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Context Info
Confidence 0.41
First Reported 1999
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.22
Pain Relevance 1.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grm7) Golgi apparatus (Grm7) plasma membrane (Grm7)
neurological system process (Grm7) protein complex (Grm7) signal transducer activity (Grm7)
Anatomy Link Frequency
amygdala 1
Grm7 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 14 100.00 Very High Very High Very High
antagonist 6 100.00 Very High Very High Very High
amygdala 6 98.48 Very High Very High Very High
Central nervous system 2 98.20 Very High Very High Very High
Morphine 54 92.44 High High
Opioid 23 89.76 High High
Neuronal excitability 1 87.48 High High
Potency 2 87.12 High High
Analgesic 9 86.80 High High
Catechol-O-methyltransferase 17 85.76 High High
Disease Link Frequency Relevance Heat
Toxicity 1 98.80 Very High Very High Very High
Cognitive Disorder 1 98.28 Very High Very High Very High
Congenital Anomalies 3 96.40 Very High Very High Very High
Targeted Disruption 7 95.24 Very High Very High Very High
Disease 2 95.08 Very High Very High Very High
Appetite Loss 5 93.92 High High
Anxiety Disorder 7 75.00 Quite High
Pain 2 74.44 Quite High
Neurological Disease 2 70.32 Quite High
Aggression 2 68.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that mGluR7 deficiency causes an impairment of two distinct amygdala-dependent behavioral paradigms.
Negative_regulation (deficiency) of mGluR7 in amygdala associated with amygdala
1) Confidence 0.41 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 9920659 Disease Relevance 1.35 Pain Relevance 0.34
Deletion of Grm7 gene in mice produces a selective working memory impairment [45].
Negative_regulation (Deletion) of Grm7 associated with cognitive disorder and glutamate receptor
2) Confidence 0.41 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1553451 Disease Relevance 0.30 Pain Relevance 0.89
The discovery of MPEP 3, a non-competitive mGlu5 receptor antagonist, provided a potent, selective, systemically active tool compound for proof of concept studies in animal models of various disease states.
Negative_regulation (antagonist) of mGlu5 receptor associated with antagonist and disease
3) Confidence 0.01 Published 2005 Journal Curr Top Med Chem Section Abstract Doc Link 16178734 Disease Relevance 0.58 Pain Relevance 0.53

General Comments

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