INT79693

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Context Info
Confidence 0.51
First Reported 1999
Last Reported 2010
Negated 6
Speculated 1
Reported most in Body
Documents 30
Total Number 31
Disease Relevance 21.96
Pain Relevance 8.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il4) extracellular region (Il4)
Anatomy Link Frequency
T cells 4
liver 3
macrophage 2
blood 1
poly 1
Il4 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 480 100.00 Very High Very High Very High
chemokine 59 100.00 Very High Very High Very High
cINOD 20 100.00 Very High Very High Very High
rheumatoid arthritis 162 99.96 Very High Very High Very High
acular 4 99.40 Very High Very High Very High
Inflammation 733 99.30 Very High Very High Very High
tolerance 37 99.24 Very High Very High Very High
fibrosis 283 98.94 Very High Very High Very High
Paracetamol 14 97.88 Very High Very High Very High
Arthritis 61 97.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Systemic Lupus Erythematosus 274 100.00 Very High Very High Very High
Adhesions 35 100.00 Very High Very High Very High
Rheumatoid Arthritis 174 99.96 Very High Very High Very High
Targeted Disruption 50 99.68 Very High Very High Very High
Liver Disease 10 99.56 Very High Very High Very High
Toxoplasmosis 9 99.36 Very High Very High Very High
INFLAMMATION 755 99.32 Very High Very High Very High
Fibrosis 209 99.16 Very High Very High Very High
Bacterial Meningitis 7 99.08 Very High Very High Very High
Pulmonary Fibrosis 215 98.94 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, liver homeostasis following AILD appears to be highly dependent on the activities of both IL-10 and IL-4, which together help prevent overexpression of IL-6 and other potential hepatotoxic factors.
Regulation (dependent) of IL-4 in liver associated with liver disease
1) Confidence 0.51 Published 2007 Journal Chem. Res. Toxicol. Section Abstract Doc Link 17305405 Disease Relevance 0.88 Pain Relevance 0.54
OBJECTIVE: To assess the effects of two macrophage down-regulating cytokines (interleukin [IL]-10 and IL-4) and the nonsteroidal anti-inflammatory drug ketorolac tromethamine on postoperative adhesion formation.
Regulation (effects) of IL-4 in macrophage associated with inflammation, acular, cinod, adhesions and cytokine
2) Confidence 0.43 Published 1999 Journal Fertil. Steril. Section Abstract Doc Link 9935118 Disease Relevance 0.27 Pain Relevance 0.32
Immunomodulation with interleukin-10 and interleukin-4 compared with ketorolac tromethamine for prevention of postoperative adhesions in a murine model.
Regulation (Immunomodulation) of interleukin-4 associated with acular and adhesions
3) Confidence 0.43 Published 1999 Journal Fertil. Steril. Section Title Doc Link 9935118 Disease Relevance 0.10 Pain Relevance 0.33
Genes promoting immune responses were down-regulated, including genes for the proinflammatory/Th2 cytokines IL-1b, IL-4, IL-6, IL-10, IL-13, and TNF-?.
Regulation (regulated) of IL-4 associated with cytokine
4) Confidence 0.43 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137099 Disease Relevance 1.03 Pain Relevance 0.51
Down-regulation of Th2 cytokine genes (Il4, Il10, Il13), as described in our data, has been reported in alloreactive T cells in which tolerance has been induced and immune rejection suppressed (Taylor et al. 2002).
Regulation (regulation) of Il4 in T cells associated with tolerance and cytokine
5) Confidence 0.43 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137099 Disease Relevance 1.02 Pain Relevance 0.54
Role of IL-6 in an IL-10 and IL-4 double knockout mouse model uniquely susceptible to acetaminophen-induced liver injury.
Regulation (Role) of IL-4 in liver associated with targeted disruption, paracetamol and injury
6) Confidence 0.38 Published 2007 Journal Chem. Res. Toxicol. Section Title Doc Link 17305405 Disease Relevance 0.61 Pain Relevance 0.65
The present study demonstrates the influence of endogenous IL-4 and IFN-gamma on blood pressure.
Regulation (influence) of IL-4 in blood
7) Confidence 0.27 Published 1999 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9920823 Disease Relevance 0.13 Pain Relevance 0.08
Animals treated with R-954 showed an increased anti-inflammatory cytokine profile, whereby GATA-3, IL-4 and IL-10 were up regulated while T-bet and IL-1?
Regulation (regulated) of IL-4 associated with inflammation and cytokine
8) Confidence 0.17 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 1.24 Pain Relevance 0.58
Effect of N-acetylcysteine administration on intraoperative plasma levels of interleukin-4 and interleukin-10 in liver transplant recipients.
Regulation (Effect) of interleukin-4 in liver
9) Confidence 0.14 Published 2008 Journal Transplant. Proc. Section Title Doc Link 19010165 Disease Relevance 0.09 Pain Relevance 0.14
Altogether, despite a clear cut influence on IL-4 levels, to what extent CERK may participate in TH2 cell biology remains elusive.
Regulation (influence) of IL-4
10) Confidence 0.12 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2817648 Disease Relevance 0.16 Pain Relevance 0.12
The concentrations of IL-4, IL-5, IL-10, and IL-13 (R & D system, Minneapolis, MN, USA) in the BALF were measured using enzyme-linked immunosorbent assay (ELISA) kits, according to the manufacturer's instructions.


