INT79618

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Context Info
Confidence 0.17
First Reported 1999
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (POMC) cell-cell signaling (POMC) cytoplasm (POMC)
signal transducer activity (Htr1a) extracellular space (POMC) generation of precursor metabolites and energy (POMC)
Htr1a (Rattus norvegicus)
POMC (Homo sapiens)
Pain Link Frequency Relevance Heat
fluoxetine 9 97.16 Very High Very High Very High
agonist 1 78.16 Quite High
Withdrawal 3 49.28 Quite Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Long-term exposure to fluoxetine produces a desensitization of hypothalamic postsynaptic 5-hydroxytryptamine (5-HT)1A receptors, indicated by a substantial inhibition of the 5-HT1A receptor-mediated stimulation of oxytocin and adrenocorticotropic hormone (ACTH) secretion.
5-HT1A Positive_regulation (stimulation) of adrenocorticotropic hormone associated with fluoxetine
1) Confidence 0.17 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9918559 Disease Relevance 0 Pain Relevance 0.39

General Comments

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