INT79602

Context Info Confidence 0.19 First Reported 1999 Last Reported 1999 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 1.05 Pain Relevance 1.01

cytoplasm (PSMA5, Oprd1) nucleoplasm (PSMA5) small molecule metabolic process (PSMA5) signal transducer activity (Oprd1) cytosol (PSMA5) peptidase activity (PSMA5)

PSMA5 (Homo sapiens) Oprd1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Opioid 6 100.00 opioid receptor 5 100.00 Enkephalin 2 72.12 Endogenous opioid 2 71.04

Disease Link Frequency Relevance Heat Neuroblastoma 4 98.72 Pancreatic Cancer 4 98.72 Disease 1 64.88 Cancer 2 62.40 Precursor Cell Lymphoblastic Leukemia-lymphoma 1 62.08 Solid Tumor 1 59.44 Malignant Neoplastic Disease 1 54.68 Adenocarcinoma 1 53.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These data suggest that a native opioid peptide, OGF, interacts with a novel opioid receptor, zeta, to arrest the growth of human neuroblastoma.

zeta Binding (interacts) of opioid peptide associated with neuroblastoma, opioid receptor and opioid

1) Confidence 0.19 Published 1999 Journal Int. J. Oncol. Section Abstract Doc Link 9917516 Disease Relevance 0.55 Pain Relevance 0.54

These data suggest that a native opioid peptide, OGF, interacts with a novel opioid receptor, zeta, to arrest the growth of human pancreatic cancer.

zeta Binding (interacts) of opioid peptide associated with pancreatic cancer, opioid receptor and opioid

2) Confidence 0.12 Published 1999 Journal Int. J. Oncol. Section Abstract Doc Link 10024694 Disease Relevance 0.50 Pain Relevance 0.48

General Comments

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