INT79570

Context Info Confidence 0.32 First Reported 1999 Last Reported 2009 Negated 1 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 0.71 Pain Relevance 0.36

peptidase activity (Tpsab1) extracellular region (Tpsab1)

Anatomy Link Frequency glial cell 2 mast cell 2 Tpsab1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat chemokine 1 98.56 cytokine 1 97.96 Inflammation 5 97.56 cocaine 4 92.76 Angina 5 58.64 interstitial cystitis 2 50.00 Nerve growth factor 1 50.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Anaphylaxis 2 92.56 Myocardial Infarction 4 84.96 Emergencies 2 81.32 Arrhythmia Under Development 1 75.00 Heart Rate Under Development 1 65.16 Dyspnea 1 60.08 Angina 1 58.64 Interstitial Cystitis 2 50.00 Acute Coronary Syndrome 2 50.00 Bladder Cancer 1 50.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

CONCLUSION: Serum levels of tryptase are not elevated in patients with acute coronary syndromes.

Neg (not) Positive_regulation (elevated) of Gene_expression (levels) of tryptase

1) Confidence 0.32 Published 2001 Journal Int. J. Cardiol. Section Body Doc Link 11259815 Disease Relevance 0.06 Pain Relevance 0

Although preliminary due to the limited numbers of patients, they also suggest that increased levels of neurotrophin-3, nerve growth factor, glial cell line-derived neurotrophic factor and tryptase in the urine could serve as a basis for adjunct diagnosis, monitoring and treatment of interstitial cystitis.

Positive_regulation (increased) of Gene_expression (levels) of tryptase in glial cell

2) Confidence 0.31 Published 1999 Journal J. Urol. Section Body Doc Link 9915421 Disease Relevance 0 Pain Relevance 0

HYPOTHESIS: Acute coronary events (acute myocardial infarction and unstable angina pectoris) are associated with increased mast cell activity, reflected by elevated serum tryptase levels.

Positive_regulation (elevated) of Gene_expression (levels) of tryptase in mast cell

3) Confidence 0.28 Published 2001 Journal Int. J. Cardiol. Section Body Doc Link 11259815 Disease Relevance 0.09 Pain Relevance 0

Our hypothesis is supported by an elevated serum tryptase levels in the patient.

Positive_regulation (elevated) of Gene_expression (levels) of tryptase

4) Confidence 0.11 Published 2009 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 19505405 Disease Relevance 0.56 Pain Relevance 0.36

General Comments

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