INT79720

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Context Info
Confidence 0.70
First Reported 1998
Last Reported 2010
Negated 5
Speculated 2
Reported most in Abstract
Documents 57
Total Number 60
Disease Relevance 31.81
Pain Relevance 10.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cat) mitochondrion (Cat) oxidoreductase activity (Cat)
Golgi apparatus (Cat) endoplasmic reticulum (Cat) plasma membrane (Cat)
Anatomy Link Frequency
liver 5
brain 4
heart 3
kidney 2
body 2
Cat (Mus musculus)
Pain Link Frequency Relevance Heat
fluoxetine 6 99.84 Very High Very High Very High
ischemia 46 99.20 Very High Very High Very High
Paracetamol 54 98.96 Very High Very High Very High
Eae 21 98.28 Very High Very High Very High
fibrosis 131 98.16 Very High Very High Very High
Inflammation 624 97.80 Very High Very High Very High
analgesia 7 96.96 Very High Very High Very High
Enkephalin 5 96.00 Very High Very High Very High
depression 22 94.56 High High
Analgesic 20 94.44 High High
Disease Link Frequency Relevance Heat
Stress 1141 100.00 Very High Very High Very High
Colitis 84 100.00 Very High Very High Very High
Tumor Necrosis Factor Receptor-associated Periodic Syndrome 2 99.96 Very High Very High Very High
Sprains And Strains 108 99.82 Very High Very High Very High
Pressure And Volume Under Development 71 99.82 Very High Very High Very High
Body Weight 112 99.60 Very High Very High Very High
Diabetes Mellitus 108 99.36 Very High Very High Very High
Hepatotoxicity 41 99.26 Very High Very High Very High
Cv Unclassified Under Development 43 99.20 Very High Very High Very High
Nicotine Addiction 70 98.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Protection against acetaminophen hepatotoxicity by clofibrate pretreatment: role of catalase induction.
Positive_regulation (induction) of catalase associated with paracetamol and hepatotoxicity
1) Confidence 0.70 Published 2002 Journal J. Biochem. Mol. Toxicol. Section Title Doc Link 12439864 Disease Relevance 0.25 Pain Relevance 0.62
In conclusion, these results indicate that elevated catalase activity in mice exposed to CFB does not appear to mediate the hepatoprotection, suggesting that other cellular defense mechanisms are involved.
Positive_regulation (elevated) of catalase
2) Confidence 0.70 Published 2002 Journal J. Biochem. Mol. Toxicol. Section Abstract Doc Link 12439864 Disease Relevance 0.22 Pain Relevance 0.61
Similar to fibrosis, the decrease in catalase at the levels of activity and mRNA expression was also temporal; catalase levels appeared to increase again at 21 days (Figure 3) and tended to become restored at 35 days before the resolution phase (data not shown).
Positive_regulation (increase) of catalase associated with fibrosis
3) Confidence 0.69 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 1.20 Pain Relevance 0.45
The anti-inflammatory mechanisms of ST1 might be related to the decrease in the level of MDA, iNOS, and COX-2 in the edema paw via increasing the activities of CAT, SOD, and GPx in the liver through the suppression of TNF-alpha and NO.
Positive_regulation (increasing) of CAT in liver associated with pressure and volume under development and inflammation
4) Confidence 0.67 Published 2010 Journal J. Agric. Food Chem. Section Abstract Doc Link 20507140 Disease Relevance 0.93 Pain Relevance 0.29
Increasing catalase activity seems to be necessary.
Positive_regulation (Increasing) of catalase
5) Confidence 0.62 Published 2007 Journal Microb Cell Fact Section Body Doc Link PMC1949835 Disease Relevance 0.91 Pain Relevance 0.28
Two hypotheses could explain this result: i) no induction of effective oxidative stress in our moderate colitis model and/or ii) a too low catalase activity delivered in digestive tractus via Lb. casei BL23 MnKat+.
Neg (no) Positive_regulation (induction) of catalase associated with colitis and stress
6) Confidence 0.62 Published 2007 Journal Microb Cell Fact Section Body Doc Link PMC1949835 Disease Relevance 0.98 Pain Relevance 0.22
Increasing catalase activity seems to be necessary.
Positive_regulation (necessary) of catalase
7) Confidence 0.62 Published 2007 Journal Microb Cell Fact Section Body Doc Link PMC1949835 Disease Relevance 0.96 Pain Relevance 0.28
Biochemical analysis revealed that chronic swim test significantly increased lipid peroxidation and catalase levels in whole brains of mice.
Positive_regulation (increased) of catalase in brains
8) Confidence 0.56 Published 2002 Journal Indian J. Exp. Biol. Section Abstract Doc Link 13677625 Disease Relevance 0.34 Pain Relevance 0.21
Biochemical analyses revealed an increase in malondialdehyde, nitrite level and depleted glutathione and catalase activity in stressed brain.
Positive_regulation (increase) of catalase in brain
9) Confidence 0.50 Published 2007 Journal Pharmacol Rep Section Abstract Doc Link 17652828 Disease Relevance 0.74 Pain Relevance 0.32
Animals were sacrificed 24 h after administration of final dose of the extract and NIM, liver tissues were collected, and the activities of SOD and CAT and levels of GSH and lipid peroxidation end-product (as MDA), were determined from the livers of all the experimental animals.
Spec (determined) Positive_regulation (determined) of CAT in livers
10) Confidence 0.49 Published 2006 Journal Indian J. Biochem. Biophys. Section Abstract Doc Link 17133737 Disease Relevance 0.20 Pain Relevance 0.14
Pretreatment with HSE decreased lipid peroxidation and increased catalase activity and glutathione level.
Positive_regulation (increased) of catalase
11) Confidence 0.48 Published 2010 Journal J. Sci. Food Agric. Section Body Doc Link 20355050 Disease Relevance 0.09 Pain Relevance 0
Among the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST) levels were restored to almost normal levels compared with the control group.
Positive_regulation (restored) of catalase
12) Confidence 0.47 Published 2006 Journal Phytother Res Section Abstract Doc Link 16718736 Disease Relevance 0.32 Pain Relevance 0.44
Biochemically, quercetin treatment attenuated malondialdehyde accumulation and nitrite activity and restored the depleted reduced glutathione and catalase activity.
Positive_regulation (restored) of catalase
13) Confidence 0.47 Published 2008 Journal J Med Food Section Abstract Doc Link 18800893 Disease Relevance 0.53 Pain Relevance 0.25
Biochemically, alprazolam pretreatment decreased malondialdehyde, nitrite activity and restored reduced glutathione level and catalase activity.
Positive_regulation (restored) of catalase
14) Confidence 0.47 Published 2007 Journal Pharmacol Rep Section Abstract Doc Link 17652828 Disease Relevance 0.66 Pain Relevance 0.31
The objective of the present study was to investigate whether the increase in hepatic catalase activity following CFB pretreatment plays a role in this hepatoprotection.
Spec (whether) Positive_regulation (increase) of catalase
15) Confidence 0.47 Published 2002 Journal J. Biochem. Mol. Toxicol. Section Abstract Doc Link 12439864 Disease Relevance 0.17 Pain Relevance 0.45
The catalase activity of saline-perfused lungs was not statistically different from unperfused lungs (252.0 ± 21.4 nmol/min/mg protein vs. 189.7 ± 27.7, NS), suggesting that catalase activity in lung homogenates is not due to circulating erythrocytes, but rather originates from lung structural cells.


