INT79722

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Context Info
Confidence 0.62
First Reported 1998
Last Reported 2010
Negated 4
Speculated 1
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 5.88
Pain Relevance 2.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cat) mitochondrion (Cat) oxidoreductase activity (Cat)
Golgi apparatus (Cat) endoplasmic reticulum (Cat) plasma membrane (Cat)
Anatomy Link Frequency
liver 3
brain 1
internal 1
lungs 1
hearts 1
Cat (Mus musculus)
Pain Link Frequency Relevance Heat
potassium channel 2 98.92 Very High Very High Very High
fibrosis 112 98.76 Very High Very High Very High
qutenza 13 95.12 Very High Very High Very High
ischemia 6 92.00 High High
Paracetamol 22 89.36 High High
Morphine 2 74.32 Quite High
cocaine 2 73.76 Quite High
Analgesic 2 70.68 Quite High
Inflammation 84 69.04 Quite High
anesthesia 7 67.44 Quite High
Disease Link Frequency Relevance Heat
Stress 141 100.00 Very High Very High Very High
Fibrosis 88 99.60 Very High Very High Very High
Pulmonary Fibrosis 58 98.76 Very High Very High Very High
Body Weight 22 98.64 Very High Very High Very High
Heat Stress Disorders 6 97.76 Very High Very High Very High
Hepatotoxicity 17 93.84 High High
Adhesions 5 89.88 High High
Pneumoperitoneum 2 89.12 High High
INFLAMMATION 80 86.80 High High
Poisoning 16 86.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An irreversible inhibitor, 3-amino-1,2,4-triazole (3-AT), was used to modulate catalase activity.
Regulation (modulate) of catalase
1) Confidence 0.62 Published 2002 Journal J. Biochem. Mol. Toxicol. Section Abstract Doc Link 12439864 Disease Relevance 0.22 Pain Relevance 0.58
Staining of alveolar macrophages served as the internal positive control for catalase.
Regulation (control) of catalase in internal
2) Confidence 0.45 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0 Pain Relevance 0
Equally, comparative effects of these plants on lipid peroxidation product thiobarbituric reacting substances (TBARS) and some antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), gluthathione peroxidase (GPx), and delta-aminolevulinate dehydratase (delta-ALA-D) activities, were also evaluated in the mouse liver homogenate.
Regulation (effects) of CAT in liver
3) Confidence 0.44 Published 2008 Journal Exp. Toxicol. Pathol. Section Abstract Doc Link 18054472 Disease Relevance 0.57 Pain Relevance 0.52
Equally, comparative effects of these plants on lipid peroxidation product thiobarbituric reacting substances (TBARS) and some antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), gluthathione peroxidase (GPx), and delta-aminolevulinate dehydratase (delta-ALA-D) activities, were also evaluated in the mouse liver homogenate.
Regulation (effects) of catalase in liver
4) Confidence 0.30 Published 2008 Journal Exp. Toxicol. Pathol. Section Abstract Doc Link 18054472 Disease Relevance 0.57 Pain Relevance 0.52
Involvement of brain catalase activity in the acquisition of ethanol-induced conditioned place preference.
Regulation (Involvement) of catalase in brain
5) Confidence 0.27 Published 2008 Journal Physiol. Behav. Section Title Doc Link 18155096 Disease Relevance 0.07 Pain Relevance 0.20
We first assessed whether the catalase activity is altered in human fibrotic lungs.
Spec (whether) Regulation (altered) of catalase in lungs associated with fibrosis
6) Confidence 0.27 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.42 Pain Relevance 0.09
HS enhanced the expression of HSP72 in mouse hearts by two- to three-fold, whereas antioxidant enzyme activities (catalase and MnSOD) did not change significantly.
Neg (not) Regulation (change) of catalase in hearts associated with heat stress disorders
7) Confidence 0.22 Published 1998 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 9925359 Disease Relevance 0.97 Pain Relevance 0.22
Six experiments were conducted to evaluate the effects of ROS scavengers (superoxide dismutase [SOD], catalase, melatonin, and ascorbic acid), antiinflammatory agents (dexamethasone, tenoxicam, ibuprofen, parecoxib, nimesulide, anti-tumor necrosis factor [TNF]-alpha), and a calcium-channel blocker (diltiazem).
Regulation (effects) of catalase
8) Confidence 0.15 Published 2007 Journal Surg Endosc Section Body Doc Link 17479336 Disease Relevance 0.27 Pain Relevance 0
However, catalase enzyme activity was unchanged in our study, which is in accordance with a CR study (60% of AL) in rats that found no difference in cardiac catalase enzyme activity [52].
Neg (unchanged) Regulation (unchanged) of catalase
9) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0.33 Pain Relevance 0
Furthermore, we hypothesized that CR would: (a) increase antixodant enzymes (MnSOD and Cu/Zn-SOD) and UCP3 as a compensatory mechanism to counteract the increase in oxidative stress, (b) not affect catalase activity since this enzyme is resistant to changes in dietaty intake, (c) increase TNF-?
Neg (not) Regulation (affect) of catalase associated with stress
10) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 1.19 Pain Relevance 0.07
Manganese(II) administration alone decreased the production of thiobarbituric acid reactive substances and exerted no effect on hepatic GSH level and on the activities of antioxidant enzymes – glutathione peroxidase and catalase.
Neg (no) Regulation (effect) of catalase
11) Confidence 0.13 Published 2010 Journal Interdisciplinary Toxicology Section Body Doc Link PMC2984133 Disease Relevance 0.21 Pain Relevance 0
The Cd-induced liver oxidative damage was characterized by an increase in hepatic lipid peroxidation accompanied by a depletion of the main endogenous antioxidant molecule – glutathione, and by the alterations in the activity of antioxidant enzymes – glutathione peroxidase and catalase.
Regulation (alterations) of catalase in liver
12) Confidence 0.13 Published 2010 Journal Interdisciplinary Toxicology Section Body Doc Link PMC2984133 Disease Relevance 0.38 Pain Relevance 0
Treatments effects on ethanol-associated oxidative stress markers GSH, MDA, catalase, SOD, and total nitrate/nitrite levels as an index of NO were measured in gastric tissue.
Regulation (effects) of catalase associated with stress
13) Confidence 0.11 Published 2010 Journal Chem. Biol. Interact. Section Abstract Doc Link 19853593 Disease Relevance 0.16 Pain Relevance 0.14
AAs afforded a dose-related gastroprotection against the ethanol damage and further prevented the ethanol-induced changes in the levels of GSH, MDA, catalase, SOD and nitrate/nitrite.
Regulation (changes) of catalase
14) Confidence 0.11 Published 2010 Journal Chem. Biol. Interact. Section Abstract Doc Link 19853593 Disease Relevance 0.09 Pain Relevance 0.19
Oral gavage administration of benzo(a)pyrene (50 mg/kg body weight) to mice led to a marked increase in oxidative stress indicated by alterations in pulmonary lipid peroxidation, enzymic antioxidants (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione-S-transferase and glucose-6-phosphate dehydrogenase) and non-enzymic antioxidants (reduced glutathione, vitamin C, vitamin E and vitamin A).
Regulation (alterations) of catalase in body associated with stress and body weight
15) Confidence 0.06 Published 2008 Journal Phytother Res Section Abstract Doc Link 18338764 Disease Relevance 0.44 Pain Relevance 0.32

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