INT79685

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Context Info
Confidence 0.70
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 14.63
Pain Relevance 11.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pparg) signal transduction (Pparg) nucleus (Pparg)
enzyme binding (Pparg) DNA binding (Pparg) cytoplasm (Pparg)
Anatomy Link Frequency
neurons 8
astrocytes 8
brains 2
dorsal horn 2
Pparg (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 32 100.00 Very High Very High Very High
COX2 3 100.00 Very High Very High Very High
cOX1 1 100.00 Very High Very High Very High
noradrenaline 64 99.98 Very High Very High Very High
Dorsal horn 1 99.98 Very High Very High Very High
intrathecal 1 99.84 Very High Very High Very High
cINOD 57 99.04 Very High Very High Very High
Inflammation 49 97.88 Very High Very High Very High
cytokine 8 95.80 Very High Very High Very High
antagonist 20 94.32 High High
Disease Link Frequency Relevance Heat
Non-small-cell Lung Cancer 18 99.84 Very High Very High Very High
Disease 64 99.36 Very High Very High Very High
Cancer 56 98.04 Very High Very High Very High
INFLAMMATION 69 97.88 Very High Very High Very High
Alzheimer's Dementia 6 97.48 Very High Very High Very High
Neuroblastoma 2 92.08 High High
Hypersensitivity 1 91.52 High High
Pain 4 90.88 High High
Nervous System Injury 2 88.88 High High
Small Cell Lung Cancer 3 86.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Noradrenaline induces expression of peroxisome proliferator activated receptor gamma (PPARgamma) in murine primary astrocytes and neurons.
Positive_regulation (induces) of Gene_expression (expression) of PPARgamma in astrocytes associated with noradrenaline
1) Confidence 0.70 Published 2003 Journal J. Neurochem. Section Title Doc Link 12887689 Disease Relevance 0.84 Pain Relevance 0.76
Increased expression of PPARgamma, as well as ciglitazone and sulindac sulfide induced expression of E-cadherin, which has been linked to increased differentiation of NSCLC.
Positive_regulation (Increased) of Gene_expression (expression) of PPARgamma associated with non-small-cell lung cancer
2) Confidence 0.62 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12391285 Disease Relevance 0.95 Pain Relevance 0.55
Overexpression of PPARgamma in NSCLC cells strongly inhibited the transformed growth properties of the cells, providing a molecular confirmation of the results obtained with the PPARgamma agonists.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of PPARgamma associated with non-small-cell lung cancer and agonist
3) Confidence 0.62 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12391285 Disease Relevance 0.98 Pain Relevance 0.55
Incubation of astrocytes and neurons with 100 micro m NA resulted in an increase of PPARgamma mRNA as well as PPARgamma protein levels in both cell types.
Positive_regulation (resulted) of Gene_expression (levels) of PPARgamma in neurons associated with noradrenaline
4) Confidence 0.50 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12887689 Disease Relevance 0.86 Pain Relevance 0.92
Noradrenaline induces expression of peroxisome proliferator activated receptor gamma (PPARgamma) in murine primary astrocytes and neurons.
Positive_regulation (induces) of Gene_expression (expression) of peroxisome proliferator activated receptor gamma in astrocytes associated with noradrenaline
5) Confidence 0.50 Published 2003 Journal J. Neurochem. Section Title Doc Link 12887689 Disease Relevance 0.84 Pain Relevance 0.75
Incubation of astrocytes and neurons with 100 micro m NA resulted in an increase of PPARgamma mRNA as well as PPARgamma protein levels in both cell types.
Positive_regulation (increase) of Gene_expression (levels) of PPARgamma in neurons associated with noradrenaline
6) Confidence 0.50 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12887689 Disease Relevance 0.86 Pain Relevance 0.92
between MMTV-PyV mice and the mice, generated by crossing PPARg+/?
Positive_regulation (generated) of Gene_expression (crossing) of PPARg
7) Confidence 0.46 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 1.16 Pain Relevance 0
Increased expression of PPARgamma, as well as ciglitazone and sulindac sulfide induced expression of E-cadherin, which has been linked to increased differentiation of NSCLC.
