INT7974

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Context Info
Confidence 0.42
First Reported 1982
Last Reported 2009
Negated 1
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 0.41
Pain Relevance 1.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein modification process (PLOD1) endoplasmic reticulum (PLOD1)
Anatomy Link Frequency
Plasma 2
follicle 2
pituitary 2
PLOD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 32 100.00 Very High Very High Very High
Buprenorphine 6 99.98 Very High Very High Very High
agonist 74 99.86 Very High Very High Very High
tolerance 4 99.64 Very High Very High Very High
central nervous system 1 98.52 Very High Very High Very High
Endogenous opioid 1 96.64 Very High Very High Very High
Clonidine 1 92.64 High High
antagonist 95 91.60 High High
opiate 4 83.84 Quite High
Narcan 4 65.92 Quite High
Disease Link Frequency Relevance Heat
Aging 44 86.52 High High
Lifespan 6 83.88 Quite High
Reprotox - General 2 70 60.84 Quite High
Reprotox - General 3 77 50.00 Quite Low
Syndrome 10 42.88 Quite Low
Congenital Anomalies 17 38.64 Quite Low
Apoptosis 7 33.52 Quite Low
Disease 14 17.44 Low Low
Reprotox - General 1 35 5.00 Very Low Very Low Very Low
Diabetes Mellitus 29 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tolerance to buprenorphine effects on LH and prolactin levels did not occur during chronic drug administration.
Regulation (effects) of Gene_expression (levels) of LH associated with tolerance and buprenorphine
1) Confidence 0.42 Published 1982 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7057390 Disease Relevance 0 Pain Relevance 1.09
Through a feedback mechanism, they influence the synthesis and release of hypothalamic gonadotropin-releasing hormone (GnRH) and/or pituitary gonadotropic hormones (luteinizing hormone, LH, and follicle stimulating hormone, FSH).
Regulation (influence) of Gene_expression (synthesis) of LH in follicle
2) Confidence 0.41 Published 1992 Journal Psychoneuroendocrinology Section Abstract Doc Link 1359605 Disease Relevance 0 Pain Relevance 0.21
Plasma levels of PRL, FSH and LH were unaffected by the drug.
Neg (unaffected) Regulation (unaffected) of Gene_expression (levels) of LH in Plasma
3) Confidence 0.19 Published 1988 Journal Acta Endocrinol. Section Abstract Doc Link 2901180 Disease Relevance 0 Pain Relevance 0.22
Unexpectedly, PRLR mRNA expression in the macaque CL was down-regulated by LH withdrawal.
Regulation (regulated) of Gene_expression (withdrawal) of LH associated with withdrawal
4) Confidence 0.15 Published 2009 Journal Molecular Human Reproduction Section Body Doc Link PMC2647108 Disease Relevance 0 Pain Relevance 0.20
There are changes in the lutenising hormone (LH) production which consist of decreased LH pulse frequency and amplitude, (Veldhuis et al 1992; Pincus et al 1997) although pituitary production of LH in response to pharmacological stimulation with exogenous GnRH analogues is preserved (Mulligan et al 1999).
Regulation (changes) of Gene_expression (production) of LH in pituitary
5) Confidence 0.12 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2544367 Disease Relevance 0.33 Pain Relevance 0
Because insulin and hCG may share common pathways beyond but not at the level of receptor activation, we hypothesize that in-vivo GnRH agonist might affect the expression and/or activation of LH receptors.
Spec (might) Regulation (affect) of Gene_expression (expression) of LH associated with agonist
6) Confidence 0.09 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0 Pain Relevance 0.27
Effect on LH surge
Regulation (Effect) of Gene_expression (surge) of LH
7) Confidence 0.08 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0.08 Pain Relevance 0

General Comments

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