INT79660

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Context Info
Confidence 0.80
First Reported 1999
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.45
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PSMC6) nucleoplasm (PSMC6) small molecule metabolic process (PSMC6)
ATPase activity (PSMC6) nucleus (PSMC6) protein binding, bridging (PSMC6)
PSMC6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 12 99.84 Very High Very High Very High
Enkephalin 1 98.90 Very High Very High Very High
Potency 2 97.78 Very High Very High Very High
opioid receptor 3 75.00 Quite High
mu opioid receptor 1 75.00 Quite High
agonist 1 75.00 Quite High
Pain 4 65.12 Quite High
analgesia 1 59.28 Quite High
orphanin 1 54.76 Quite High
COX2 2 50.00 Quite Low
Disease Link Frequency Relevance Heat
Death 1 98.24 Very High Very High Very High
Apoptosis 2 90.72 High High
Toxicity 1 81.64 Quite High
Pain 1 65.12 Quite High
Hepatocellular Cancer 4 54.08 Quite High
Cancer 2 43.40 Quite Low
INFLAMMATION 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mitogen-activated protein kinase p44/42 (MAPK) phosphorylation was followed by Western analysis using a specific anti-phosphoMAPK antibody.
Phosphorylation (phosphorylation) of p44
1) Confidence 0.80 Published 1999 Journal Arthritis Rheum. Section Body Doc Link 9920026 Disease Relevance 0 Pain Relevance 0
Furthermore, inhibition of the p44/42-MAPK phosphorylation by HAAP could abolish the DOX-induced cell death pathway.
Phosphorylation (phosphorylation) of p44 associated with paracetamol and death
2) Confidence 0.80 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17526808 Disease Relevance 0.39 Pain Relevance 0.78
Second messenger assays further indicate that formation of ORL1/muR heterodimer selectively induces cross-desensitization of muR and impairs the potency by which [D-Ala(2),N-methyl-Phe(4),Gly-ol(5)]enkephalin (DAMGO) inhibits adenylate cyclase and stimulates p42/p44 mitogen-activated protein kinase (MAPK) phosphorylation.
Phosphorylation (phosphorylation) of p44 associated with enkephalin and potency
3) Confidence 0.35 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15748148 Disease Relevance 0.07 Pain Relevance 0.51

General Comments

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