Neg (not) Positive_regulation (due) of catalase in lung
16) Confidence 0.46 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.50 Pain Relevance 0.12
John's Wort treatment significantly attenuated lipid peroxidation, nitrite concentration and partially restored GSH and catalase activity suggesting its antioxidant like effect.
Positive_regulation (restored) of catalase
17) Confidence 0.45 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2882899 Disease Relevance 0.46 Pain Relevance 0.62
6-hr acute restraint stress significantly increased malondialdehyde, nitrite concentration, depleted reduced glutathione and catalase activity as compared to unstressed (naïve) animals (Table 2).
Positive_regulation (increased) of catalase associated with stress
18) Confidence 0.45 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2882899 Disease Relevance 0.70 Pain Relevance 0.32
The decreased level of tissue enzymes, i.e., superoxide dismutase (SOD), catalase (CAT) and increased level of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and acid phosphatase (ACP) were observed in mice treated with lead.
Positive_regulation (increased) of CAT
19) Confidence 0.45 Published 2010 Journal Toxicology International Section Abstract Doc Link PMC2964743 Disease Relevance 0.51 Pain Relevance 0
Administration of aqueous stem extract (400 mg/kg body weight, orally) and aqueous leaves extract (400 mg/kg body weight, orally) along with the lead nitrate (5 mg/kg body weight, i.p. for 30 days) increased the activities of SOD and CAT and decreased the levels of AST, ALT, ALP, and ACP enzymes in mice.
Positive_regulation (increased) of CAT in body associated with body weight
20) Confidence 0.45 Published 2010 Journal Toxicology International Section Abstract Doc Link PMC2964743 Disease Relevance 0.52 Pain Relevance 0

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