INT79556

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Context Info
Confidence 0.77
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 7.71
Pain Relevance 10.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GRIN3B)
Anatomy Link Frequency
blood 2
neurons 2
trigeminal ganglion 1
fibroblasts 1
oocytes 1
GRIN3B (Homo sapiens)
Pain Link Frequency Relevance Heat
nMDA receptor 119 100.00 Very High Very High Very High
agonist 26 100.00 Very High Very High Very High
nMDA receptor antagonist 9 100.00 Very High Very High Very High
Glutamate 60 99.98 Very High Very High Very High
antagonist 32 99.90 Very High Very High Very High
gABA 34 99.36 Very High Very High Very High
ketamine 17 99.36 Very High Very High Very High
Nerve growth factor 11 99.24 Very High Very High Very High
Opioid 36 98.84 Very High Very High Very High
addiction 16 98.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Schizophrenia 49 99.90 Very High Very High Very High
Stress 138 99.48 Very High Very High Very High
Opiate Addiction 20 98.84 Very High Very High Very High
Ganglion Cysts 3 98.12 Very High Very High Very High
Disease 58 97.00 Very High Very High Very High
Increased Venous Pressure Under Development 7 95.64 Very High Very High Very High
Pain 20 92.80 High High
Post-traumatic Stress Disorder 88 92.52 High High
Hemiplegia 1 92.24 High High
Deafness 1 91.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, it seems that the over-expression of NR3B subunit of NMDA receptor is a long lasting result of opioid abuse.
Gene_expression (over-expression) of NMDA receptor associated with nmda receptor and opioid
1) Confidence 0.77 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20153313 Disease Relevance 0.33 Pain Relevance 1.26
Expression of NR3B but not NR2D subunit of NMDA receptor in human blood lymphocytes can serve as a suitable peripheral marker for opioid addiction studies.
Gene_expression (Expression) of NMDA receptor in blood associated with addiction, nmda receptor and opioid
2) Confidence 0.77 Published 2010 Journal Eur. J. Pharmacol. Section Title Doc Link 20153313 Disease Relevance 0.30 Pain Relevance 0.96
Expression of NR3B but not NR2D subunit of NMDA receptor in human blood lymphocytes can serve as a suitable peripheral marker for opioid addiction studies.
Gene_expression (Expression) of NR3B in blood associated with addiction, nmda receptor and opioid
3) Confidence 0.77 Published 2010 Journal Eur. J. Pharmacol. Section Title Doc Link 20153313 Disease Relevance 0.24 Pain Relevance 0.90
However, it seems that the over-expression of NR3B subunit of NMDA receptor is a long lasting result of opioid abuse.
Gene_expression (over-expression) of NR3B subunit associated with nmda receptor and opioid
4) Confidence 0.77 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20153313 Disease Relevance 0.33 Pain Relevance 1.25
As a conclusion, our data indicate that the transcriptional level of the NR2D subunit of NMDA receptor is not regulated by chronic opioid addiction.
Gene_expression (level) of NMDA receptor associated with addiction, nmda receptor and opioid
5) Confidence 0.67 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20153313 Disease Relevance 0.33 Pain Relevance 1.25
On the other hand, neither GABA-benzodiazepine antagonists nor NMDA receptor agonists produce contradictory effects (i.e., reduce the ethanol discriminative stimulus).
Gene_expression (produce) of NMDA receptor associated with gaba, nmda receptor, antagonist and agonist
6) Confidence 0.49 Published 1999 Journal Alcohol Section Abstract Doc Link 9895039 Disease Relevance 0.06 Pain Relevance 0.65
Finally, the authors cite the progress achieved in the development of agents that interact with the glutamatergic system: NMDA channel blockers, competitive NMDA receptor antagonists, NR2B-selective antagonists, glutamate release inhibitors, glycineB antagonists, AMPA and kainate receptor antagonists, AMPA receptor-positive modulators and agents that act by modifying endogenous kynurenic acid metabolism.
Gene_expression (blockers) of NMDA receptor associated with glutamate, nmda receptor antagonist and antagonist
7) Confidence 0.20 Published 1998 Journal Drug News Perspect. Section Abstract Doc Link 15616669 Disease Relevance 1.30 Pain Relevance 0.69
METHODS: The human NR1A/NR2A NMDA receptor was expressed recombinantly in Xenopus laevis oocytes.
