INT7956

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Context Info
Confidence 0.61
First Reported 1990
Last Reported 2010
Negated 7
Speculated 2
Reported most in Abstract
Documents 44
Total Number 46
Disease Relevance 8.26
Pain Relevance 29.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Th) mitochondrion (Th) nucleus (Th)
response to stress (Th) cytoplasm (Th)
Anatomy Link Frequency
neurons 12
brain 10
nucleus 6
hippocampus 6
medulla oblongata 5
Th (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 103 100.00 Very High Very High Very High
Catecholamine 61 100.00 Very High Very High Very High
Substantia nigra 45 100.00 Very High Very High Very High
narcan 40 100.00 Very High Very High Very High
Cannabinoid 27 100.00 Very High Very High Very High
Opioid 18 100.00 Very High Very High Very High
Dynorphin 14 100.00 Very High Very High Very High
Nucleus accumbens 9 100.00 Very High Very High Very High
opioid receptor 6 100.00 Very High Very High Very High
Neurotransmitter 6 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 4 100.00 Very High Very High Very High
Stress 21 99.82 Very High Very High Very High
Syndrome 7 99.76 Very High Very High Very High
Opiate Addiction 8 99.68 Very High Very High Very High
Affective Disorder 2 99.66 Very High Very High Very High
Aids-related Complex 8 98.98 Very High Very High Very High
Toxocariasis 29 98.20 Very High Very High Very High
Shock 5 97.40 Very High Very High Very High
Congenital Anomalies 9 96.80 Very High Very High Very High
Pain 2 96.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Regulation of tyrosine hydroxylase levels and activity and Fos expression during opioid withdrawal in the hypothalamic PVN and medulla oblongata catecholaminergic cell groups innervating the PVN.
Regulation (Regulation) of Gene_expression (expression) of tyrosine hydroxylase in medulla oblongata associated with medulla, narcan, withdrawal and opioid
1) Confidence 0.61 Published 2003 Journal Eur. J. Neurosci. Section Title Doc Link 12534973 Disease Relevance 0.40 Pain Relevance 1.09
Butyrate, a gut-derived environmental signal, regulates tyrosine hydroxylase gene expression via a novel promoter element.
Regulation (regulates) of Gene_expression (expression) of tyrosine hydroxylase in gut associated with enkephalin
2) Confidence 0.60 Published 2005 Journal Brain Res. Dev. Brain Res. Section Title Doc Link 16165221 Disease Relevance 0 Pain Relevance 0.23
The presence of the neuropeptide calcitonin gene-related peptide (CGRP) within the olfactory nerve has led to the hypothesis that CGRP is responsible for regulation of TH expression in the bulbar neurons.
Regulation (regulation) of Gene_expression (expression) of TH in neurons associated with neuropeptide and calcitonin gene-related peptide
3) Confidence 0.60 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1359472 Disease Relevance 0 Pain Relevance 0.41
In the olfactory bulb, expression of tyrosine hydroxylase (TH) in juxtaglomerular neurons is dependent on innervation by the olfactory nerve.
Regulation (dependent) of Gene_expression (expression) of TH in neurons
4) Confidence 0.60 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1359472 Disease Relevance 0 Pain Relevance 0.29
Differential regulation of c-fos, proenkephalin and tyrosine hydroxylase gene expression by metrazole in the hamster adrenal and hippocampus.
Regulation (regulation) of Gene_expression (expression) of tyrosine hydroxylase in hippocampus associated with enkephalin and hippocampus
5) Confidence 0.59 Published 1995 Journal Neurosci. Lett. Section Title Doc Link 7501282 Disease Relevance 0 Pain Relevance 0.31
Effects of opioid antagonism on prolactin secretion and c-Fos/TH expression during lactation in rats.
Regulation (Effects) of Gene_expression (expression) of TH associated with narcan and opioid
6) Confidence 0.56 Published 2004 Journal Endocrine Section Title Doc Link 15711026 Disease Relevance 0 Pain Relevance 0.63
The results indicate that chronic morphine regulates the expression of tyrosine hydroxylase specifically in the LC and suggest that such regulation reflects long-term adaptations of LC neurons to chronic morphine at the level of gene expression.
Regulation (regulates) of Gene_expression (expression) of tyrosine hydroxylase in neurons associated with locus ceruleus and morphine
7) Confidence 0.49 Published 1990 Journal J. Neurosci. Section Abstract Doc Link 1974920 Disease Relevance 0 Pain Relevance 1.21
Agmatine inhibited morphine-induced changes in dynorphin, but not in tyrosine hydroxylase mRNA expression.
Regulation (changes) of Gene_expression (expression) of tyrosine hydroxylase mRNA associated with dynorphin and morphine
8) Confidence 0.45 Published 2007 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 17604969 Disease Relevance 0 Pain Relevance 1.67
The differences in expression of TH mRNA and PPEnk mRNA in the adrenal medulla in situ, in explants in culture and in transplants in the spinal subarachnoid space, indicate that the mechanisms regulating the expression of neurohumoral factors depend upon environmental factors extrinsic to the medullary cells themselves.
Regulation (differences) of Gene_expression (expression) of TH mRNA in spinal associated with medulla
9) Confidence 0.45 Published 2000 Journal Exp. Neurol. Section Abstract Doc Link 10683300 Disease Relevance 0.10 Pain Relevance 0.51
Role of PKC-alpha,gamma isoforms in regulation of c-Fos and TH expression after naloxone-induced morphine withdrawal in the hypothalamic PVN and medulla oblongata catecholaminergic cell groups.
Regulation (regulation) of Gene_expression (expression) of TH in medulla oblongata associated with medulla, narcan, withdrawal and morphine
10) Confidence 0.45 Published 2005 Journal J. Neurochem. Section Title Doc Link 16190878 Disease Relevance 0.27 Pain Relevance 1.13
In the olfactory bulb, expression of tyrosine hydroxylase (TH) in juxtaglomerular neurons is dependent on innervation by the olfactory nerve.
Regulation (dependent) of Gene_expression (expression) of tyrosine hydroxylase in neurons
11) Confidence 0.44 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1359472 Disease Relevance 0 Pain Relevance 0.29
They also showed little or no change in staining for NPY, acetylcholinesterase (AChE) and tyrosine hydroxylase (TH) and essentially normal striatal gross morphology.
Neg (little) Regulation (change) of Gene_expression (staining) of TH
12) Confidence 0.42 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10648885 Disease Relevance 0 Pain Relevance 0.27
They also showed little or no change in staining for NPY, acetylcholinesterase (AChE) and tyrosine hydroxylase (TH) and essentially normal striatal gross morphology.
Neg (little) Regulation (change) of Gene_expression (staining) of tyrosine hydroxylase
13) Confidence 0.42 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10648885 Disease Relevance 0 Pain Relevance 0.27
Transsynaptic activity regulates proenkephalin and tyrosine hydroxylase gene expression and the response to reserpine in the hamster adrenal.
Regulation (regulates) of Gene_expression (expression) of tyrosine hydroxylase associated with enkephalin
14) Confidence 0.40 Published 1991 Journal Mol. Pharmacol. Section Title Doc Link 1717819 Disease Relevance 0 Pain Relevance 0.39
Our results show a severalfold increase in the relative abundance of TH and NPY mRNAs in response to a single immobilization.
Regulation (response) of Gene_expression (abundance) of TH
15) Confidence 0.40 Published 1996 Journal Endocrinology Section Abstract Doc Link 8940389 Disease Relevance 0.56 Pain Relevance 0.28
The aim of this study was to examine the differential regulation after acute ethanol administration on tyrosine hydroxylase, proenkephalin and cannabinoid CB(1) receptor gene expressions in selected areas of the rat brain.
Spec (examine) Regulation (regulation) of Gene_expression (expressions) of tyrosine hydroxylase in brain associated with cannabinoid
16) Confidence 0.37 Published 2008 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 17964122 Disease Relevance 0.09 Pain Relevance 0.37
We investigated whether cAMP-dependent protein kinase (PKA) plays a role in this process by estimating changes in PKA immunoreactivity and the influence of inhibition of PKA on Fos protein expression and tyrosine hydroxylase (TH) immunoreactivity levels in the PVN and NTS/VLM during morphine withdrawal.
Regulation (influence) of Gene_expression (expression) of tyrosine hydroxylase in VLM associated with medulla, withdrawal and morphine
17) Confidence 0.36 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15663473 Disease Relevance 0.45 Pain Relevance 1.42
Involvement of 3',5'-cyclic adenosine monophosphate-dependent protein kinase in regulation of Fos expression and tyrosine hydroxylase levels during morphine withdrawal in the hypothalamic paraventricular nucleus and medulla oblongata catecholaminergic cell groups.
Regulation (regulation) of Gene_expression (expression) of tyrosine hydroxylase in nucleus associated with medulla, adenocard, withdrawal and morphine
18) Confidence 0.36 Published 2005 Journal J. Neurochem. Section Title Doc Link 15663473 Disease Relevance 0.40 Pain Relevance 1.32
We investigated whether cAMP-dependent protein kinase (PKA) plays a role in this process by estimating changes in PKA immunoreactivity and the influence of inhibition of PKA on Fos protein expression and tyrosine hydroxylase (TH) immunoreactivity levels in the PVN and NTS/VLM during morphine withdrawal.
Regulation (influence) of Gene_expression (expression) of TH in VLM associated with medulla, withdrawal and morphine
19) Confidence 0.36 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15663473 Disease Relevance 0.45 Pain Relevance 1.42
The study implicates hormonal involvement in the stress-induced changes in TH, DBH, NPY, and proenkephalin gene expression in sympathetic ganglia.
Regulation (changes) of Gene_expression (expression) of TH in sympathetic associated with stress
20) Confidence 0.35 Published 1996 Journal Endocrinology Section Abstract Doc Link 8940389 Disease Relevance 0.61 Pain Relevance 0.28

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