INT79609

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Context Info
Confidence 0.49
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.60
Pain Relevance 2.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos2) signal transduction (Nos2) extracellular space (Nos2)
aging (Nos2) peroxisome (Nos2) nucleus (Nos2)
Anatomy Link Frequency
neuronal 2
Nos2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 2 100.00 Very High Very High Very High
allodynia 1 99.72 Very High Very High Very High
Thermal hyperalgesia 2 99.16 Very High Very High Very High
ischemia 17 98.88 Very High Very High Very High
nociceptor 1 97.80 Very High Very High Very High
cva 42 96.16 Very High Very High Very High
opioid receptor 3 92.56 High High
Intracerebroventricular 1 90.96 High High
Endogenous opioid 3 90.76 High High
intrathecal 1 88.68 High High
Disease Link Frequency Relevance Heat
Arthritis 9 99.84 Very High Very High Very High
Neuropathic Pain 1 99.72 Very High Very High Very High
Hyperalgesia 2 99.16 Very High Very High Very High
Cv Unclassified Under Development 16 98.88 Very High Very High Very High
Hemorrhage 43 96.16 Very High Very High Very High
Stress 11 94.80 High High
Ocular Hypertension 1 91.04 High High
Ganglion Cysts 1 90.64 High High
Retina Disease 1 89.76 High High
Nociception 2 87.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mucosal expression levels of eNOS and iNOS but not nNOS mRNAs were enhanced in arthritic rats compared with normal rats.
Positive_regulation (enhanced) of Negative_regulation (levels) of iNOS associated with arthritis
1) Confidence 0.49 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19881222 Disease Relevance 1.15 Pain Relevance 0.20
Naltrexone induced a pronounced dose-dependent reduction in iNOS mRNA and protein expression by splenocytes.
Positive_regulation (induced) of Negative_regulation (reduction) of iNOS mRNA
2) Confidence 0.44 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9918551 Disease Relevance 0 Pain Relevance 0.48
I.t. pretreatment of IL-1 receptor antagonist (IL-1ra), p38 MAPK inhibitor or iNOS inhibitor, inhibits the i.t.
Positive_regulation (pretreatment) of Negative_regulation (inhibitor) of iNOS associated with antagonist
3) Confidence 0.41 Published 2007 Journal Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists Section Abstract Doc Link 17694686 Disease Relevance 0.70 Pain Relevance 0.94
Previous work showed that iNOS is upregulated early after H/R and that selective iNOS inhibitors are protective [26-28].
Positive_regulation (protective) of Negative_regulation (inhibitors) of iNOS
4) Confidence 0.36 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2936410 Disease Relevance 0.72 Pain Relevance 0.32
Additional groups of rats received NG-nitro-L-arginine and NG-monomethyl-L-arginin, non-selective NO synthase inhibitors, 7-nitroindazole, a neuronal NOS inhibitor, and aminoguanidine and L-N6-(1-iminoethyl) lysine, inducible NO synthase (iNOS) inhibitors before preconditioning, and were subjected to 60 min of ischemia.
Positive_regulation (received) of Neg (NO) Negative_regulation (inhibitors) of iNOS in neuronal associated with ischemia
5) Confidence 0.35 Published 2006 Journal Exp. Eye Res. Section Abstract Doc Link 16198335 Disease Relevance 1.03 Pain Relevance 0.47

General Comments

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