INT79656

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Context Info
Confidence 0.68
First Reported 1999
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 6.38
Pain Relevance 10.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NR3C1) nucleoplasm (NR3C1) signal transduction (NR3C1)
aging (NR3C1) nucleolus (NR3C1) nucleus (NR3C1)
Anatomy Link Frequency
spinal 2
peripheral nerve 2
hepatocytes 1
DP thymocytes 1
nucleus 1
NR3C1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Peripheral nerve injury 6 99.98 Very High Very High Very High
Cannabinoid 3 99.76 Very High Very High Very High
Glutamate 8 99.60 Very High Very High Very High
antagonist 47 99.48 Very High Very High Very High
Spinal cord 16 99.48 Very High Very High Very High
Dorsal horn 13 99.00 Very High Very High Very High
Morphine 39 98.84 Very High Very High Very High
Inflammation 89 98.66 Very High Very High Very High
substance P 9 98.28 Very High Very High Very High
COX2 2 97.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 25 99.98 Very High Very High Very High
Repression 1 99.28 Very High Very High Very High
Injury 18 99.02 Very High Very High Very High
INFLAMMATION 95 98.66 Very High Very High Very High
Apoptosis 110 95.44 Very High Very High Very High
Neuropathic Pain 4 91.40 High High
Fibrosis 22 87.00 High High
Pain 5 80.60 Quite High
Arthritis 37 80.24 Quite High
Nociception 1 79.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prevention of the GR upregulation with GR antisense oligonucleotides as well as inhibition of GR activation with the GR antagonist RU38486 effectively prevented the exacerbated morphine tolerance after subsequent cycles of morphine exposure.
Positive_regulation (activation) of GR associated with antagonist, tolerance and morphine
1) Confidence 0.68 Published 2005 Journal Pain Section Abstract Doc Link 15733634 Disease Relevance 0 Pain Relevance 2.13
Mechanistically, morphine exposure induced a cyclic AMP and protein kinase A-dependent upregulation of neuronal glucocorticoid receptors (GR) within the spinal cord dorsal horn, which was maintained after discontinuation of morphine administration and significantly enhanced upon a second cycle of morphine exposure.
Positive_regulation (upregulation) of GR in spinal cord dorsal horn associated with dorsal horn, spinal cord and morphine
2) Confidence 0.68 Published 2005 Journal Pain Section Abstract Doc Link 15733634 Disease Relevance 0 Pain Relevance 2.08
Prevention of the GR upregulation with GR antisense oligonucleotides as well as inhibition of GR activation with the GR antagonist RU38486 effectively prevented the exacerbated morphine tolerance after subsequent cycles of morphine exposure.
Positive_regulation (upregulation) of GR associated with antagonist, tolerance and morphine
3) Confidence 0.68 Published 2005 Journal Pain Section Abstract Doc Link 15733634 Disease Relevance 0 Pain Relevance 2.15
Previous studies have shown that peripheral nerve injury upregulated both glucocorticoid receptors (GR) and cannabinoid-1 receptors (CB1R) within the spinal cord dorsal horn in rats.
Positive_regulation (upregulated) of GR in peripheral nerve associated with nervous system injury, cannabinoid, dorsal horn, spinal cord and peripheral nerve injury
4) Confidence 0.47 Published 2007 Journal Pain Section Abstract Doc Link 17258396 Disease Relevance 0.54 Pain Relevance 0.39
Previous studies have shown that glucocorticoid receptors (GR) were upregulated, whereas glutamate transporters were downregulated, within the spinal cord dorsal horn after peripheral nerve injury.
Positive_regulation (upregulated) of GR in peripheral nerve associated with glutamate, nervous system injury, dorsal horn, peripheral nerve injury and spinal cord
5) Confidence 0.25 Published 2006 Journal Pain Section Abstract Doc Link 16360273 Disease Relevance 0.45 Pain Relevance 0.37
Agents highly lipophilic will demonstrate a higher and faster rate of uptake by the nasal mucous membrane, a higher level of retention within the nasal tissue, and an enhanced ability to reach the glucocorticoid receptor.
Positive_regulation (reach) of glucocorticoid receptor in nasal
6) Confidence 0.23 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504057 Disease Relevance 0.07 Pain Relevance 0.35
Enhancement of phosphorylation and transcriptional activity of the glucocorticoid receptor in human synovial fibroblasts by nimesulide, a preferential cyclooxygenase 2 inhibitor.
Positive_regulation (Enhancement) of glucocorticoid receptor in fibroblasts associated with cox2
7) Confidence 0.17 Published 1999 Journal Arthritis Rheum. Section Title Doc Link 9920026 Disease Relevance 0.09 Pain Relevance 0.19
Since, NF-kappaB has been shown to regulate the expression of those cellular elements linked to inflammation and tissue injury and its activity can be negatively regulated by GR activation, these results suggest that spinal GR through NF-kappaB may play a significant role in the regulation of EAAC1 expression after peripheral nerve injury, a cellular pathway that may contribute to the development of neuropathic pain behaviors in rats.
Positive_regulation (activation) of GR in spinal associated with nervous system injury, inflammation, injury, neuropathic pain and peripheral nerve injury
8) Confidence 0.17 Published 2006 Journal Pain Section Abstract Doc Link 16360273 Disease Relevance 0.77 Pain Relevance 0.53
The finding that VPA was an effective inhibitor of HDACs arose from observations that valproic acid was able to relieve transcriptional repression of a peroxisomal proliferation and activation of a glucocorticoid receptor (GR)-PPAR?
Positive_regulation (activation) of glucocorticoid receptor associated with repression
9) Confidence 0.12 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 0.52 Pain Relevance 0
In the nucleus, the activated cGCR leads to induction or inhibition of transcription of specific regulator proteins.
Positive_regulation (activated) of cGCR in nucleus
10) Confidence 0.08 Published 2008 Journal International Journal of Nanomedicine Section Body Doc Link PMC2626937 Disease Relevance 1.01 Pain Relevance 0.73
Treatment with 30 ng/kg VAA-I for 4 days elevated the GCR level (mean fluorescence intensity) in DP thymocytes (70).
Positive_regulation (elevated) of GCR in DP thymocytes
11) Confidence 0.06 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1062151 Disease Relevance 0.75 Pain Relevance 0.21
Glucocorticoids produce their effect on responsive cells by activating the glucocorticoid receptor (GR) to directly or indirectly regulate the transcription of target genes.
Positive_regulation (activating) of glucocorticoid receptor
12) Confidence 0.06 Published 2008 Journal Interdisciplinary Toxicology Section Body Doc Link PMC2993477 Disease Relevance 1.09 Pain Relevance 0.52
The glucocorticoid receptor in rat hepatocytes is activated by UDCA in a ligand-independent way, whereas suppression of IFN-?
Positive_regulation (activated) of glucocorticoid receptor in hepatocytes
13) Confidence 0.02 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 0.93 Pain Relevance 0.40
Using this selectivity of GR 205171 for NKA-induced NK-1 receptor activation, we examined the relative contribution of SP and NKA to noxious stimulus-induced activation of spinal NK-1 receptors.
Positive_regulation (activation) of GR 205171 in spinal associated with substance p
14) Confidence 0.00 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11331395 Disease Relevance 0.16 Pain Relevance 0.77

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