INT79658

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Context Info
Confidence 0.68
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 3.59
Pain Relevance 2.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GSR) mitochondrion (GSR) small molecule metabolic process (GSR)
oxidoreductase activity (GSR) cytoplasm (GSR)
Anatomy Link Frequency
blood cells 2
plasma 1
liver 1
nucleus 1
HSF 1
GSR (Homo sapiens)
Pain Link Frequency Relevance Heat
antidepressant 3 99.68 Very High Very High Very High
dexamethasone 19 98.24 Very High Very High Very High
COX2 2 98.00 Very High Very High Very High
Paracetamol 166 97.50 Very High Very High Very High
cytokine 13 97.34 Very High Very High Very High
cINOD 1 96.96 Very High Very High Very High
fluoxetine 1 88.48 High High
Desipramine 1 87.44 High High
depression 10 81.84 Quite High
Inflammation 21 72.32 Quite High
Disease Link Frequency Relevance Heat
Manic Depressive Disorder 33 96.76 Very High Very High Very High
INFLAMMATION 24 96.68 Very High Very High Very High
Depression 19 95.24 Very High Very High Very High
Affective Disorder 72 94.68 High High
Hepatotoxicity 18 94.32 High High
Attention Deficit Hyperactivity Disorder 1 78.92 Quite High
Sepsis 33 78.68 Quite High
Injury 83 78.16 Quite High
Decapitation 4 74.68 Quite High
Mental Disorders 6 72.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Matsubara and colleagues recently found evidence of reduced mRNA expression of GR-alpha (the GR isoform which binds glucocorticoids) in peripheral blood cells of patients with bipolar disorder and in patients with major depressive disorder, both while depressed as well as in remission.
Transcription (expression) of GR in blood cells associated with depression and manic depressive disorder
1) Confidence 0.68 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656301 Disease Relevance 0.88 Pain Relevance 0.03
These antidepressants did not affect GR-mediated transcription by themselves, but significantly inhibited dexamethasone-induced transcription.
Transcription (transcription) of GR-mediated associated with antidepressant and dexamethasone
2) Confidence 0.52 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12757900 Disease Relevance 0.16 Pain Relevance 0.36
Matsubara and colleagues recently found evidence of reduced mRNA expression of GR-alpha (the GR isoform which binds glucocorticoids) in peripheral blood cells of patients with bipolar disorder and in patients with major depressive disorder, both while depressed as well as in remission.
Transcription (expression) of GR in blood cells associated with depression and manic depressive disorder
3) Confidence 0.51 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656301 Disease Relevance 0.94 Pain Relevance 0.03
A post-mortem study of bipolar patients showed decreased expression of GR mRNA (Perlman et al 2004; Webster et al 2002) and an exaggerated responses to the dex/CRH test in healthy first degree relatives of mood disorder patients has been found (Lauer et al 1998).
Transcription (expression) of GR associated with affective disorder
4) Confidence 0.51 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656301 Disease Relevance 0.34 Pain Relevance 0
Potential mechanisms for cytokine-induced reduction in GR function and affinity may include inhibition of GR translocation from cytoplasm to nucleus and reduction in GR-mediated gene transcription [68].
Transcription (transcription) of GR-mediated in nucleus associated with cytokine
5) Confidence 0.40 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.38 Pain Relevance 0.15
OBJECTIVE: To examine the effect of 2 nonsteroidal antiinflammatory drugs (NSAIDs), nimesulide (NIM), a preferential cyclooxygenase 2 (COX-2) inhibitor, and naproxen (NAP), on the functional parameters and transcriptional activity of the glucocorticoid receptor (GR) system in cultured human synovial fibroblasts (HSF).
Transcription (activity) of GR in HSF associated with inflammation, cinod and cox2
6) Confidence 0.38 Published 1999 Journal Arthritis Rheum. Section Abstract Doc Link 9920026 Disease Relevance 0.10 Pain Relevance 0.18
, the splicing event leading to the formation of the GR?
Transcription (formation) of GR
7) Confidence 0.26 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0 Pain Relevance 0
By itself, APAP increased MDA formation and had a significant lowering influence on the levels of GSH and GSSG, the GSH/GSSH ratio, and the activities of GR, GST and GCS both in the plasma and liver.
Transcription (activities) of GR in plasma associated with paracetamol
8) Confidence 0.14 Published 2010 Journal J Biomed Sci Section Abstract Doc Link PMC2994383 Disease Relevance 0.40 Pain Relevance 0.72
By itself, APAP increased MDA formation and had a significant lowering influence on the levels of GSH and GSSG, the GSH/GSSH ratio, and the activities of GR, GST and GCS both in the plasma and liver.
Transcription (activities) of GR in liver associated with paracetamol
9) Confidence 0.05 Published 2010 Journal J Biomed Sci Section Abstract Doc Link PMC2994383 Disease Relevance 0.40 Pain Relevance 0.72

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