INT79711

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Context Info
Confidence 0.27
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 3.77
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
tails 2
M-1 1
M1 (Homo sapiens)
Pain Link Frequency Relevance Heat
primary somatosensory cortex 102 99.86 Very High Very High Very High
halothane 3 83.52 Quite High
Central nervous system 139 77.20 Quite High
isoflurane 3 76.76 Quite High
antagonist 16 76.32 Quite High
Peripheral nervous system 2 59.16 Quite High
Transcranial magnetic stimulation 25 50.00 Quite Low
tramadol 4 50.00 Quite Low
Dorsal horn 4 47.92 Quite Low
Pain 4 26.32 Quite Low
Disease Link Frequency Relevance Heat
Neuromyelitis Optica 524 99.08 Very High Very High Very High
Influenza Virus Infection 441 97.72 Very High Very High Very High
Disease 157 89.92 High High
Communicable Diseases 5 87.52 High High
Radiation Sickness 1 86.52 High High
Cancer 9 83.44 Quite High
Malignant Neoplastic Disease 1 83.08 Quite High
Vomiting 17 81.16 Quite High
Infection 68 75.28 Quite High
Vertigo 23 74.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
METHODS: With and without paroxetine pretreatment (20 mg daily for 3 consecutive days), the formation of M1 and the analgesic effect of 150 mg of tramadol were studied in 16 healthy extensive metabolizers of sparteine in a randomized, double-blind, placebo-controlled, 4-way crossover study by use of experimental pain models.
M1 Binding (formation) of
1) Confidence 0.27 Published 2005 Journal Clin. Pharmacol. Ther. Section Body Doc Link 15903129 Disease Relevance 0 Pain Relevance 0
Inhibitory function of the M1 as tested by the evoked cortical SP was found to be significantly different between groups.
M1 Binding (function) of
2) Confidence 0.20 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1513595 Disease Relevance 0 Pain Relevance 0
Surprisingly, the phase delays for the somatosensory areas were actually shorter than M1 for both 1DI (area 3a: 33.0?
M1 Binding (shorter) of
3) Confidence 0.12 Published 2010 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2927302 Disease Relevance 0 Pain Relevance 0.08
Alternatively, oscillations from S1 could propagate to M1, and thence to the periphery (Figure 7, Pathway 2).
M1 Binding (propagate) of associated with primary somatosensory cortex
4) Confidence 0.12 Published 2010 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2927302 Disease Relevance 0 Pain Relevance 0.26
The M1 protein lines the viral envelope in close proximity to the RNP and is hypothesized to interact with the cytoplasmic tails of the surface glycoproteins (Lamb and Krug 1996).
M1 Binding (interact) of in tails
5) Confidence 0.08 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695195 Disease Relevance 0.62 Pain Relevance 0
The M1 protein further interacts with cellular proteins and is involved in determining both the virion shape and size, as well as being involved in the viral budding process (Lamb and Krug 1996; Hui et al 2003).
M1 Binding (interacts) of
6) Confidence 0.08 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695195 Disease Relevance 0.35 Pain Relevance 0
M1 and RNPs interact with the cytoplasmic tails of HA and NA at the cell membrane.
M1 Binding (interact) of in tails
7) Confidence 0.07 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695195 Disease Relevance 0.32 Pain Relevance 0
Absence of interference with AT1A signalling and intracellular pathways suggest that the effects of anaesthetics on muscarinic signalling most likely result from interactions with the m1 or m3 receptor molecule.
m1 Binding (interactions) of
8) Confidence 0.06 Published 1998 Journal Br J Anaesth Section Abstract Doc Link 9924234 Disease Relevance 0 Pain Relevance 0.14
M-1 and M-23 AQP4-IgG binding results in different staining patterns
M-1 Binding (binding) of in M-1
9) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864757 Disease Relevance 0.25 Pain Relevance 0
Although the mechanism of action of diphenidol on the vestibular system has not yet been elucidated, it exerts an anticholinergic effect due to interactions with mACh receptors, particularly m1, m2, m3 and m4 [155].
m1 Binding (interactions) of
10) Confidence 0.03 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2866460 Disease Relevance 0.94 Pain Relevance 0.07
The influence on the architecture of AQP4 complexes by M23 and other protein elements needs to be understood before the role of anti-AQP4 antibody-mediated internalization of M1 AQP4 can be linked to NMO pathogenesis [30,35,36].
M1 Binding (internalization) of associated with neuromyelitis optica
11) Confidence 0.03 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 0.37 Pain Relevance 0.04
Pooled sera from the AQP4-peptide immunized mice bind the M1 human isoform and the rat M23 isoform of AQP4 in HEK cells.
M1 Binding (bind) of
12) Confidence 0.03 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 0.92 Pain Relevance 0

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