Positive_regulation (Increased) of Gene_expression (expression) of PPARgamma associated with non-small-cell lung cancer
8) Confidence 0.45 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12391285 Disease Relevance 0.95 Pain Relevance 0.55
Noradrenaline induces expression of peroxisome proliferator activated receptor gamma (PPARgamma) in murine primary astrocytes and neurons.
Positive_regulation (induces) of in neurons Gene_expression (expression) of PPARgamma in astrocytes associated with noradrenaline
9) Confidence 0.24 Published 2003 Journal J. Neurochem. Section Title Doc Link 12887689 Disease Relevance 0.84 Pain Relevance 0.76
Increased expression of cyclooxygenases and peroxisome proliferator-activated receptor-gamma in Alzheimer's disease brains.
Positive_regulation (Increased) of Gene_expression (expression) of peroxisome proliferator-activated receptor-gamma in brains associated with disease and cox1
10) Confidence 0.18 Published 1999 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 9920782 Disease Relevance 0.79 Pain Relevance 0.43
Addition of ibuprofen, indomethacin, peroxisome proliferator-activated receptor-gamma (PPARgamma) agonists, or cotransfection with PPARgamma cDNA reversed this effect.
Positive_regulation (proliferator-activated) of Gene_expression (cotransfection) of peroxisome proliferator-activated receptor-gamma associated with agonist
11) Confidence 0.17 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 14586007 Disease Relevance 0.87 Pain Relevance 0.75
Addition of ibuprofen, indomethacin, peroxisome proliferator-activated receptor-gamma (PPARgamma) agonists, or cotransfection with PPARgamma cDNA reversed this effect.
Positive_regulation (cotransfection) of Gene_expression (cotransfection) of peroxisome proliferator-activated receptor-gamma associated with agonist
12) Confidence 0.17 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 14586007 Disease Relevance 0.87 Pain Relevance 0.75
Noradrenaline induces expression of peroxisome proliferator activated receptor gamma (PPARgamma) in murine primary astrocytes and neurons.
Positive_regulation (induces) of in neurons Gene_expression (expression) of peroxisome proliferator activated receptor gamma in astrocytes associated with noradrenaline
13) Confidence 0.17 Published 2003 Journal J. Neurochem. Section Title Doc Link 12887689 Disease Relevance 0.84 Pain Relevance 0.75
Incubation of astrocytes and neurons with 100 micro m NA resulted in an increase of PPARgamma mRNA as well as PPARgamma protein levels in both cell types.
Positive_regulation (increase) of in astrocytes Gene_expression (levels) of PPARgamma in neurons associated with noradrenaline
14) Confidence 0.17 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12887689 Disease Relevance 0.86 Pain Relevance 0.92
Incubation of astrocytes and neurons with 100 micro m NA resulted in an increase of PPARgamma mRNA as well as PPARgamma protein levels in both cell types.
Positive_regulation (resulted) of in astrocytes Gene_expression (levels) of PPARgamma in neurons associated with noradrenaline
15) Confidence 0.17 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12887689 Disease Relevance 0.86 Pain Relevance 0.92
In contrast to the peripheral site of action of PPARalpha ligands, the dorsal horn supports the expression of PPARgamma.
Positive_regulation (supports) of Gene_expression (expression) of PPARgamma in dorsal horn associated with dorsal horn
16) Confidence 0.12 Published 2009 Journal Brain research reviews Section Abstract Doc Link 19162071 Disease Relevance 0.88 Pain Relevance 0.78
These results are generally consistent with what has been observed in conjunction with the overexpression of adipogenesis- and osteogenesis-related transcription factors, including RXR, osteonectin, AP, and PPAR-gamma, after de-differentiation (Figure 5A).
Positive_regulation (overexpression) of Gene_expression (overexpression) of PPAR-gamma
17) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2817727 Disease Relevance 0.36 Pain Relevance 0

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