INT79737

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Context Info
Confidence 0.49
First Reported 1999
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 12
Total Number 13
Disease Relevance 3.98
Pain Relevance 6.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk1) endosome (Ntrk1) aging (Ntrk1)
plasma membrane (Ntrk1) cytoplasm (Ntrk1)
Anatomy Link Frequency
neurons 2
spinal 1
TMJ 1
motoneurons 1
neural 1
Ntrk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bDMF 229 100.00 Very High Very High Very High
Trk A 9 100.00 Very High Very High Very High
Pain 12 99.60 Very High Very High Very High
nociceptor 6 99.60 Very High Very High Very High
agonist 5 99.56 Very High Very High Very High
intrathecal 1 99.56 Very High Very High Very High
Hsan 5 99.44 Very High Very High Very High
nMDA receptor 2 98.96 Very High Very High Very High
Kappa opioid receptor 7 98.92 Very High Very High Very High
Nerve growth factor 19 98.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 8 99.44 Very High Very High Very High
Hereditary Sensory And Autonomic Neuropathies 6 99.44 Very High Very High Very High
Nervous System Injury 20 99.04 Very High Very High Very High
Manic Depressive Disorder 125 98.28 Very High Very High Very High
Nociception 5 95.28 Very High Very High Very High
Injury 39 91.64 High High
Neuropathic Pain 5 89.92 High High
Spinal Cord Injury 37 89.20 High High
Sciatic Neuropathy 32 85.80 High High
Tooth Injuries 2 81.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results show that, in rat hypothalamic cultures, brain-derived neurotrophic factor, and NT-3 have a potent stimulatory effect on peptide synthesis in somatostatinergic neurons, likely through direct activation of TrkB and TrkC receptors.
Positive_regulation (activation) of Trk in neurons
1) Confidence 0.49 Published 1999 Journal Endocrinology Section Abstract Doc Link 9927323 Disease Relevance 0 Pain Relevance 0.54
As a whole, these results corroborate the evidence indicating a key role of the BDNF/Trk signaling pathway in lithium response and BD.
Positive_regulation (role) of Trk associated with manic depressive disorder and bdmf
2) Confidence 0.49 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.64 Pain Relevance 0.13
Thus our results suggest that NGF may be mediating repair and pain responses by the sustained upregulation of its cell surface receptor, trk A, in neurons of the trigeminal ganglia.
Positive_regulation (upregulation) of trk A in neurons associated with pain, nerve growth factor and trk a
3) Confidence 0.49 Published 2000 Journal J Endod Section Abstract Doc Link 11194379 Disease Relevance 0.69 Pain Relevance 0.63
They protect neurons from degeneration and promote regeneration of injured nerve and enhance differentiation of neural stem cells by activating tyrosine kinase receptors (trk) and the down-stream signal pathways [3], [4], [5].
Positive_regulation (activating) of trk in neural
4) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2246162 Disease Relevance 0.23 Pain Relevance 0.33
This CCI-induced CB1R upregulation was at least in part mediated through tyrosine kinase receptors (Trk), because intrathecal treatment with the Trk inhibitor K252a (1 microg) for postoperative days 1-6 significantly reduced the CB1R upregulation in CCI rats.
Positive_regulation (mediated) of Trk associated with nervous system injury and intrathecal
5) Confidence 0.37 Published 2003 Journal Pain Section Abstract Doc Link 14499445 Disease Relevance 1.09 Pain Relevance 0.78
Our report increases the spectrum of NTRK1 mutations in CIPA patients and describes an unusual case of a cluster of four mutations located close to each other in one exon.
Positive_regulation (increases) of NTRK1 associated with hsan
6) Confidence 0.33 Published 2001 Journal Hum. Mutat. Section Abstract Doc Link 11139246 Disease Relevance 0.53 Pain Relevance 0.34
This action involves activation of the tyrosine kinase receptor (Trk) A/p38 MAPK pathway.
Positive_regulation (activation) of Trk
7) Confidence 0.31 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16283857 Disease Relevance 0.25 Pain Relevance 0.28
Since fluoxetine treatment is required for at least 14 days to increase progenitor cell mitosis rates, we asked whether activation of Trk receptors was required for the whole of this period.
Positive_regulation (activation) of Trk associated with fluoxetine
8) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965105 Disease Relevance 0 Pain Relevance 1.00
It should be noted that few of these inhibitors are Trk selective, demonstrating that targeting Trk kinases for treatment of pain and/or cancer offers a promising but also challenging approach.


Positive_regulation (targeting) of Trk
9) Confidence 0.14 Published 2009 Journal Expert Opin Ther Pat Section Body Doc Link 19441906 Disease Relevance 0.15 Pain Relevance 0
At synapses on motoneurons trk receptor activation enhances the response of NMDA receptors that in turn can increase the response of AMPA/kainate receptors on the same cell.
Positive_regulation (activation) of trk receptor in motoneurons associated with nmda receptor
10) Confidence 0.11 Published 2002 Journal Brain Res. Brain Res. Rev. Section Abstract Doc Link 12589921 Disease Relevance 0.10 Pain Relevance 0.34
Co-injection of the non-specific Trk receptor antagonist k252A with NGF 1 h after the TMJ injection of carrageenan significantly reduced NGF-induced spontaneous nociception supporting the Trk receptor activation in this nociceptive effect.
Positive_regulation (activation) of Trk receptor in TMJ
11) Confidence 0.10 Published 2008 Journal Life Sci. Section Body Doc Link 18930742 Disease Relevance 0.14 Pain Relevance 0
These results indicate that TRK-820 acts as a full agonist for the kappa-opioid receptor, a partial agonist for the mu-opioid receptor and a low-affinity antagonist for the nociceptin receptor.
Spec (partial) Positive_regulation (acts) of TRK-820 associated with orphanin, antagonist, kappa opioid receptor, agonist and opioid receptor
12) Confidence 0.10 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10440101 Disease Relevance 0 Pain Relevance 0.95
Noxious stimulation induces Trk receptor and downstream ERK phosphorylation in spinal dorsal horn.
Positive_regulation (induces) of Trk in spinal associated with nociceptor and spinal dorsal horn
13) Confidence 0.06 Published 2002 Journal Mol. Cell. Neurosci. Section Title Doc Link 12504600 Disease Relevance 0.16 Pain Relevance 0.92

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