INT79635

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Context Info
Confidence 0.74
First Reported 1999
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.26
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp1a2) endoplasmic reticulum (Cyp1a2) enzyme binding (Cyp1a2)
Cyp1a2 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 19 100.00 Very High Very High Very High
Inflammation 2 94.96 High High
Bioavailability 1 64.08 Quite High
Potency 3 47.80 Quite Low
Bile 1 32.32 Quite Low
Central nervous system 7 5.00 Very Low Very Low Very Low
Glutamate 7 5.00 Very Low Very Low Very Low
antidepressant 5 5.00 Very Low Very Low Very Low
nMDA receptor 3 5.00 Very Low Very Low Very Low
Hippocampus 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 2 94.96 High High
Hepatotoxicity 3 93.96 High High
Injury 4 75.00 Quite High
Disease 167 50.00 Quite Low
Toxicity 4 25.00 Low Low
Cognitive Disorder 55 5.00 Very Low Very Low Very Low
Dementia 34 5.00 Very Low Very Low Very Low
Vascular Dementia 16 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 14 5.00 Very Low Very Low Very Low
Adverse Drug Reaction 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The pretreatment regimen resulted in hepatic changes including: centrilobular localization of 3-(cysteine-S-yl)APAP protein adducts, selective down-regulation of cytochrome P4502E1 (CYP2E1) and CYP1A2 that produced the toxic metabolite, N-acetyl-p-benzoquinone imine, higher levels of reduced glutathione (GSH), centrilobular inflammation, and a fourfold increase in hepatocellular proliferation.
Localization (localization) of CYP1A2 associated with paracetamol and inflammation
1) Confidence 0.74 Published 1999 Journal Hepatology Section Abstract Doc Link 9918922 Disease Relevance 0.26 Pain Relevance 0.93
Donepezil potentially may interact with drugs metabolized via CYP1A2-, CYP2D6-, and CYP3A4-related enzymes; however, formal pharmacokinetic studies have revealed no clinically meaningful interactions with memantine, risperidone, sertraline, carbidopa/levodopa, theophylline, furosemide, cimetidine, warfarin, and digoxin (Tiseo et al 1998a, b, c, d, e, f; Seltzer 2005).
Localization (metabolized) of CYP1A2
2) Confidence 0.31 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654795 Disease Relevance 0 Pain Relevance 0.03

General Comments

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