INT7971

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Context Info
Confidence 0.58
First Reported 1987
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 12
Total Number 13
Disease Relevance 1.72
Pain Relevance 2.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GNRH1) extracellular space (GNRH1) extracellular region (GNRH1)
cell-cell signaling (GNRH1)
Anatomy Link Frequency
pituitary 6
follicle 4
developmental stages 2
GNRH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 33 100.00 Very High Very High Very High
antagonist 5 100.00 Very High Very High Very High
endometriosis 5 98.84 Very High Very High Very High
Central nervous system 3 98.52 Very High Very High Very High
Neurotransmitter 5 98.46 Very High Very High Very High
Cholecystokinin 2 92.80 High High
Endogenous opioid 2 91.44 High High
Pain score 1 87.52 High High
Glutamate 4 82.36 Quite High
gABA 4 81.80 Quite High
Disease Link Frequency Relevance Heat
Breast Cancer 28 99.12 Very High Very High Very High
Endometriosis (extended) 16 98.84 Very High Very High Very High
Aging 44 87.92 High High
Pain 7 87.52 High High
Reprotox - General 3 7 86.08 High High
Reprotox - General 1 42 82.96 Quite High
Stress 1 80.08 Quite High
Cancer 13 70.36 Quite High
Syndrome 9 69.20 Quite High
Reprotox - General 2 77 68.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Through a feedback mechanism, they influence the synthesis and release of hypothalamic gonadotropin-releasing hormone (GnRH) and/or pituitary gonadotropic hormones (luteinizing hormone, LH, and follicle stimulating hormone, FSH).
Regulation (influence) of Gene_expression (synthesis) of gonadotropin-releasing hormone in follicle
1) Confidence 0.58 Published 1992 Journal Psychoneuroendocrinology Section Abstract Doc Link 1359605 Disease Relevance 0 Pain Relevance 0.20
Clinical effects of luteinizing hormone-releasing hormone agonists
Regulation (effects) of Gene_expression (agonists) of luteinizing hormone-releasing hormone associated with agonist
2) Confidence 0.45 Published 2000 Journal Breast Cancer Res Section Body Doc Link PMC138786 Disease Relevance 0.51 Pain Relevance 0.26
[Indications for GnRH analogs in the treatment of genital endometriosis].
Regulation ([Indications) of Gene_expression (analogs) of GnRH associated with endometriosis
3) Confidence 0.45 Published 2007 Journal Gynecol Obstet Fertil Section Title Doc Link 17682231 Disease Relevance 0.50 Pain Relevance 0.34
Through a feedback mechanism, they influence the synthesis and release of hypothalamic gonadotropin-releasing hormone (GnRH) and/or pituitary gonadotropic hormones (luteinizing hormone, LH, and follicle stimulating hormone, FSH).
Regulation (influence) of Gene_expression (synthesis) of GnRH in follicle
4) Confidence 0.43 Published 1992 Journal Psychoneuroendocrinology Section Abstract Doc Link 1359605 Disease Relevance 0 Pain Relevance 0.20
Together, these data indicate developmentally regulated release and interactions of neurotransmitters (known regulators of GnRH-1 cells in adults) and point to extrinsic factors regulating GnRH-1 cellular physiology.
Regulation (regulating) of Gene_expression (physiology) of GnRH-1 associated with neurotransmitter
5) Confidence 0.39 Published 2010 Journal Endocrinology Section Abstract Doc Link 20555030 Disease Relevance 0 Pain Relevance 0.48
The goal of this study was to address whether these changes depend on the maturation status of GnRH-1 neurons by assaying prenatal GnRH-1 cells maintained in explants, at two different developmental stages.
Spec (whether) Regulation (depend) of Gene_expression (neurons) of GnRH-1 in developmental stages
6) Confidence 0.39 Published 2010 Journal Endocrinology Section Abstract Doc Link 20555030 Disease Relevance 0 Pain Relevance 0.33
It therefore seems likely that there are changes in endogenous production of GnRH which underlie the changes in LH secretion and have a role in the age related decline in testosterone.
Regulation (changes) of Gene_expression (production) of GnRH
7) Confidence 0.38 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2544367 Disease Relevance 0.35 Pain Relevance 0
Meta-analyses of RCTs where GnRH antagonists (rather than GnRH agonist) were used for pituitary suppression also failed to find any significant differences in terms of clinical pregnancy rates, as none of the studies included reported live birth.79
Regulation (used) of Gene_expression (antagonists) of GnRH in pituitary associated with antagonist and agonist
8) Confidence 0.32 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819896 Disease Relevance 0.14 Pain Relevance 0.20
These assessments would include the use of recombinant DNA technology to probe cellular regulation of GnRH production. 2.
Regulation (regulation) of Gene_expression (production) of GnRH
9) Confidence 0.30 Published 1987 Journal J Adolesc Health Care Section Abstract Doc Link 3319980 Disease Relevance 0.08 Pain Relevance 0.17
Endotoxin could alter circulating concentrations of LH via actions at the hypothalamus through altered GnRH production and/or release, or endotoxin could alter circulating concentrations of LH at the level of the pituitary via inhibition of LH production and release or inhibition of LH in response to GnRH.
Regulation (altered) of Gene_expression (production) of GnRH in pituitary
10) Confidence 0.21 Published 2003 Journal Domest. Anim. Endocrinol. Section Abstract Doc Link 12963096 Disease Relevance 0.07 Pain Relevance 0.13
Endotoxin could alter circulating concentrations of LH via actions at the hypothalamus through altered GnRH production and/or release, or endotoxin could alter circulating concentrations of LH at the level of the pituitary via inhibition of LH production and release or inhibition of LH in response to GnRH.
Regulation (alter) of Gene_expression (production) of GnRH in pituitary
11) Confidence 0.21 Published 2003 Journal Domest. Anim. Endocrinol. Section Abstract Doc Link 12963096 Disease Relevance 0.07 Pain Relevance 0.13
In the cichlid fish, Haplochromis burtoni, the expression of Gonadotropin-Releasing Hormone 1 (GnRH1) is socially regulated.
Regulation (regulated) of Gene_expression (expression) of GnRH1
12) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702002 Disease Relevance 0 Pain Relevance 0
Dynamic changes in the expression of GnRH1 influence a switch from aggressive to submissive behaviors as a result of social cues [10]; some individuals are more likely to exhibit aggressive/dominance behaviors in response to those social cues than others.
Regulation (changes) of Gene_expression (expression) of GnRH1
13) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702002 Disease Relevance 0 Pain Relevance 0

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