INT7973

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Context Info
Confidence 0.42
First Reported 1989
Last Reported 1999
Negated 3
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.42
Pain Relevance 1.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein modification process (PLOD1) endoplasmic reticulum (PLOD1)
Anatomy Link Frequency
plasma 2
adrenal glands 2
PLOD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 19 100.00 Very High Very High Very High
opiate 4 99.68 Very High Very High Very High
antagonist 2 99.40 Very High Very High Very High
Opioid 4 96.36 Very High Very High Very High
Dismenorea 4 95.52 Very High Very High Very High
Morphine 2 92.28 High High
Endogenous opioid 2 67.64 Quite High
Central nervous system 1 57.68 Quite High
Neuropeptide 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Reprotox - General 1 4 95.52 Very High Very High Very High
Hypertension 1 80.60 Quite High
Stress 1 27.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the postmenopausal period, naloxone has no effect on LH release; estrogen/progestin therapy does restore the LH response.
Positive_regulation (restore) of Regulation (response) of LH associated with narcan
1) Confidence 0.42 Published 1992 Journal Psychoneuroendocrinology Section Abstract Doc Link 1359605 Disease Relevance 0 Pain Relevance 0.28
The pre-medication with captopril significantly enhanced the ACTH and LH response to the opiate antagonist naloxone, but captopril alone did not modify ACTH and LH values when compared to saline.
Positive_regulation (enhanced) of Regulation (response) of LH associated with antagonist, narcan and opiate
2) Confidence 0.39 Published 1993 Journal Horm. Metab. Res. Section Abstract Doc Link 8262463 Disease Relevance 0.08 Pain Relevance 0.92
On the other hand, oCRH administration did not result in any significant alteration in either basal or NAL-stimulated LH levels.
Neg (not) Positive_regulation (result) of Regulation (alteration) of LH associated with narcan
3) Confidence 0.39 Published 1997 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 9024279 Disease Relevance 0 Pain Relevance 0.28
Our results clearly indicate that in the primate the adrenal glands are not required for the acute CRH inhibitory effect on LH and FSH, and consequently, the decrease in gonadotropins that follows CRH is not mediated by the resultant increase in cortisol release, but, rather, by central mechanisms.
Neg (not) Positive_regulation (required) of Regulation (effect) of LH in adrenal glands
4) Confidence 0.19 Published 1989 Journal Endocrinology Section Abstract Doc Link 2494035 Disease Relevance 0 Pain Relevance 0.17
Pregnanolone did not induce any changes in estradiol, LH, FSH or prolactin plasma levels in either cycle phase.
Neg (not) Positive_regulation (induce) of Neg (not) Regulation (changes) of LH in plasma
5) Confidence 0.16 Published 1999 Journal Gynecol. Endocrinol. Section Abstract Doc Link 10599553 Disease Relevance 0.34 Pain Relevance 0.34

General Comments

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