INT797

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Context Info
Confidence 0.62
First Reported 1977
Last Reported 2010
Negated 163
Speculated 105
Reported most in Abstract
Documents 812
Total Number 917
Disease Relevance 111.13
Pain Relevance 542.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Penk)
Anatomy Link Frequency
brain 105
striatum 59
neurons 34
hippocampus 26
hypothalamus 24
Penk (Rattus norvegicus)
Penk - A2M (2) Penk - S2L (1)
Pain Link Frequency Relevance Heat
Enkephalin 4124 100.00 Very High Very High Very High
substance P 467 100.00 Very High Very High Very High
Opioid 451 100.00 Very High Very High Very High
Neuropeptide 419 100.00 Very High Very High Very High
Dynorphin 397 100.00 Very High Very High Very High
Dopamine 368 100.00 Very High Very High Very High
Morphine 322 100.00 Very High Very High Very High
Hippocampus 293 100.00 Very High Very High Very High
narcan 266 100.00 Very High Very High Very High
antagonist 263 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 185 100.00 Very High Very High Very High
Stress 173 100.00 Very High Very High Very High
Convulsion 161 100.00 Very High Very High Very High
Shock 68 100.00 Very High Very High Very High
Aids-related Complex 47 100.00 Very High Very High Very High
Parkinson's Disease 43 100.00 Very High Very High Very High
Cv Unclassified Under Development 41 100.00 Very High Very High Very High
Nociception 31 100.00 Very High Very High Very High
Generalized Anxiety Disorder 23 100.00 Very High Very High Very High
Disorders Of The Lacrimal System 15 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, SCH 58261 given alone did not influence the level of PENK mRNA in any examined part of the striatum.
Neg (not) Spec (examined) Regulation (influence) of PENK mRNA in striatum
1) Confidence 0.62 Published 2003 Journal Brain Res. Section Abstract Doc Link 12834887 Disease Relevance 0.55 Pain Relevance 0.40
Orchidectomy did not affect basal PENK mRNA levels in the PVN, but reduced PENK mRNA levels in the VMN.
Neg (not) Regulation (affect) of PENK mRNA in PVN
2) Confidence 0.62 Published 2002 Journal J. Psychopharmacol. (Oxford) Section Abstract Doc Link 12503826 Disease Relevance 0 Pain Relevance 0.12
These findings suggested that cardiac enkephalin metabolism is regulated by cardiac events.
Regulation (regulated) of enkephalin associated with enkephalin
3) Confidence 0.62 Published 2001 Journal Arch. Physiol. Biochem. Section Abstract Doc Link 11471067 Disease Relevance 0.81 Pain Relevance 0.87
The effect of ischemia on cardiac Leucine enkephalin (Leu-enk) content, degradation and coronary release was studied in the isolated perfused hearts of male Sprague Dawley rats.
Regulation (effect) of enkephalin in hearts associated with ischemia and enkephalin
4) Confidence 0.62 Published 2001 Journal Arch. Physiol. Biochem. Section Abstract Doc Link 11471067 Disease Relevance 0.32 Pain Relevance 0.40
We have recently determined that the level of ppEnk mRNA is developmentally and hormonally regulated in rat ventricular cardiac muscle tissue and in cultured myocytes (J.
Regulation (regulated) of ppEnk mRNA in cardiac muscle tissue
5) Confidence 0.62 Published 1992 Journal Am. J. Physiol. Section Abstract Doc Link 1279991 Disease Relevance 0 Pain Relevance 0.13
Regulation of pituitary and brain enkephalin systems by estrogen.
Regulation (Regulation) of enkephalin in brain associated with enkephalin
6) Confidence 0.62 Published 1982 Journal Life Sci. Section Title Doc Link 7162336 Disease Relevance 0 Pain Relevance 0.91
Rapid changes in enkephalin levels in rat striatum and hypothalamus induced by diazepam.
Regulation (changes) of enkephalin in striatum associated with enkephalin
7) Confidence 0.62 Published 1979 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 522892 Disease Relevance 0.06 Pain Relevance 0.76
Neither acute or chronic morphine treatment nor precipitated morphine withdrawal induced significant changes in enkephalin levels in any brain region.
Regulation (changes) of enkephalin in brain associated with enkephalin, withdrawal and morphine
8) Confidence 0.62 Published 1977 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 563989 Disease Relevance 0 Pain Relevance 1.00
In contrast, treatments that increased cGMP levels, the cyclic nucleotide associated with muscarinic receptor activation, had no effect on enkephalin content compared to control explants.
Neg (no) Regulation (effect) of enkephalin associated with enkephalin
9) Confidence 0.62 Published 1990 Journal Neuroscience Section Abstract Doc Link 2359494 Disease Relevance 0.19 Pain Relevance 0.94
The effect of dexamethasone on enkephalin-containing (EC) peptide levels and preproenkephalin mRNA levels was determined in adrenal medullary explants (glands) from sham and hypophysectomized (hypox) rats.
Regulation (effect) of preproenkephalin in glands associated with enkephalin and dexamethasone
10) Confidence 0.62 Published 1988 Journal Mol. Endocrinol. Section Abstract Doc Link 3412328 Disease Relevance 0 Pain Relevance 0.40
Chronic administration of cannabinoids regulates proenkephalin mRNA levels in selected regions of the rat brain.
Regulation (regulates) of proenkephalin in brain associated with cannabinoid and enkephalin
11) Confidence 0.62 Published 1998 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 9645967 Disease Relevance 0.14 Pain Relevance 0.54
Lithium and haloperidol differentially alter the dynorphin A (1-8) and enkephalin levels in the neurointermediate lobe of rat pituitary.
Regulation (alter) of enkephalin in lobe associated with dynorphin and enkephalin
12) Confidence 0.62 Published 1987 Journal Neuropeptides Section Title Doc Link 2891076 Disease Relevance 0 Pain Relevance 0.71
Taken together, these results indicate a sex difference in total preproenkephalin levels and in estrogenic regulation of preproenkephalin mRNA in the POA of juvenile rats.
Regulation (regulation) of preproenkephalin in juvenile
13) Confidence 0.62 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9748541 Disease Relevance 0.22 Pain Relevance 0.09
Elevation of circulating corticosterone levels in intact rats by 2-3 h of restraint stress, a multiple daily stress regimen over 1-21 days, or corticosterone injection did not change the level of preproenkephalin mRNA in the striatum; however, a single 16-h restraint stress resulted in a decreased level of expression.
Neg (not) Regulation (change) of preproenkephalin in striatum associated with stress
14) Confidence 0.62 Published 1990 Journal Endocrinology Section Abstract Doc Link 2351111 Disease Relevance 0.29 Pain Relevance 0
The results demonstrate that in the striatum the preproenkephalin mRNA is expressed at a high level and is regulated by glucocorticoids.
Regulation (regulated) of preproenkephalin in striatum
15) Confidence 0.62 Published 1990 Journal Endocrinology Section Abstract Doc Link 2351111 Disease Relevance 0.12 Pain Relevance 0
Sex differences in estrogenic regulation of preproenkephalin mRNA levels in the medial preoptic area of prepubertal rats.
Regulation (regulation) of preproenkephalin in medial associated with urological neuroanatomy and enkephalin
16) Confidence 0.62 Published 1998 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 9748541 Disease Relevance 0.25 Pain Relevance 0.20
Dynamic changes in the levels of striatal proenkephalin mRNA and large molecular weight enkephalin containing peptides following electroacupuncture.
Regulation (changes) of proenkephalin mRNA associated with enkephalin and electroacupuncture
17) Confidence 0.62 Published 1986 Journal NIDA Res. Monogr. Section Title Doc Link 3123956 Disease Relevance 0 Pain Relevance 0.92
In general, administration of methamphetamine and cocaine alters preprodynorphin and preproenkephalin mRNA levels in striatum.
Regulation (alters) of preproenkephalin in striatum associated with cocaine
18) Confidence 0.62 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 11032895 Disease Relevance 0 Pain Relevance 0.39
The goal of this study was to delineate the effects of dopamine antagonists on the regulation of preproenkephalin mRNA and opioid peptides in the rat brain.
Regulation (regulation) of preproenkephalin in brain associated with dopamine, antagonist and opioid
19) Confidence 0.62 Published 1990 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 2170802 Disease Relevance 0 Pain Relevance 0.33
Regulation of both preproenkephalin mRNA and its derived opioids by haloperidol--a method for measurement of peptides and mRNA in the same tissue extract.
Regulation (Regulation) of preproenkephalin associated with enkephalin and opioid
20) Confidence 0.62 Published 1990 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 2170802 Disease Relevance 0 Pain Relevance 0.92

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