INT79680

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.47
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 10
Disease Relevance 2.83
Pain Relevance 3.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grm7) Golgi apparatus (Grm7) plasma membrane (Grm7)
neurological system process (Grm7) protein complex (Grm7) signal transducer activity (Grm7)
Anatomy Link Frequency
cerebellar granule cell 1
neuronal 1
Grm7 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuronal excitability 1 100.00 Very High Very High Very High
agonist 253 99.34 Very High Very High Very High
antagonist 346 99.24 Very High Very High Very High
Kinase C 7 98.76 Very High Very High Very High
Glutamate 177 97.16 Very High Very High Very High
GABAergic 1 95.20 Very High Very High Very High
Central nervous system 7 88.80 High High
amygdala 4 87.00 High High
Eae 61 85.84 High High
Pain 3 85.36 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 41 100.00 Very High Very High Very High
Appetite Loss 5 98.72 Very High Very High Very High
Congenital Anomalies 27 91.84 High High
Toxicity 1 86.64 High High
Pain 4 85.36 High High
Anxiety Disorder 49 83.60 Quite High
Disease 3 83.28 Quite High
Cancer 2 83.04 Quite High
Parkinsonian Disorders 1 75.00 Quite High
Shock 1 71.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunoprecipitation showed that the PICK1-mGluR7a interaction is disrupted in mGluR7a(AAA/AAA) mice.
mGluR7 Binding (interaction) of
1) Confidence 0.47 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18716219 Disease Relevance 0.39 Pain Relevance 0.27
In cerebellar granule cell cultures, the group III mGluR agonist l-AP-4 decreased the frequency of spontaneous excitatory currents in neurons derived from wild-type but not mGluR7a(AAA/AAA) mice, consistent with the interaction between mGluR7a and PICK1 being required for protein kinase C-mediated inhibition of glutamate release.
mGluR7 Binding (interaction) of in cerebellar granule cell associated with glutamate, kinase c and agonist
2) Confidence 0.36 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18716219 Disease Relevance 0.48 Pain Relevance 0.40
In contrast, mGluR7(-/-) knockout mice failed to associate between the taste and the negative reinforcer in CTA experiments.
mGluR7 Binding (associate) of associated with appetite loss and targeted disruption
3) Confidence 0.34 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 9920659 Disease Relevance 1.44 Pain Relevance 0.34
Here we characterize the functional action of a new orthosteric group III mGlu agonist, LSP1-2111, with a preferential affinity for mGlu4 receptor.
mGlu4 receptor Binding (affinity) of associated with agonist
4) Confidence 0.04 Published 2009 Journal FASEB J. Section Abstract Doc Link 19525404 Disease Relevance 0.16 Pain Relevance 0.40
The Group I mGlu receptor, mGlu5, is well positioned to regulate and fine-tune neuronal excitability and synaptic transmission through its modulation of various signal transduction pathways and interactions with other transmitter systems.
mGlu receptor Binding (interactions) of in neuronal associated with neuronal excitability
5) Confidence 0.01 Published 2005 Journal Curr Top Med Chem Section Abstract Doc Link 16178734 Disease Relevance 0.24 Pain Relevance 0.43
Compound 8 containing an indole ring shows a low micromole affinity for the mGlu1 receptor, and pyridine ring fused indole derivatives 9 is also a low affinity mGlu1 receptor antagonist [133, 134].
mGlu1 receptor Binding (affinity) of associated with antagonist
6) Confidence 0.00 Published 2010 Journal The Open Medicinal Chemistry Journal Section Body Doc Link PMC3002053 Disease Relevance 0.06 Pain Relevance 0.34
Pyrazine analog 14 also shows high binding affinity for the mGlu1 receptor (IC50 = 6 nM) [143].
mGlu1 receptor Binding (affinity) of
7) Confidence 0.00 Published 2010 Journal The Open Medicinal Chemistry Journal Section Body Doc Link PMC3002053 Disease Relevance 0.07 Pain Relevance 0.20
A series of patents were published on benzodiazepine derivative 3, which reportedly had a very low nanomolar affinity for the mGlu 2 receptor [114].
mGlu 2 receptor Binding (affinity) of
8) Confidence 0.00 Published 2010 Journal The Open Medicinal Chemistry Journal Section Body Doc Link PMC3002053 Disease Relevance 0 Pain Relevance 0.37
Recently, a structurally different mGlu 2 receptor antagonist, imidazole 6, was disclosed (binding affinity for mGlu 2 receptor (IC50= 7nM) [120].
mGlu 2 receptor Binding (affinity) of associated with antagonist
9) Confidence 0.00 Published 2010 Journal The Open Medicinal Chemistry Journal Section Body Doc Link PMC3002053 Disease Relevance 0 Pain Relevance 0.44
Thiazolopyrimidine derivatives showed moderate binding affinity for the mGlu 2 receptor, while pyrrazolopyrimidine had low nanomolar affinity.
mGlu 2 receptor Binding (affinity) of
10) Confidence 0.00 Published 2010 Journal The Open Medicinal Chemistry Journal Section Body Doc Link PMC3002053 Disease Relevance 0 Pain Relevance 0.39

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox