INT79691

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Context Info
Confidence 0.50
First Reported 1999
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 10
Total Number 21
Disease Relevance 10.44
Pain Relevance 1.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PPARG) enzyme binding (PPARG) DNA binding (PPARG)
lipid metabolic process (PPARG) cytoplasm (PPARG) cytosol (PPARG)
Anatomy Link Frequency
stromal cells 2
brains 2
microglial cells 2
PPARG (Homo sapiens)
PPARG - A12P (1)
Pain Link Frequency Relevance Heat
COX2 81 100.00 Very High Very High Very High
Dopamine 1 99.20 Very High Very High Very High
cINOD 24 99.00 Very High Very High Very High
Inflammation 48 98.38 Very High Very High Very High
agonist 59 95.36 Very High Very High Very High
aspirin 4 91.76 High High
chemokine 2 86.60 High High
addiction 1 78.04 Quite High
antagonist 22 75.96 Quite High
Inflammatory response 11 71.88 Quite High
Disease Link Frequency Relevance Heat
Colon Cancer 689 100.00 Very High Very High Very High
Cancer 408 100.00 Very High Very High Very High
Repression 68 100.00 Very High Very High Very High
Disease 79 99.84 Very High Very High Very High
Coronary Artery Disease 50 99.64 Very High Very High Very High
INFLAMMATION 76 98.38 Very High Very High Very High
Diabetes Mellitus 55 98.08 Very High Very High Very High
Cardiovascular Disease 2 97.04 Very High Very High Very High
Obesity 118 96.76 Very High Very High Very High
Overweight 11 96.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The four allelic variants of genes PTGS1, PLA2G2A, PPARG, and IL8 might favor inflammatory processes, whereas the MTHFR allelic variant could induce a DNA hypomethylation altering the expression of the putative tumor suppressor gene PPARG.
Regulation (altering) of Gene_expression (expression) of PPARG associated with inflammation and cancer
1) Confidence 0.50 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2585099 Disease Relevance 1.03 Pain Relevance 0.18
That specific regions of the PPARG promoter are differentially methylated points out that epigenetic mechanism(s) are involved in its deregulated expression in CRC cells.
Regulation (deregulated) of Gene_expression (expression) of PPARG associated with colon cancer
2) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.26 Pain Relevance 0
PPARG expression was assessed in CRC tissues and paired normal mucosa by western blot and immunohistochemistry and related to patients' clinicopathological parameters and survival.
Regulation (paired) of Gene_expression (expression) of PPARG associated with colon cancer
3) Confidence 0.45 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2997072 Disease Relevance 0.54 Pain Relevance 0
, confirming their crucial role in PPARG epigenetic repression.
Regulation (role) of Gene_expression (repression) of PPARG associated with repression
4) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.42 Pain Relevance 0
This is the first report that shows promoter methylation to play a role in PPARG repression in tumorigenesis.
Regulation (role) of Gene_expression (repression) of PPARG associated with repression
5) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 1.01 Pain Relevance 0
To investigate whether these HCT116 growth characteristics rely on PPARG expression, we stably silenced PPARG in HT29 cells.
Spec (whether) Regulation (rely) of Gene_expression (expression) of PPARG
6) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.63 Pain Relevance 0
Consistently, MeCP2 and EZH2 levels inversely correlate with PPARG expression in the CRC cells investigated.
Regulation (correlate) of Gene_expression (expression) of PPARG associated with colon cancer
7) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.65 Pain Relevance 0
Also, PPARgamma expression was selectively targeted by antisense oligonucleotide treatment.
Regulation (targeted) of Gene_expression (expression) of PPARgamma
8) Confidence 0.45 Published 2002 Journal Int. J. Cancer Section Abstract Doc Link 11948457 Disease Relevance 0.63 Pain Relevance 0.21
Another nonsense mutation in PPARG, namely A553?
