INT79626

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Context Info
Confidence 0.42
First Reported 1999
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.36
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

CRYGS (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 2 98.28 Very High Very High Very High
agonist 10 97.20 Very High Very High Very High
antagonist 4 95.28 Very High Very High Very High
Sumatriptan 4 89.80 High High
gABA 1 89.04 High High
Opioid 3 87.28 High High
mu opioid receptor 1 86.32 High High
Kappa opioid receptor 2 80.00 Quite High
Migraine 1 46.24 Quite Low
fortral 1 44.08 Quite Low
Disease Link Frequency Relevance Heat
Bordatella Infection 1 98.76 Very High Very High Very High
Glioma 3 77.36 Quite High
Increased Venous Pressure Under Development 1 51.04 Quite High
Coronary Artery Disease 1 5.00 Very Low Very Low Very Low
Headache 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The G(i)/G(o)-protein alkylating agent N-ethylmaleimide decreased basal [35S]GTPgammaS binding in a concentration-dependent manner and inhibited the stimulation induced by the different agonists.
Negative_regulation (decreased) of GTPgammaS Binding (binding) of associated with agonist
1) Confidence 0.42 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10708703 Disease Relevance 0 Pain Relevance 0.40
The stimulation of [35S]GTPgammaS binding was blocked by pretreatment of cells with pertussis toxin.
Negative_regulation (blocked) of GTPgammaS Binding (binding) of associated with bordatella infection
2) Confidence 0.05 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9918595 Disease Relevance 0.25 Pain Relevance 0.37
SB-224289, which decreased [35S]GTPgammaS binding when given alone, but not GR-127935, was more potent in antagonizing the stimulatory effect of 5-CT on [35S]GTPgammaS binding to membranes expressing the VR compared to membranes expressing the WTR.
Negative_regulation (decreased) of GTPgammaS Binding (binding) of
3) Confidence 0.02 Published 2000 Journal Pharmacogenetics Section Abstract Doc Link 11037806 Disease Relevance 0.11 Pain Relevance 0.51

General Comments

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