INT79721

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Context Info
Confidence 0.69
First Reported 1998
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 13
Total Number 15
Disease Relevance 10.69
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Hspa1a) response to stress (Hspa1a) cytoplasm (Hspa1a)
Anatomy Link Frequency
myocardium 2
fat 2
brain 2
hearts 2
body 2
Hspa1a (Mus musculus)
Pain Link Frequency Relevance Heat
Angina 3 98.80 Very High Very High Very High
ischemia 13 97.12 Very High Very High Very High
Inflammation 30 94.88 High High
cytokine 10 89.12 High High
cerebral cortex 2 87.60 High High
Hippocampus 4 86.24 High High
midbrain 8 85.20 High High
Spinal cord 1 84.08 Quite High
anesthesia 3 73.20 Quite High
Pain 20 39.40 Quite Low
Disease Link Frequency Relevance Heat
Shock 946 100.00 Very High Very High Very High
Heat Stress Disorders 23 99.98 Very High Very High Very High
Targeted Disruption 27 99.88 Very High Very High Very High
Insulin Resistance 250 99.60 Very High Very High Very High
Diabetes Mellitus 110 99.04 Very High Very High Very High
Cv General 3 Under Development 3 98.80 Very High Very High Very High
Heat Stroke 7 98.20 Very High Very High Very High
Coronary Artery Disease 2 97.56 Very High Very High Very High
Obesity 100 97.44 Very High Very High Very High
Fever 2 97.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results demonstrate that the overexpression of HSP72 in multiple organs improves survival during heatstroke by reducing hyperthermia, circulatory shock, and cerebral ischemia and damage in mice.
Positive_regulation (overexpression) of Gene_expression (overexpression) of HSP72 associated with heat stroke, cv general 4 under development, ischemia, shock and fever
1) Confidence 0.69 Published 2006 Journal J. Appl. Physiol. Section Abstract Doc Link 16627676 Disease Relevance 1.65 Pain Relevance 0.19
HS enhanced the expression of HSP72 in mouse hearts by two- to three-fold, whereas antioxidant enzyme activities (catalase and MnSOD) did not change significantly.
Positive_regulation (enhanced) of Gene_expression (expression) of HSP72 in hearts associated with heat stress disorders
2) Confidence 0.68 Published 1998 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 9925359 Disease Relevance 1.01 Pain Relevance 0.22
To investigate the effect of Hsp72 overexpression, we transfected Hsp72 plasmid in HepG2 cells.
Spec (investigate) Positive_regulation (overexpression) of Spec (investigate) Gene_expression (overexpression) of Hsp72
3) Confidence 0.53 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 0.44 Pain Relevance 0
Consequently, this treatment enhanced the insulin-stimulated Akt phosphorylation in HepG2 cells exposed to high glucose similar to Hsp72 overexpression (Fig. 9D,E).
Positive_regulation (overexpression) of Gene_expression (overexpression) of Hsp72
4) Confidence 0.53 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 0.85 Pain Relevance 0
HS+MES extended the duration of Akt phosphorylation through the increase of Hsp72 expression in HepG2 cells
Positive_regulation (increase) of Gene_expression (expression) of Hsp72 associated with shock
5) Confidence 0.53 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 0.38 Pain Relevance 0
The Akt phosphorylation induced by insulin was enhanced upon Hsp72 overexpression (Fig. 9A,B).
Positive_regulation (overexpression) of Gene_expression (overexpression) of Hsp72
6) Confidence 0.53 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 0.56 Pain Relevance 0
The transgenic mice overexpressing heat shock protein 72 (HSP72) or antioxidants have been reported to be more resistant to myocardial ischemia/reperfusion injury.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of HSP72 associated with targeted disruption, reperfusion injury, coronary artery disease, ischemia and shock
7) Confidence 0.49 Published 1998 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 9925359 Disease Relevance 1.00 Pain Relevance 0.19
Data that corroborate the inducible and constitutive expression of Hspa1a (Hsp70) and Hspa8 (Hsc70), respectively, has been shown by western blot of rat brain regions [91].
Positive_regulation (inducible) of Gene_expression (expression) of Hspa1a in brain
8) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965669 Disease Relevance 0.07 Pain Relevance 0.17
The combination treatment of HS and MES for 10 min increased the Hsp72 expression in protein lysates of HepG2 cells (Fig. 9C) isolated 5 h after treatment.
Positive_regulation (isolated) of Gene_expression (expression) of Hsp72 associated with shock
9) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 0.77 Pain Relevance 0
The Akt phosphorylation induced by insulin was enhanced upon Hsp72 overexpression (Fig. 9A,B).
Positive_regulation (overexpression) of Gene_expression (overexpression) of Hsp72
10) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 0.56 Pain Relevance 0
A recent report suggests that Hsp72 overexpression improved insulin resistance in high fat-fed mice [24].
Positive_regulation (overexpression) of Gene_expression (overexpression) of Hsp72 in fat associated with insulin resistance
11) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 1.10 Pain Relevance 0
Although the core body temperature of the mice was less than 42°C, the method of mild HS that we used was enough to induce the expression of Hsp72 (Fig. 4D).
Positive_regulation (induce) of Gene_expression (expression) of Hsp72 in body associated with shock
12) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 1.33 Pain Relevance 0.14
Hsp72 plasmid, siRNA and transfection
Positive_regulation (transfection) of Gene_expression (transfection) of Hsp72
13) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 0 Pain Relevance 0
To investigate the effect of Hsp72 overexpression, we transfected Hsp72 plasmid in HepG2 cells.
Positive_regulation (transfected) of Gene_expression (transfected) of Hsp72
14) Confidence 0.31 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 0.44 Pain Relevance 0
We hypothetized that unstable angina influences the myocardium, and investigated the expression of the inducible heat shock protein 72 (HSP72), constitutive HSP73, and endothelial nitric oxide synthase (eNOS), and activation of the transcription factors NFkappaB and AP-1 in cardiac tissue.
Spec (investigated) Positive_regulation (activation) of Spec (investigated) Gene_expression (expression) of HSP72 in myocardium associated with angina and shock
15) Confidence 0.16 Published 2000 Journal Cardiovasc. Res. Section Abstract Doc Link 10869529 Disease Relevance 0.53 Pain Relevance 0.26

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