Gene_expression (expressed) of NMDA receptor in oocytes
8) Confidence 0.14 Published 2006 Journal Br J Anaesth Section Body Doc Link 16299047 Disease Relevance 0 Pain Relevance 0
Co-expression of the NR2B subunit of the NMDA receptor with P75 and TrkA NGF receptors by trigeminal ganglion neurons that innervate the masseter muscle was investigated immunohistochemically.
Gene_expression (Co-expression) of NMDA receptor in trigeminal ganglion associated with ganglion cysts, nerve growth factor, nmda receptor and trigeminal ganglion neurons
9) Confidence 0.14 Published 2010 Journal Pain Section Abstract Doc Link 20064691 Disease Relevance 0.23 Pain Relevance 0.89
Endothelin receptor subtype A (ETA) is predominantly found in smooth muscle and also on fibroblasts, whereas receptor subtype B (ETB) is expressed on smooth muscle and endothelial cells.19 Endothelial ETB activation mediates clearance of endothelin-1 and vasodilatation by nitric oxide and prostacyclin release.18 Because of these effects ETB activation is theoretically desirable in PAH.
Gene_expression (expressed) of receptor subtype B in fibroblasts associated with pulmonary hypertension and increased venous pressure under development
10) Confidence 0.09 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2725793 Disease Relevance 0.72 Pain Relevance 0.15
The NMDA receptor is thought to play a central role in the pathophysiology of schizophrenia and NMDA receptor dysfunction may underlie the behavioral and neurobiological deficits observed in this disease.
Gene_expression (dysfunction) of NMDA receptor associated with nmda receptor, disease and schizophrenia
11) Confidence 0.06 Published 2010 Journal The Open Medicinal Chemistry Journal Section Body Doc Link PMC2905773 Disease Relevance 0.93 Pain Relevance 0.72
The NMDA receptor is thought to play a central role in the pathophysiology of schizophrenia and NMDA receptor dysfunction may underlie the behavioral and neurobiological deficits observed in this disease.
Gene_expression (thought) of NMDA receptor associated with nmda receptor, disease and schizophrenia
12) Confidence 0.06 Published 2010 Journal The Open Medicinal Chemistry Journal Section Body Doc Link PMC2905773 Disease Relevance 0.97 Pain Relevance 0.67
In addition demonstration that NMDA triggered significant intracellular Ca2+ influx suggests that SB431542 generated neurons may be a good model with which to study the downstream physiological effects of various paradigms of NMDA receptor activation in human neurons, including synaptic plasticity, gene expression changes, as well as excitotoxicity.
Gene_expression (activation) of NMDA receptor in neurons associated with nmda receptor
13) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2752165 Disease Relevance 0 Pain Relevance 0.05
Glutamate-NMDA receptor pathway
Gene_expression (pathway) of NMDA receptor associated with glutamate and nmda receptor
14) Confidence 0.05 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0.81 Pain Relevance 0.28
However, the expression level of the NMDA receptor subunits NR2A and NR2B were massively over-expressed (more than 100%).
Gene_expression (expression) of NMDA receptor associated with nmda receptor
15) Confidence 0.02 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2518049 Disease Relevance 0.31 Pain Relevance 0.29
However, the expression level of the NMDA receptor subunits NR2A and NR2B were massively over-expressed (more than 100%).
Gene_expression (expressed) of NMDA receptor associated with nmda receptor
16) Confidence 0.02 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2518049 Disease Relevance 0.31 Pain Relevance 0.29
In fact, this hypothesis was supported by the observation that the NR1 subunit mRNA was upregulated in ketamine-treated monkey fetuses (gestation day 122) and infants (post natal day 5) compared with their controls, and increased expression of NMDA receptor NR1 protein in ketamine-treated neurons (in vitro monkey).
Gene_expression (expression) of NMDA receptor in neurons associated with ketamine and nmda receptor
17) Confidence 0.02 Published 2009 Journal Toxicological Sciences Section Body Doc Link PMC2769059 Disease Relevance 0.52 Pain Relevance 0.47

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