INT79681

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Context Info
Confidence 0.78
First Reported 1999
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.57
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grm7) Golgi apparatus (Grm7) plasma membrane (Grm7)
neurological system process (Grm7) protein complex (Grm7) signal transducer activity (Grm7)
Anatomy Link Frequency
brain 2
neurons 1
glutamatergic neurons 1
Grm7 (Mus musculus)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 17 100.00 Very High Very High Very High
Glutamate receptor 16 100.00 Very High Very High Very High
amygdala 6 100.00 Very High Very High Very High
Neurotransmitter 4 97.52 Very High Very High Very High
agonist 6 87.04 High High
Morphine 54 77.68 Quite High
Glutamate 6 75.00 Quite High
Kinase C 3 69.76 Quite High
Eae 5 69.12 Quite High
Pain 4 67.72 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 16 96.52 Very High Very High Very High
Toxicity 1 92.08 High High
Congenital Anomalies 3 89.68 High High
Appetite Loss 5 87.20 High High
Cancer 3 85.76 High High
Anxiety Disorder 10 75.00 Quite High
Sprains And Strains 71 74.96 Quite High
Pain 4 67.72 Quite High
Shock 4 54.64 Quite High
Aggression 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the synaptic localization of mGluR7a was not altered in cultured hippocampal neurons and brain sections prepared from the knock-in animals.
Localization (localization) of mGluR7 in brain associated with targeted disruption
1) Confidence 0.78 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18716219 Disease Relevance 0.45 Pain Relevance 0.31
Immunohistochemical and immunoelectron-microscopic analyses showed that mGluR7 is highly expressed in amygdala and preferentially localized at the presynaptic axon terminals of glutamatergic neurons.
Localization (localized) of mGluR7 in glutamatergic neurons associated with amygdala
2) Confidence 0.76 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 9920659 Disease Relevance 1.25 Pain Relevance 0.32
The metabotropic glutamate receptor 7 (mGluR7) is widely expressed throughout the brain and primarily localized at presynaptic active zones, where it is thought to regulate neurotransmitter release.
Localization (localized) of mGluR7 in brain associated with neurotransmitter and glutamate receptor
3) Confidence 0.73 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18716219 Disease Relevance 0.23 Pain Relevance 0.14
Significant LRS close to transcript position, which is an indication of cis-acting variations (LRS > 32.2, LOD > 7), was found for Atp1a2 (1434893_at, LRS = 65.48 and 1455136_at, LRS = 121.4), Kcnj9 (1450712_at, LRS = 65.22), Comt (1418701_at, LRS = 59.20 and 1449183_at, LRS = 44.95) and Grm7 (1459532_at, LRS = 33.51).
Spec (found) Localization (found) of Grm7 associated with catechol-o-methyltransferase and glutamate receptor
4) Confidence 0.71 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1553451 Disease Relevance 0.19 Pain Relevance 0.27
However, the synaptic localization of mGluR7a was not altered in cultured hippocampal neurons and brain sections prepared from the knock-in animals.
Localization (localization) of mGluR7 in neurons associated with targeted disruption
5) Confidence 0.26 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18716219 Disease Relevance 0.45 Pain Relevance 0.31

General Comments

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