INT79723

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Context Info
Confidence 0.70
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 34
Total Number 43
Disease Relevance 24.61
Pain Relevance 3.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sod2) oxidoreductase activity (Sod2) mitochondrion organization (Sod2)
DNA binding (Sod2) response to stress (Sod2) cytoplasm (Sod2)
Anatomy Link Frequency
neuronal 3
gastrocnemius 3
myocardium 2
liver 2
muscle tissues 2
Sod2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 413 99.84 Very High Very High Very High
Paracetamol 17 99.36 Very High Very High Very High
cytokine 127 99.32 Very High Very High Very High
ischemia 68 94.32 High High
Multiple sclerosis 136 94.04 High High
Glutamate 56 93.32 High High
Inflammatory response 70 93.20 High High
Spinal cord 50 87.28 High High
Demyelination 24 86.52 High High
medulla 50 84.48 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 295 100.00 Very High Very High Very High
Mitochondrial Disorders 1 99.92 Very High Very High Very High
INFLAMMATION 505 99.84 Very High Very High Very High
Amyotrophic Sclerosis 4 99.72 Very High Very High Very High
Diabetes Mellitus 168 99.48 Very High Very High Very High
Injury 52 99.44 Very High Very High Very High
Stress 1028 99.32 Very High Very High Very High
Toxicity 137 99.32 Very High Very High Very High
Lifespan 184 98.88 Very High Very High Very High
Death 171 98.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increasing SOD2 levels by viral mediated gene transfer rescued ATP synthesis, suppressed myelin fiber injury and increased retinal ganglion cell survival 1 year later.
Positive_regulation (Increasing) of SOD2 in retinal ganglion cell associated with ganglion cysts and injury
1) Confidence 0.70 Published 2008 Journal Ophthalmic Res. Section Abstract Doc Link 18421242 Disease Relevance 0.91 Pain Relevance 0.15
Collectively, the data suggest that hyperglycemia-induced mitochondrial oxidative stress is a major trigger of diabetes-related neuronal injury that can be ameliorated by increasing SOD2 activity.
Positive_regulation (increasing) of SOD2 in neuronal associated with stress, hyperglycemia, diabetes mellitus and injury
2) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956689 Disease Relevance 1.87 Pain Relevance 0.07
Increasing SOD2 levels twofold in the optic nerve by virally mediated gene transfer ameliorated myelin fiber injury by 51% and RGC loss fourfold, limiting it to 7% in EAE at 1 year.
Positive_regulation (Increasing) of SOD2 in optic nerve
3) Confidence 0.69 Published 2007 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 17251466 Disease Relevance 0.12 Pain Relevance 0
However, the mutant mice maintain the capacity to upregulate SOD2 upon challenge (Tirosh et al. 2005).
Positive_regulation (upregulate) of SOD2
4) Confidence 0.62 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.53 Pain Relevance 0
SOD2 mRNA levels were increased in muscle tissues of Klotho transgenic mice as were SOD2 protein levels (234%) relative to normal mice.
Positive_regulation (increased) of SOD2 in muscle tissues associated with targeted disruption
5) Confidence 0.62 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 1.05 Pain Relevance 0.03
In accordance with the increase in MDA levels, there was a substantial upregulation in antioxidant enzymes, MnSOD (red gastrocnemius, 4-fold; white gastrocnemius, 2.2-fold) and Cu/Zn-SOD (red gastrocnemius, 2.6-fold) in CR vs.
Positive_regulation (upregulation) of MnSOD in gastrocnemius
6) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0.27 Pain Relevance 0
Furthermore, it has been shown that 95 d old G93A mice have significantly elevated levels of MDA (marker of lipid peroxidation) and PC (markers of protein oxidation) in skeletal muscle, as well as a substantial increase in MnSOD, Cu/Zn-SOD and catalase enzyme activity compared with wild-type mice [32].
Positive_regulation (increase) of MnSOD in skeletal muscle
7) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0.30 Pain Relevance 0
On the other hand, six hours and twenty-four hours after an administration of 300 mg/kg acetaminophen, plasma ALT activity was significantly increased in Sod2+/- mice, compared to wild-type mice.
