INT79569

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 1.00
First Reported 1998
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.44
Pain Relevance 1.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PRKCA) mitochondrion (PRKCA) small molecule metabolic process (PRKCA)
endoplasmic reticulum (PRKCA) enzyme binding (PRKCA) cytoplasm (PRKCA)
Anatomy Link Frequency
neurons 1
lymphocyte 1
PRKCA (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 75 100.00 Very High Very High Very High
fluoxetine 12 99.42 Very High Very High Very High
adenocard 1 88.72 High High
Neurotransmitter 1 40.40 Quite Low
Central nervous system 10 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Neuronal excitability 2 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperplasia 1 98.64 Very High Very High Very High
Virus Diseases 89 97.30 Very High Very High Very High
Infection 29 77.52 Quite High
Borna Disease 4 50.00 Quite Low
Disease 6 5.00 Very Low Very Low Very Low
Neurological Disease 4 5.00 Very Low Very Low Very Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low
Cognitive Disorder 3 5.00 Very Low Very Low Very Low
Viral Infection 3 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This inhibitory effect involves PKC degradation and cAMP formation.
Protein_catabolism (degradation) of PKC associated with kinase c
1) Confidence 1.00 Published 1998 Journal Acta Physiol Pharmacol Ther Latinoam Section Abstract Doc Link 9914808 Disease Relevance 0.10 Pain Relevance 0.75
We found that fluoxetine promoted the Ca2+ -mediated proteolysis of protein kinase C (PKC) and increased cyclic-AMP (cAMP) levels, thereby impairing lymphocyte proliferation, when optimal concanavalin A concentrations were used.
Protein_catabolism (proteolysis) of PKC in lymphocyte associated with kinase c and fluoxetine
2) Confidence 0.86 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10374716 Disease Relevance 0 Pain Relevance 0.72
To determine the impact of the destruction of the PKC phosphorylation sites on BDV P, we directly stimulated the PKC pathway of neurons using the phorbol ester PMA and analyzed the phosphorylation status of two major PKC targets in neurons, myristoylated alanine-rich C kinase substrate (MARCKS) and synaptosomal-associated protein of 25 kDa (SNAP25) [32],[33].
Protein_catabolism (targets) of PKC in neurons associated with virus diseases and kinase c
3) Confidence 0.57 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 0.34 Pain Relevance 0.30

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox