INT79703

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Context Info
Confidence 0.76
First Reported 1998
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 46
Total Number 49
Disease Relevance 14.18
Pain Relevance 13.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Agtr1a) aging (Agtr1a) Golgi apparatus (Agtr1a)
plasma membrane (Agtr1a) cytoplasm (Agtr1a) signal transducer activity (Agtr1a)
Anatomy Link Frequency
brain 7
RVLM 4
carotid body 2
smooth muscle cells 2
heart 2
Agtr1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
B1 receptor 93 99.98 Very High Very High Very High
medulla 52 99.68 Very High Very High Very High
Rostral ventrolateral medulla 35 99.64 Very High Very High Very High
Kinase C 29 99.44 Very High Very High Very High
cva 20 99.20 Very High Very High Very High
Spinal cord 42 98.60 Very High Very High Very High
agonist 1495 98.24 Very High Very High Very High
Thalamus 28 97.48 Very High Very High Very High
Pyramidal cell 72 97.08 Very High Very High Very High
gABA 57 96.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypoxia 222 99.26 Very High Very High Very High
Cv General 3 Under Development 12 99.20 Very High Very High Very High
Chronic Renal Failure 111 99.06 Very High Very High Very High
Obesity 61 98.40 Very High Very High Very High
Hypertension 63 97.88 Very High Very High Very High
Disease 173 95.84 Very High Very High Very High
Endotoxemia 15 95.64 Very High Very High Very High
Middle Cerebral Artery Infarction 108 95.52 Very High Very High Very High
Apoptosis 44 95.12 Very High Very High Very High
Cardiovascular Disorder Under Development 13 94.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment with microinjection of a selective iNOS inhibitor, S-methylisothiourea (250 pmol) bilaterally into the RVLM significantly reversed the reduction in both synthesis and activity of AT1R.
Gene_expression (synthesis) of AT1R in RVLM associated with rostral ventrolateral medulla
1) Confidence 0.76 Published 2003 Journal Hypertension Section Abstract Doc Link 12810755 Disease Relevance 0.34 Pain Relevance 0.47
The current study evaluated the hypothesis that a downregulation of the molecular synthesis and functional expression of angiotensin subtype 1 receptor (AT1R) in the RVLM is consequential to this upregulated iNOS.
Gene_expression (expression) of AT1R in RVLM associated with rostral ventrolateral medulla
2) Confidence 0.76 Published 2003 Journal Hypertension Section Abstract Doc Link 12810755 Disease Relevance 0.41 Pain Relevance 0.37
We conclude that a downregulation of molecular synthesis and functional expression of AT1R in the ventrolateral medulla is consequential to the overproduction of NO through upregulation of iNOS in the RVLM and may underlie the cardiovascular depression that takes place during experimental endotoxemia.
Gene_expression (expression) of AT1R in medulla associated with medulla, endotoxemia, rostral ventrolateral medulla, depression and cardiovascular disorder under development
3) Confidence 0.76 Published 2003 Journal Hypertension Section Abstract Doc Link 12810755 Disease Relevance 0.51 Pain Relevance 0.47
The current study evaluated the hypothesis that a downregulation of the molecular synthesis and functional expression of angiotensin subtype 1 receptor (AT1R) in the RVLM is consequential to this upregulated iNOS.
Gene_expression (expression) of angiotensin subtype 1 receptor in RVLM associated with rostral ventrolateral medulla
4) Confidence 0.76 Published 2003 Journal Hypertension Section Abstract Doc Link 12810755 Disease Relevance 0.41 Pain Relevance 0.37
Angiotensin type 1 (AT1) receptor expression was assessed by Western blot analysis and RT-PCR.
Gene_expression (expression) of AT1
5) Confidence 0.75 Published 2006 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 16469840 Disease Relevance 0.70 Pain Relevance 0.09
This was followed by a significant downregulation of both mRNA and protein levels of AT1R in the ventrolateral medulla, alongside reduced efficacy of angiotensin II (50 pmol) to induce an increase in systemic arterial pressure, heart rate, or sympathetic vasomotor outflow on unilateral microinjection into the RVLM.
Gene_expression (levels) of AT1R in heart associated with medulla and rostral ventrolateral medulla
6) Confidence 0.59 Published 2003 Journal Hypertension Section Abstract Doc Link 12810755 Disease Relevance 0.40 Pain Relevance 0.47
This may enhance the excitatory effect of Ang II on the carotid chemoreceptor mediated by the AT1 receptors that are also expressed in the glomus cells.
Gene_expression (expressed) of AT1 in glomus
7) Confidence 0.48 Published 2007 Journal The open cardiovascular medicine journal Section Body Doc Link PMC2570565 Disease Relevance 0.35 Pain Relevance 0.07
PCR was performed with primers selective for AT1 receptor, p47phox, and gp91phox (Table 1).
Gene_expression (selective) of AT1 receptor
8) Confidence 0.44 Published 2010 Journal International Journal of Hypertension Section Body Doc Link PMC3022169 Disease Relevance 0 Pain Relevance 0
In the present study, we found a reduction in the mRNA AT1 expression in the brainstem tissue in CRF rats accompanied by a significant increase in the level of p47phox and gp91phox gene expression in the RVLM compared to C group.
Gene_expression (expression) of AT1 in brainstem associated with medulla and chronic renal failure
9) Confidence 0.39 Published 2010 Journal International Journal of Hypertension Section Body Doc Link PMC3022169 Disease Relevance 0.76 Pain Relevance 0.38
Considering that in CRF there is an increase in the brain Ang II, the expression of AT1 subtype receptor was also quantified in the RVLM.
Gene_expression (expression) of AT1 in brain associated with chronic renal failure
10) Confidence 0.39 Published 2010 Journal International Journal of Hypertension Section Body Doc Link PMC3022169 Disease Relevance 0.87 Pain Relevance 0.08
Hence, the locally produced angiotensin II (Ang II) could act via paracrine or autocrine on the angiotensin AT1 receptors expressed in the carotid body [8, 9].
Gene_expression (expressed) of AT1 in carotid body
11) Confidence 0.37 Published 2007 Journal The open cardiovascular medicine journal Section Body Doc Link PMC2570565 Disease Relevance 0.43 Pain Relevance 0.12
Blockade of this event with a MEK1 inhibitor as late as 6 h after the insult reduced the enhanced vascular receptor expression and the associated cerebral infarction.



