INT79606

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Context Info
Confidence 0.59
First Reported 1998
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 0.31
Pain Relevance 2.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NAT2) small molecule metabolic process (NAT2) transferase activity, transferring acyl groups (NAT2)
cytoplasm (NAT2)
NAT2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 27 99.86 Very High Very High Very High
Serotonin 66 95.12 Very High Very High Very High
rheumatoid arthritis 63 60.20 Quite High
methotrexate 39 51.16 Quite High
Inflammation 15 40.76 Quite Low
adenocard 3 39.88 Quite Low
cytokine 28 5.00 Very Low Very Low Very Low
Infliximab 18 5.00 Very Low Very Low Very Low
Etanercept 18 5.00 Very Low Very Low Very Low
Adalimumab 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 10 77.44 Quite High
Rheumatoid Arthritis 64 60.20 Quite High
Rheumatic Diseases 1 56.32 Quite High
Graft Vs Host Disease 1 53.52 Quite High
INFLAMMATION 18 40.76 Quite Low
Disease 17 5.00 Very Low Very Low Very Low
Bardet-biedl Syndrome 6 5.00 Very Low Very Low Very Low
Lymphatic System Cancer 5 5.00 Very Low Very Low Very Low
Opportunistic Infections 4 5.00 Very Low Very Low Very Low
Demyelinating Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Acetaminophen is an inhibitor of hepatic N-acetyltransferase 2 in vitro and in vivo.
Negative_regulation (inhibitor) of hepatic N-acetyltransferase 2 associated with paracetamol
1) Confidence 0.59 Published 1998 Journal Pharmacogenetics Section Title Doc Link 9918139 Disease Relevance 0 Pain Relevance 0.60
Acetaminophen, a widely used over-the-counter drug, which shares structural similarities with acetylated products, inhibits NAT2 both in vitro and in vivo.
Negative_regulation (inhibits) of NAT2 associated with paracetamol
2) Confidence 0.51 Published 1998 Journal Pharmacogenetics Section Abstract Doc Link 9918139 Disease Relevance 0 Pain Relevance 0.66
Since concomitant administration of drugs may inhibit NAT2, we studied the influence of acetaminophen on NAT2 in human hepatic cytosol in vitro and in healthy individuals.
Spec (may) Negative_regulation (inhibit) of NAT2 associated with paracetamol
3) Confidence 0.43 Published 1998 Journal Pharmacogenetics Section Abstract Doc Link 9918139 Disease Relevance 0 Pain Relevance 0.43
Therefore, we make the hypothesis that UVA radiation leads to an inhibition of N-acetyltransferase via a cutaneous pathway [41].
Negative_regulation (inhibition) of N-acetyltransferase
4) Confidence 0.43 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC113771 Disease Relevance 0 Pain Relevance 0.19
It has recently been reported that UVA radiation is a powerful signal affecting the pineal melatonin-generating system and inhibits N-acetyltransferase [33,38,39].
Negative_regulation (inhibits) of N-acetyltransferase
5) Confidence 0.31 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC113771 Disease Relevance 0 Pain Relevance 0.16
The wild-type NAT2*4 allele encodes the rapid acetylator status; though there are a large number of NAT2 variants, those for NAT2*5A, NAT2*5B, NAT2*5C, NAT2*6 and NAT2*7, which consist of several SNP combinations in exon 2 of the gene, are the most common variants that encode the slow acetylator status by means of decreased activity of the NAT2 enzyme.
Negative_regulation (decreased) of NAT2
6) Confidence 0.20 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691664 Disease Relevance 0.31 Pain Relevance 0.06

General Comments

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