INT79575

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Context Info
Confidence 0.02
First Reported 1999
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.77
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (NDUFA1) mitochondrion (NDUFA1) small molecule metabolic process (NDUFA1)
NDUFA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 5 55.24 Quite High
peripheral neuropathy 1 30.72 Quite Low
qutenza 1 25.68 Quite Low
headache 3 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Paresthesia 1 5.00 Very Low Very Low Very Low
dysesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leber Hereditary Optic Atrophy 27 100.00 Very High Very High Very High
Nicotine Addiction 6 98.90 Very High Very High Very High
Toxicity 1 88.88 High High
Disease 2 58.40 Quite High
Stress 1 51.16 Quite High
Nerve Degeneration 1 43.36 Quite Low
Sensorineural Hearing Loss 1 31.96 Quite Low
Peripheral Neuropathy 1 30.72 Quite Low
Deafness 1 26.16 Quite Low
Optic Disorders 4 25.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have developed two independent methods to measure equilibrium binding of inhibitors to membrane-bound and partially purified NADH:ubiquinone oxidoreductase (complex I) to characterize the binding sites for the great variety of hydrophobic compounds acting on this large and complicated enzyme.
complex I Binding (binding) of
1) Confidence 0.02 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 9915790 Disease Relevance 0 Pain Relevance 0
Solvents, their metabolites, and tobacco smoke derivatives (the patient was a moderate smoker) could interact with the biochemical defect related to the LHON mutation on complex I (Carelli et al. 2004).
mutation on complex I Binding (interact) of associated with leber hereditary optic atrophy and nicotine addiction
2) Confidence 0.01 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1797843 Disease Relevance 0.77 Pain Relevance 0.03

General Comments

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