INT79725

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Context Info
Confidence 0.61
First Reported 1998
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 4.95
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sod2) oxidoreductase activity (Sod2) mitochondrion organization (Sod2)
DNA binding (Sod2) response to stress (Sod2) cytoplasm (Sod2)
Anatomy Link Frequency
gastrocnemius 1
hearts 1
retinal ganglion cell 1
Sod2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 57 98.64 Very High Very High Very High
cytokine 28 98.12 Very High Very High Very High
ischemia 9 92.00 High High
Spinal cord 5 84.88 Quite High
Kinase C 10 72.88 Quite High
anesthesia 6 66.92 Quite High
Glutamate 9 66.72 Quite High
Neuritis 2 50.00 Quite Low
Deafferentation 19 5.00 Very Low Very Low Very Low
Hippocampus 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 203 99.84 Very High Very High Very High
INFLAMMATION 74 98.64 Very High Very High Very High
Heat Stress Disorders 6 97.50 Very High Very High Very High
Stress 140 96.56 Very High Very High Very High
Death 145 95.92 Very High Very High Very High
Apoptosis 306 94.64 High High
Disease 292 93.80 High High
Drug Induced Neurotoxicity 9 83.68 Quite High
Multiple Sclerosis 2 77.52 Quite High
Experimental Autoimmune Encephalomyelitis 1 77.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The transgene construct that contains the hairpin targeting the Sod2 gene under the control of human ubiquitin C promoter (UbC-SOD2hp-EGFP) has been described previously [13].
Regulation (targeting) of Sod2
1) Confidence 0.61 Published 2006 Journal PLoS Genet Section Body Doc Link PMC1358942 Disease Relevance 1.19 Pain Relevance 0
To confirm the knockdown of Sod2 gene expression, we examined the in vivo consequence of SOD2 deficiency.
Spec (examined) Regulation (consequence) of SOD2
2) Confidence 0.45 Published 2006 Journal PLoS Genet Section Body Doc Link PMC1358942 Disease Relevance 0.32 Pain Relevance 0
Despite the upregulation in the protein content of MnSOD, Cu/Zn-SOD, another potent antioxidant enzyme, was only up-regulated in red gastrocnemius.
Regulation (upregulation) of MnSOD in gastrocnemius
3) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0 Pain Relevance 0
HS enhanced the expression of HSP72 in mouse hearts by two- to three-fold, whereas antioxidant enzyme activities (catalase and MnSOD) did not change significantly.
Neg (not) Regulation (change) of MnSOD in hearts associated with heat stress disorders
4) Confidence 0.33 Published 1998 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 9925359 Disease Relevance 0.97 Pain Relevance 0.22
The knockdown of the Sod2 expression was determined by calculating the fold change of Sod2 in transgenic tissues relative to the wild-type tissues.


Regulation (change) of Sod2 associated with targeted disruption
5) Confidence 0.27 Published 2006 Journal PLoS Genet Section Body Doc Link PMC1358942 Disease Relevance 0.10 Pain Relevance 0
The effects of SOD2 modulation on the EAE optic nerve were gauged by computerized analysis of optic nerve volume, myelin fiber area, and retinal ganglion cell loss at 1, 3, and 12 months after sensitization for EAE.
Regulation (modulation) of SOD2 in retinal ganglion cell
6) Confidence 0.27 Published 2007 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 17251466 Disease Relevance 0.15 Pain Relevance 0
It has been suggested that relocation of FKHs to the cytosol would result in down-regulation of target genes, such as Mn-Superoxide dismutase (MnSOD), thus leading to increased accumulation of reactive oxigen species (ROS), oxidative stress and cell death.
Regulation (regulation) of Mn-Superoxide dismutase associated with stress and death
7) Confidence 0.09 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.85 Pain Relevance 0.04
It has been suggested that relocation of FKHs to the cytosol would result in down-regulation of target genes, such as Mn-Superoxide dismutase (MnSOD), thus leading to increased accumulation of reactive oxigen species (ROS), oxidative stress and cell death.
Regulation (regulation) of MnSOD associated with stress and death
8) Confidence 0.09 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.85 Pain Relevance 0.04
MnSOD is regulated transcriptionally and induced by inflammatory cytokines, including TNF?
Regulation (regulated) of MnSOD associated with inflammation and cytokine
9) Confidence 0.08 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3004876 Disease Relevance 0.51 Pain Relevance 0.25

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