Regulation (concentrations) of IL-4
11) Confidence 0.12 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2730622 Disease Relevance 0 Pain Relevance 0
The administration of either cilostazol (Group C) or sildenafil (Group E) alone did not alter IL-4 levels in BAL fluid.
Neg (not) Regulation (alter) of IL-4
12) Confidence 0.12 Published 2004 Journal Respir Res Section Body Doc Link PMC419478 Disease Relevance 0.12 Pain Relevance 0.14
[249-251].The Th2 cytokines of the other side of the adaptive response, IL-4 and IL-13, inhibit IL-12 induction in the early phases of stimulation, but later they can be potent inducers of IL-12 production, although they still inhibit many of the IFN-?
Regulation (response) of IL-4 associated with cytokine
13) Confidence 0.11 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.29 Pain Relevance 0.23
and IL-2 responses, and 19, 20, and 21 caused IL-10, IL-4 and IL-5 responses by HTLs isolated from Pneumococci-exposed mice.


Regulation (responses) of IL-4 associated with bacterial meningitis
14) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2828482 Disease Relevance 0.39 Pain Relevance 0.04
Earlier reports proposed a Th2 response (especially IL-4) (or a mixed Th1 and Th2 response) [1, 32–35] whereas recent evidences demonstrated the importance of the Th1 response especially IFN-?
Regulation (response) of IL-4
15) Confidence 0.08 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2933908 Disease Relevance 0.86 Pain Relevance 0.18
Because IL-4, IL-6, IL-13 and NRAMP are very important in immunity to toxoplasmosis and could play a pathogenic role in the inflammatory process we observed, mice without IL-4, IL-6, IL-13, or Nramp, infected for shorter times, were also studied to determine whether these cytokines or immune processes were necessary and sufficient for the perivascular cuffing and meningeal and parenchymal abnormalities we had observed.
Regulation (important) of IL-4 associated with inflammation, congenital anomalies, toxoplasmosis and cytokine
16) Confidence 0.08 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2588578 Disease Relevance 1.23 Pain Relevance 0.23
For example, pulmonary fibroblasts from IPF patients have spontaneously elevated levels of IL-13 and IL-4 receptor subunits, and it has been suggested that the abnormal proliferative properties of lung fibroblasts from certain lung fibrosis patient groups can be modulated in a manner that is dependent on the IL-4 and IL-13 receptor expression [10].
Regulation (dependent) of IL-4 in lung associated with fibrosis and pulmonary fibrosis
17) Confidence 0.08 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.88 Pain Relevance 0.44
, with no significant differences in IL-4 and IL-5 production [41].
Neg (no) Regulation (differences) of IL-4
18) Confidence 0.07 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2700264 Disease Relevance 1.00 Pain Relevance 0.12
No similar effect on the levels of IL-4, IL-13 or IFN-?
Neg (No) Regulation (effect) of IL-4
19) Confidence 0.05 Published 2005 Journal Respir Res Section Body Doc Link PMC1274346 Disease Relevance 1.57 Pain Relevance 0.34
No similar effect on the levels of IL-4, IL-13 or IFN-?
Neg (No) Regulation (effect) of IL-4
20) Confidence 0.05 Published 2005 Journal Respir Res Section Body Doc Link PMC1274346 Disease Relevance 0.96 Pain Relevance 0.39

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