Regulation (nonsense) of Gene_expression (mutation) of PPARG
9) Confidence 0.44 Published 2006 Journal BMC Med Genet Section Body Doc Link PMC1368963 Disease Relevance 0.29 Pain Relevance 0
Few studies have directly considered the real effect of PPARG variants on the PPARG expression itself and of its target genes, evaluating the alteration of its binding affinity to PPRE, the promoter efficiency, and other factors that may affect its transactivation ability [73–84].
Regulation (effect) of Gene_expression (expression) of PPARG
10) Confidence 0.43 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 0.14 Pain Relevance 0
Interestingly, stromal cells in the tumoral microenvironment can also differ from their normal counterparts in the expression of biologically meaningful molecules [29] including also COX2 and PPARG expression.
Regulation (differ) of Gene_expression (expression) of PPARG in stromal cells associated with cox2
11) Confidence 0.42 Published 2010 Journal PPAR Research Section Body Doc Link PMC2712952 Disease Relevance 0.90 Pain Relevance 0.30
Pooled estimate of CHD odds ratios were calculated from published studies for the PPARG Ala12Pro SNP including 6898 cases and 11?
Regulation (calculated) of Gene_expression (studies) of PPARG (A12P) associated with coronary artery disease
12) Confidence 0.39 Published 2009 Journal PPAR Research Section Body Doc Link PMC2792957 Disease Relevance 0.79 Pain Relevance 0
Exposure to 10 nM ouabain for two days did not significantly change PPARG or LPL expression (Fig. 5A), but a four-day exposure resulted in a 2.5-fold decrease in PPARG and 3.7-fold decrease in LPL expression (Fig. 5B, p<0.02) compared to untreated AD.
Neg (not) Regulation (change) of Gene_expression (expression) of PPARG
13) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2581599 Disease Relevance 0 Pain Relevance 0
In conclusion, we demonstrate that epigenetic events play a role in PPARG expression.
Regulation (play) of Gene_expression (expression) of PPARG
14) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.35 Pain Relevance 0.13
PPARG expression was synergistically induced by the combined treatment with AZA and TSA in HCT116 cells while was not affected in HT29 cells, when the drugs were used either alone or in combination (Figure S3).
Neg (not) Regulation (affected) of Gene_expression (expression) of PPARG
15) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.23 Pain Relevance 0
In conclusion, we demonstrate that epigenetic events play a role in PPARG expression.
Regulation (role) of Gene_expression (expression) of PPARG
16) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.35 Pain Relevance 0.13
The molecular mechanisms underlying PPARG expression regulation in CRC progression are still unknown [9].
Regulation (regulation) of Gene_expression (expression) of PPARG associated with colon cancer
17) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.49 Pain Relevance 0.04
To provide insights into the mechanism(s) by which DNA methylation and histone modifications affect PPARG expression, quantitative ChIP assays were performed investigating the promoter segment extending from ?
Regulation (affect) of Gene_expression (expression) of PPARG
18) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0 Pain Relevance 0.04
These nonfunctional association studies do not prove—allowing just to hypothesize—the altered expression of PPARG target genes.
Regulation (altered) of Gene_expression (expression) of PPARG
19) Confidence 0.26 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 0.55 Pain Relevance 0.04
The reduction of dopamine transporter (DAT)-positive signals and PPAR gamma expression, and accumulation of activated microglial cells were significantly and dose-dependently attenuated by four injections of a nonsteroidal anti-inflammatory drug and a PPAR gamma ligand, ibuprofen (10 or 20 mg/kg x 4, s.c.) given 30 min prior to each METH injection, but not by either a low or high dose of aspirin.
Regulation (attenuated) of Gene_expression (expression) of PPAR gamma in microglial cells associated with aspirin, dopamine, inflammation and cinod
20) Confidence 0.26 Published 2009 Journal Neurochem. Res. Section Abstract Doc Link 18946735 Disease Relevance 0.34 Pain Relevance 0.23

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