Positive_regulation (increased) of Sod2 in plasma associated with paracetamol
8) Confidence 0.50 Published 2009 Journal Toxicol Pathol Section Abstract Doc Link 19332662 Disease Relevance 0.89 Pain Relevance 0.26
The increase in oxidative stress was accompanied by a substantial upregulation in the protein content of antioxidant enzymes MnSOD and Cu/Zn-SOD in CR vs.
Positive_regulation (upregulation) of MnSOD associated with stress
9) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 1.06 Pain Relevance 0.08
We observe that the increased phosphorylation of p38 MAPK in WT-STZ mice is ameliorated in SOD2-overexpressing mice despite the presence of hyperglycemia.
Positive_regulation (ameliorated) of SOD2 associated with hyperglycemia
10) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956689 Disease Relevance 1.30 Pain Relevance 0
The threshold cycle number for Sod2 gene was normalized to those of the housekeeping genes GAPDH and ribosomal RNA L17.
Positive_regulation (normalized) of Sod2
11) Confidence 0.50 Published 2006 Journal PLoS Genet Section Body Doc Link PMC1358942 Disease Relevance 0.09 Pain Relevance 0
Modest increases in SOD2 are also known to increase lifespan in
Positive_regulation (increases) of SOD2 associated with lifespan
12) Confidence 0.49 Published 2009 Journal PPAR Research Section Body Doc Link PMC2683338 Disease Relevance 1.34 Pain Relevance 0.14
Therefore, even in the event of a baseline signal enhancement in SOD-2 mice, the rate of change of signal intensity, which is representative of axonal transport rates, should not be affected.
Positive_regulation (enhancement) of SOD-2
13) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866668 Disease Relevance 0.18 Pain Relevance 0.08
One possible mechanism for “secondary” induction of MnSOD by Nrf2 activation is the upregulation and nuclear translocation of thioredoxin by Nrf2 [33].
Positive_regulation (induction) of MnSOD
14) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2668769 Disease Relevance 0 Pain Relevance 0.05
In detail, there was a 35% increase in total SOD activity and a 21% increase in MnSOD activity in the Protandim diet group (Figure 3A), which is consistent with the results seen in the human studies [12].
Positive_regulation (increase) of MnSOD
15) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2668769 Disease Relevance 0.14 Pain Relevance 0
The counterpart of catalase in the mitochondria, GPX, is increased in dwarf mouse kidney and liver tissue as is SOD2 (Brown-Borg and Rakoczy 2000 and unpublished data).
Positive_regulation (increased) of SOD2 in liver
16) Confidence 0.42 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.31 Pain Relevance 0
SOD2 mRNA levels were increased in muscle tissues of Klotho transgenic mice as were SOD2 protein levels (234%) relative to normal mice.
Positive_regulation (increased) of SOD2 protein in muscle tissues associated with targeted disruption
17) Confidence 0.42 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 1.07 Pain Relevance 0.04
Such aberrant mitochondrial localization was accompanied by decreased mitochondrial manganese superoxide dismutase (Mn-SOD) activity, cytochrome c release into the cytosol, caspase-3 activation, and DNA fragmentation, most predominantly in hippocampal neuronal cells.
Positive_regulation (activation) of Mn-SOD in neuronal
18) Confidence 0.41 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15644272 Disease Relevance 0.61 Pain Relevance 0.08
This increase is somewhat similar to what we observed in MnSOD protein content upregulation in the white gastrocnemius (2.2-fold) and in Cu/Zn-SOD protein content upregulation in the red gastrocnemius (2.6-fold).
Positive_regulation (upregulation) of MnSOD protein in gastrocnemius
19) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0.17 Pain Relevance 0
Moreover, since basal enzyme activity of MnSOD (4–5-fold), Cu/Zn-SOD (7–10-fold) and catalase (2-fold) are substantially elevated in response to increased basal levels of oxidative stress in G93A mice, any further upregulation in these enzymes may be minimal, and hence may not confer a significant benefit [32].
Positive_regulation (elevated) of MnSOD associated with stress
20) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0.16 Pain Relevance 0

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