INT79689

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Context Info
Confidence 0.62
First Reported 1999
Last Reported 2011
Negated 1
Speculated 4
Reported most in Body
Documents 10
Total Number 17
Disease Relevance 8.04
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PPARG) enzyme binding (PPARG) DNA binding (PPARG)
lipid metabolic process (PPARG) cytoplasm (PPARG) cytosol (PPARG)
Anatomy Link Frequency
adipocytes 2
liver 1
colon 1
striatum 1
brains 1
PPARG (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 158 100.00 Very High Very High Very High
cINOD 16 97.12 Very High Very High Very High
chemokine 2 86.60 High High
Inflammation 45 82.40 Quite High
addiction 2 78.04 Quite High
Dopamine 1 72.56 Quite High
Inflammatory response 5 71.88 Quite High
aspirin 5 42.64 Quite Low
agonist 46 34.48 Quite Low
cOX1 4 25.00 Low Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 50 99.96 Very High Very High Very High
Diabetes Mellitus 150 99.92 Very High Very High Very High
Colon Cancer 277 99.84 Very High Very High Very High
Disease 105 99.84 Very High Very High Very High
Apoptosis 31 99.28 Very High Very High Very High
Chronic Disease 2 98.96 Very High Very High Very High
Obesity 258 98.00 Very High Very High Very High
Cancer 259 97.68 Very High Very High Very High
Drug Induced Neurotoxicity 4 97.40 Very High Very High Very High
Cirrhosis 15 96.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We investigated whether PPARG is epigenetically regulated in colorectal cancer (CRC) progression.
Spec (whether) Regulation (regulated) of PPARG associated with colon cancer
1) Confidence 0.62 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2997072 Disease Relevance 0.53 Pain Relevance 0
The results obtained in 3T3-L1 preadipocytes and extended to the human gene, for structure and sequence similarities, suggest that also PPARG2 is regulated by DNA methylation [26].
Regulation (regulated) of PPARG2 in 3T3-L1
2) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.86 Pain Relevance 0
More recently, epigenetic regulation of Pparg has been invoked as an important step in mouse myofibroblast transdifferentiation of hepatic stellate cells that promotes liver fibrogenesis [22].
Regulation (regulation) of Pparg in liver associated with cirrhosis
3) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.91 Pain Relevance 0
Regarding the apoptotic rate, administration of TZD had no effect on the HT29 shPPARG clone, as compared to parental cells (Figure S4).
Neg (no) Regulation (effect) of shPPARG associated with apoptosis
4) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.45 Pain Relevance 0
PPARG SNPs may affect CHD risk through their association with cardiovascular risk factors.
Spec (may) Regulation (affect) of PPARG associated with coronary artery disease
5) Confidence 0.45 Published 2009 Journal PPAR Research Section Body Doc Link PMC2792957 Disease Relevance 0.60 Pain Relevance 0
gene (PPARG) has been implicated in the etiology of type 2 diabetes mellitus and has been investigated in numerous epidemiologic studies.
Regulation (implicated) of PPARG associated with diabetes mellitus
6) Confidence 0.45 Published 2010 Journal American Journal of Epidemiology Section Abstract Doc Link PMC2834889 Disease Relevance 0.29 Pain Relevance 0
As a positive control for COX2 and PPARG IHC, a colon carcinoma with known COX2 and PPARG expression was chosen.
Regulation (control) of PPARG in colon associated with colon cancer and cox2
7) Confidence 0.42 Published 2010 Journal PPAR Research Section Body Doc Link PMC2712952 Disease Relevance 0.15 Pain Relevance 0.32
Few studies have directly considered the real effect of PPARG variants on the PPARG expression itself and of its target genes, evaluating the alteration of its binding affinity to PPRE, the promoter efficiency, and other factors that may affect its transactivation ability [73–84].
Regulation (effect) of PPARG
8) Confidence 0.38 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 0.14 Pain Relevance 0
The molecular mechanisms underlying PPARG expression regulation in CRC progression are still unknown [9].
Regulation (regulation) of PPARG associated with colon cancer
9) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.49 Pain Relevance 0.04
PPARG is a known target for thiazolidinediones, antidiabetic drugs which have been shown to improve insulin sensitivity and to reduce plasma glucose and blood pressure in persons with type 2 diabetes (51).
Regulation (target) of PPARG in blood associated with diabetes mellitus
10) Confidence 0.27 Published 2010 Journal American Journal of Epidemiology Section Body Doc Link PMC2834889 Disease Relevance 0.61 Pain Relevance 0
Although the impact of common single nucleotide polymorphisms (SNPs) in PPARG gene on the expression of its target genes is not fully understood, an SNP and/or a combination of them (haplotype) may affect the PPARG transcript itself and in turn its ability to regulate gene expression [23].
Regulation (affect) of PPARG
11) Confidence 0.26 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 0 Pain Relevance 0
In light of this, deeply investigating PPARG—from DNA variations to gene expression and its regulation—will surely enhance our understanding about its involvement in health and disease.
Regulation (regulation) of PPARG associated with disease
12) Confidence 0.26 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 0.27 Pain Relevance 0
Interestingly, stromal cells in the tumoral microenvironment can also differ from their normal counterparts in the expression of biologically meaningful molecules [29] including also COX2 and PPARG expression.
Regulation (differ) of PPARG in stromal cells associated with cox2
13) Confidence 0.19 Published 2010 Journal PPAR Research Section Body Doc Link PMC2712952 Disease Relevance 0.89 Pain Relevance 0.29
Thus, expression levels of COX-1, COX-2, and PPARgamma may change in AD brains.
Spec (may) Regulation (change) of PPARgamma in brains associated with disease
14) Confidence 0.17 Published 1999 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9920782 Disease Relevance 0.72 Pain Relevance 0.33
We examined changes in nuclear peroxisome proliferator-activated receptor gamma (PPAR gamma) in the striatum in methamphetamine (METH)-induced dopaminergic neurotoxicity, and also examined effects of treatment with drugs possessing PPAR gamma agonistic properties.
Spec (examined) Regulation (changes) of PPAR gamma in striatum associated with drug induced neurotoxicity
15) Confidence 0.15 Published 2009 Journal Neurochem. Res. Section Abstract Doc Link 18946735 Disease Relevance 0.23 Pain Relevance 0.09
It is theorized that Irvingia gabonensis works by inhibiting adipogenesis by down-regulating peroxisome proliferator-activated receptor gamma (PPAR-gamma) which is responsible for the differentiation of adipocytes.
Regulation (regulating) of PPAR-gamma in adipocytes associated with obesity
16) Confidence 0.14 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2931392 Disease Relevance 0.45 Pain Relevance 0
It is theorized that Irvingia gabonensis works by inhibiting adipogenesis by down-regulating peroxisome proliferator-activated receptor gamma (PPAR-gamma) which is responsible for the differentiation of adipocytes.
Regulation (regulating) of peroxisome proliferator-activated receptor gamma in adipocytes associated with obesity
17) Confidence 0.14 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2931392 Disease Relevance 0.45 Pain Relevance 0

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