INT7972

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Context Info
Confidence 0.42
First Reported 1992
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 15
Total Number 17
Disease Relevance 5.73
Pain Relevance 1.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein modification process (PLOD1) endoplasmic reticulum (PLOD1)
Anatomy Link Frequency
pituitary 8
follicle 4
superior 2
granulosa cell 2
ovaries 2
PLOD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 19 100.00 Very High Very High Very High
narcan 4 99.68 Very High Very High Very High
antagonist 78 99.50 Very High Very High Very High
Dismenorea 3 99.28 Very High Very High Very High
agonist 108 99.14 Very High Very High Very High
withdrawal 36 97.94 Very High Very High Very High
Endogenous opioid 1 74.56 Quite High
Pain 17 71.68 Quite High
Central nervous system 1 64.60 Quite High
Dopamine 2 61.84 Quite High
Disease Link Frequency Relevance Heat
Endometriosis (extended) 156 100.00 Very High Very High Very High
Dysmenorrhea 2 99.28 Very High Very High Very High
Breast Cancer 9 99.04 Very High Very High Very High
Adenoma 6 98.54 Very High Very High Very High
Prostate Cancer 76 96.98 Very High Very High Very High
Immunotherapy Of Cancer 3 94.56 High High
Endocrine Disease 2 93.96 High High
Aging 96 93.44 High High
Malignant Neoplastic Disease 12 91.76 High High
Hypersensitivity 10 91.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In fertile women, naloxone administration increases LH levels in the luteal phase but not in the follicular phase.
Positive_regulation (increases) of Gene_expression (levels) of LH associated with narcan
1) Confidence 0.42 Published 1992 Journal Psychoneuroendocrinology Section Abstract Doc Link 1359605 Disease Relevance 0 Pain Relevance 0.29
In addition, the expression of LH/hCG-R has been demonstrated in endometriosis and has been shown to be increased in patients with adenomyosis [33–35].
Positive_regulation (increased) of Gene_expression (expression) of LH associated with endometriosis and dismenorea
2) Confidence 0.41 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913851 Disease Relevance 0.74 Pain Relevance 0.15
Mukherjee et al. [13] suggested that an elevated day 3 FSH: LH ratio >3.6, in the presence of a normal day 3 FSH is predictive of a poor response to ovarian stimulation.
Positive_regulation (response) of Gene_expression (predictive) of LH
3) Confidence 0.40 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1947995 Disease Relevance 0.14 Pain Relevance 0.14
However when we sub grouped our study population by serum LH levels similar to the above studies a statistical difference was found in cycles with basal serum LH ?
Positive_regulation (grouped) of Gene_expression (levels) of serum LH
4) Confidence 0.35 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1947995 Disease Relevance 0.06 Pain Relevance 0.07
Although some clinicians have reported that rLH administration prior to rFSH in IVF cycles increased the number of antral follicles, this did not translate into improved rates of live birth pregnancy.109 Thus, there is no evidence at the present time that co-administration of rLH to rFSH, in controlled ovarian hyperstimulation for IVF, has a beneficial effect in IVF.
Positive_regulation (increased) of Gene_expression (administration) of rLH in follicles
5) Confidence 0.31 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819896 Disease Relevance 0.20 Pain Relevance 0.18
Also in this case, the highest expression of the LH/hCG-R occurred during the luteal phase of the cycle, and paralleled an increased synthesis of PGE2.
Positive_regulation (occurred) of Gene_expression (expression) of LH
6) Confidence 0.30 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913851 Disease Relevance 0.05 Pain Relevance 0
This case is remarkable because the ovarian hyperstimulation related to the FSH-secreting adenoma was not associated with high levels of serum estradiol, probably due to insufficient LH production by the normal pituitary.
Positive_regulation (insufficient) of Gene_expression (production) of LH in pituitary associated with adenoma
7) Confidence 0.22 Published 2001 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 11502789 Disease Relevance 0.58 Pain Relevance 0.06
For example, StAR expression exhibited a similar pattern following either withdrawal/replacement regimen (Fig. 5), strongly suggesting that the changes evoked by LH were indirect and are due to LH-stimulated P production by the tissue.
Positive_regulation (due) of Gene_expression (production) of LH-stimulated associated with withdrawal
8) Confidence 0.15 Published 2009 Journal Molecular Human Reproduction Section Body Doc Link PMC2647108 Disease Relevance 0.12 Pain Relevance 0.27
Levels of both FSH and LH rise steadily during the period of follicle depletion during the peri-menopausal period, but the detailed dynamics involved are incompletely understood.
Positive_regulation (rise) of Gene_expression (Levels) of LH in follicle associated with endometriosis (extended)
9) Confidence 0.14 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2764709 Disease Relevance 0.54 Pain Relevance 0
There are changes in the lutenising hormone (LH) production which consist of decreased LH pulse frequency and amplitude, (Veldhuis et al 1992; Pincus et al 1997) although pituitary production of LH in response to pharmacological stimulation with exogenous GnRH analogues is preserved (Mulligan et al 1999).
Positive_regulation (response) of Gene_expression (production) of LH in pituitary
10) Confidence 0.13 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2544367 Disease Relevance 0.42 Pain Relevance 0
This classic model has since been revised to take account of the induction of granulosa cell LH receptor expression by FSH during advanced stages of antral follicular development [15,103-105].
Positive_regulation (induction) of Gene_expression (expression) of LH in granulosa cell
11) Confidence 0.13 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2764709 Disease Relevance 0.06 Pain Relevance 0.11
GnRH receptor antagonists (blockers) are a new class of endocrine therapy that bind directly to the GnRH receptor, rapidly blocking the release of both LH and FSH, and thereby reducing testosterone secretion (Figure 1).20–25 In contrast to the agonists, GnRH antagonists do not cause an initial stimulation of LH production, and therefore do not cause testosterone surge or clinical flare.12 Abarelix was the first GnRH antagonist to be licensed for prostate cancer treatment; however, this agent was associated with immediate-onset systemic allergic reactions resulting from histamine release, and so is currently marketed only in Germany.26
Positive_regulation (stimulation) of Gene_expression (production) of LH associated with antagonist, hypersensitivity, agonist and immunotherapy of cancer
12) Confidence 0.11 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004563 Disease Relevance 0.73 Pain Relevance 0.41
Degarelix is a new GnRH receptor blocker that has recently been approved for the treatment of men with advanced, hormone-sensitive prostate cancer.27 It acts by immediate and competitive blockade of GnRH receptors in the pituitary; like other GnRH antagonists, degarelix does not cause an initial stimulation of LH production via the HPG axis, and therefore does not cause testosterone surge or clinical flare.12

