IL-6, IL-8, IL-12, tumour necrosis factor -alpha (TNF-alpha), regulated on activation, normal T-Cell expressed and secreted (RANTES) and its receptor cognate chemokine receptor 1 (CCR1), peroxisome proliferator activated receptors (PPARs), matrix metalloproteinases (MMPs) and cyclooxygenase (COX).
Localization (secreted) of IL-12 associated with chemokine, endometriosis, necrosis, inflammation, cancer, metalloproteinase and disease
9) Confidence 0.02 Published 2008 Journal Curr. Med. Chem. Section Abstract Doc Link 18393858 Disease Relevance 1.16 Pain Relevance 0.48

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