INT79682

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Context Info
Confidence 0.75
First Reported 1999
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 8
Disease Relevance 4.74
Pain Relevance 4.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grm7) Golgi apparatus (Grm7) plasma membrane (Grm7)
neurological system process (Grm7) protein complex (Grm7) signal transducer activity (Grm7)
Anatomy Link Frequency
covering 1
neurons 1
brain 1
DRG 1
central nervous system 1
Grm7 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 39 100.00 Very High Very High Very High
amygdala 10 99.84 Very High Very High Very High
dorsal root ganglion 5 99.68 Very High Very High Very High
analgesia 22 99.64 Very High Very High Very High
Central nervous system 1 99.24 Very High Very High Very High
Dorsal horn neuron 2 97.36 Very High Very High Very High
Inflammation 11 96.88 Very High Very High Very High
Neurotransmitter 4 95.72 Very High Very High Very High
Neuropathic pain 2 95.72 Very High Very High Very High
agonist 5 91.16 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 5 99.68 Very High Very High Very High
Nociception 3 97.76 Very High Very High Very High
Cognitive Disorder 3 97.72 Very High Very High Very High
Sprains And Strains 213 97.04 Very High Very High Very High
INFLAMMATION 7 96.88 Very High Very High Very High
Neuropathic Pain 5 95.72 Very High Very High Very High
Toxicity 1 92.08 High High
Congenital Anomalies 5 89.68 High High
Targeted Disruption 14 88.52 High High
Appetite Loss 5 87.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The metabotropic glutamate receptor 7 (mGluR7) is widely expressed throughout the brain and primarily localized at presynaptic active zones, where it is thought to regulate neurotransmitter release.
Gene_expression (expressed) of mGluR7 in brain associated with neurotransmitter and glutamate receptor
1) Confidence 0.75 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18716219 Disease Relevance 0.22 Pain Relevance 0.14
Immunohistochemical and immunoelectron-microscopic analyses showed that mGluR7 is highly expressed in amygdala and preferentially localized at the presynaptic axon terminals of glutamatergic neurons.
Gene_expression (expressed) of mGluR7 in glutamatergic neurons associated with amygdala
2) Confidence 0.74 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 9920659 Disease Relevance 1.25 Pain Relevance 0.31
Grm7 expression measured by qPCR showed significantly higher level in 129P3/J mice versus DBA/2J and SWR/J strains (p < 0.01) (Figure 3A).
Gene_expression (expression) of Grm7 associated with glutamate receptor and sprains and strains
3) Confidence 0.73 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1553451 Disease Relevance 0.55 Pain Relevance 0.37
Signal from the microarray probe-set 1459532_at covering 3' region of metabotropic glutamate receptor 7 (Grm7) was detected only in DBA/2J mice (Figure 3B).
Gene_expression (region) of Grm7 in covering associated with glutamate receptor
4) Confidence 0.63 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1553451 Disease Relevance 0.56 Pain Relevance 0.34
However, the differences observed in metabotropic glutamate receptor 7 gene expression is more difficult to interpret due to the lack of correlation between array and qPCR results.
Gene_expression (expression) of glutamate receptor 7 gene associated with glutamate receptor
5) Confidence 0.49 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1553451 Disease Relevance 0.28 Pain Relevance 0.84
Recent studies have indicated that metabotropic glutamate receptors mGluR5, mGluR2/3 and mGluR7 are present in the regions of central nervous system important for nociceptive transmission, but their involvement in neuropathic pain has not been well established.
Gene_expression (present) of mGluR7 in central nervous system associated with nociception, glutamate receptor, neuropathic pain and central nervous system
6) Confidence 0.40 Published 2008 Journal Pain Section Abstract Doc Link 18442882 Disease Relevance 0.70 Pain Relevance 1.00
We conclude that HDAC inhibition produces analgesia by up-regulating mGlu2 receptor expression in the DRG, an effect that results from the amplification of NF-kappaB transcriptional activity.
Gene_expression (expression) of mGlu2 receptor in DRG associated with dorsal root ganglion and analgesia
7) Confidence 0.00 Published 2009 Journal Mol. Pharmacol. Section Abstract Doc Link 19255242 Disease Relevance 0.63 Pain Relevance 0.93
This potentiation is not associated with increased mGlu1 or mGlu5 receptor expression but is associated with increased levels of phosphorylated ERK in dorsal horn neurons.
Gene_expression (expression) of mGlu5 receptor in neurons associated with dorsal horn neuron
8) Confidence 0.00 Published 2004 Journal Pain Section Abstract Doc Link 15327816 Disease Relevance 0.56 Pain Relevance 0.57

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