Pharmacology and pharmacokinetics of degarelix

Positive_regulation (stimulation) of Gene_expression (production) of LH in pituitary associated with antagonist and prostate cancer
13) Confidence 0.11 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004563 Disease Relevance 0.32 Pain Relevance 0.25
Since it was shown in the late 1980s that too high a concentration of LH might have a negative effect on fertilization and embryo quality, the idea arose that pure FSH preparations might be superior to hMG preparations for patients with endogenous LH production [316].
Spec (might) Positive_regulation (superior) of Gene_expression (production) of LH in superior
14) Confidence 0.10 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0.13 Pain Relevance 0.03
Increased Luteinizing Hormone (LH) levels, compared to the FSH, result in increased androgen production in the ovaries.
Positive_regulation (Increased) of Gene_expression (levels) of LH in ovaries
15) Confidence 0.06 Published 2010 Journal International Journal of Trichology Section Body Doc Link PMC3002408 Disease Relevance 1.28 Pain Relevance 0
GnRH seems to be a more physiologic agent for increasing the pituitary’s production of FSH and LH, especially when it is administered in a pulsatile fashion in programmable, portable minipumps.
Positive_regulation (increasing) of Gene_expression (production) of LH in pituitary
16) Confidence 0.06 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721319 Disease Relevance 0.35 Pain Relevance 0
After 24 hours of incubation in DMEM/LH, IL-1?
Positive_regulation (incubation) of Gene_expression (/) of LH
17) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0 Pain Relevance 0

General Comments

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