INT79671

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Context Info
Confidence 0.32
First Reported 1999
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.25
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neutrophil 2
Pbrgcsf1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 69 99.24 Very High Very High Very High
peripheral neuropathy 5 97.72 Very High Very High Very High
bDMF 15 91.28 High High
positron emission tomography 3 77.20 Quite High
Eae 6 43.16 Quite Low
Analgesic 2 19.92 Low Low
Inflammation 22 16.72 Low Low
cINOD 4 13.36 Low Low
Central nervous system 2 10.08 Low Low
headache 2 10.00 Low Low
Disease Link Frequency Relevance Heat
Hematological Disease 21 99.80 Very High Very High Very High
Infection 35 99.68 Very High Very High Very High
Cv Unclassified Under Development 33 99.24 Very High Very High Very High
Peripheral Neuropathy 5 97.72 Very High Very High Very High
Apoptosis 24 96.98 Very High Very High Very High
Diarrhoea 3 94.00 High High
Stress 3 93.40 High High
Emergencies 1 93.00 High High
Neutropenia 11 91.52 High High
Mucositis 3 90.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
G-CSF expression is often induced during infection and is thought to play an important role in the regulation of the systemic and local neutrophil response to the infection [34], a process known as stress or emergency granulopoiesis.
Positive_regulation (induced) of Gene_expression (expression) of G-CSF in neutrophil associated with stress, emergencies and infection
1) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904706 Disease Relevance 1.12 Pain Relevance 0
In contrast, G-CSF or EPO+G-CSF injection did not stimulate the additive upregulation of serum EPO in the Tg-HIF-1?
Neg (not) Positive_regulation (stimulate) of Gene_expression (injection) of G-CSF
2) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852409 Disease Relevance 0.40 Pain Relevance 0.16
The anti-apoptotic protein Bcl-2 was significantly upregulated in EPO+G-CSF, EPO, and G-CSF groups, compared with control group (Fig. 4J), and the EPO+G-CSF combination induced significantly greater expression of Bcl-2 than EPO or G-CSF alone 24 hr after ischemia (Fig. 4J).
Positive_regulation (induced) of Gene_expression (expression) of G-CSF associated with ischemia and apoptosis
3) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852409 Disease Relevance 0.49 Pain Relevance 0.21
In contrast, G-CSF or EPO+G-CSF injection did not stimulate the additive upregulation of serum EPO in the Tg-HIF-1?
Neg (not) Positive_regulation (stimulate) of Gene_expression (injection) of G-CSF
4) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852409 Disease Relevance 0.40 Pain Relevance 0.15
Because NA-BMCs are not a homogenous cell population, remaining MSCs are also able to support host hematopoiesis, e.g. by induction of G-CSF production.
Positive_regulation (induction) of Gene_expression (production) of G-CSF associated with hematological disease
5) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2701999 Disease Relevance 0.23 Pain Relevance 0
No patients received G-CSF with both primary or secondary prophylactic aim.
Neg (No) Positive_regulation (received) of Neg (No) Gene_expression (received) of G-CSF
6) Confidence 0.15 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1475875 Disease Relevance 1.60 Pain Relevance 0.05
Sixty normal subjects were given injections of G-CSF or GM-CSF alone; GM-CSF and G-CSF concurrently for 4, 5, or 6 days; or a sequential regimen of GM-CSF for 3 or 4 days followed by G-CSF for 2 or 3 days.
Positive_regulation (injections) of Gene_expression (injections) of G-CSF
7) Confidence 0.13 Published 1999 Journal Transfusion Section Body Doc Link 9920165 Disease Relevance 0 Pain Relevance 0
Sixty normal subjects were given injections of G-CSF or GM-CSF alone; GM-CSF and G-CSF concurrently for 4, 5, or 6 days; or a sequential regimen of GM-CSF for 3 or 4 days followed by G-CSF for 2 or 3 days.
Positive_regulation (injections) of Gene_expression (injections) of G-CSF
8) Confidence 0.13 Published 1999 Journal Transfusion Section Body Doc Link 9920165 Disease Relevance 0 Pain Relevance 0

General Comments

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