Gene_expression (expression) of vascular receptor associated with cva
12) Confidence 0.24 Published 2008 Journal BMC Neurosci Section Abstract Doc Link PMC2553085 Disease Relevance 0.36 Pain Relevance 0.09
Our observations are in agreement with the diminished activity of the downstream MAPK MEK/ERK pathway and its transcription factor Elk-1, as well as the reduced expression of specific vascular receptor proteins both in large cerebral vessels and in microvessels.
Gene_expression (expression) of vascular receptor in vessels
13) Confidence 0.24 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2553085 Disease Relevance 0.47 Pain Relevance 0.09
Double immunostaining for endothelin ETB, angiotensin AT1, and 5-hydroxytryptamine 5-HT1B receptors versus smooth muscle actin, expressed in the smooth muscle cells, revealed clear co-localization.
Gene_expression (expressed) of AT1 in smooth muscle cells
14) Confidence 0.24 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2553085 Disease Relevance 0.23 Pain Relevance 0
We observed for the first time a significant increase in the expression of endothelin ETB, angiotensin AT1, and 5-hydroxytryptamine 5-HT1B receptors in smooth muscle cells not only in the ischemic MCA but also in smooth muscle cells of cerebral microvessels associated with the ischemic region (Fig. 6 and 7).
Gene_expression (expression) of AT1 in smooth muscle cells
15) Confidence 0.24 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2553085 Disease Relevance 0.28 Pain Relevance 0
Hypoxia has been shown to strongly induce the expression of AT1b but not AT1a.
Gene_expression (expression) of AT1a associated with hypoxia
16) Confidence 0.15 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.03 Pain Relevance 0.04
Gene expression for AT1 and AT2 receptors has been identified in several ocular tissues, including the retina (Brandt et al 1994; Murata et al 1997; Wheeler-Schilling et al 1999; Sarlos et al 2003).
Gene_expression (expression) of AT1 in retina
17) Confidence 0.12 Published 2007 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2701139 Disease Relevance 0.26 Pain Relevance 0
Hypoxia has been demonstrated to induce the expression of both AT1b (AT1a and AT1b are subsets of AT1) and AT2 receptors in the rat carotid body and pancreas [39,40].
Gene_expression (expression) of AT1a in pancreas associated with hypoxia
18) Confidence 0.12 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.12 Pain Relevance 0.05
Defolliculated Xenopus oocytes expressing recombinant m1 or m3 muscarinic or (for comparison) AT1A angiotensin II receptors were voltage clamped, and Ca(2+)-activated Cl- currents (ICl(Ca)) induced by acetyl-beta-methylcholine (Mch) or angiotensin II were measured in the presence of clinically relevant concentrations of halothane, sevoflurane, desflurane or isoflurane.
Gene_expression (expressing) of AT1A in oocytes associated with isoflurane and halothane
19) Confidence 0.10 Published 1998 Journal Br J Anaesth Section Abstract Doc Link 9924234 Disease Relevance 0.16 Pain Relevance 0.26
For example, we found that angiotensin II is much more effective in releasing GH in pituitary aggregate cell cultures from hypertensive and prehypertensive spontaneously hypertensive rats (SHR) than in cultures from normal littermates (342) and, recently, it has been reported that, whereas normal rat anterior pituitary expresses the angiotensin AT1B-R, the SHR down-regulates AT1B-R and induces expression of the AT1A-R (343).
Gene_expression (expression) of AT1A-R in anterior pituitary associated with hypertension
20) Confidence 0.09 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.25 Pain Relevance 0

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