INT79748

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Context Info
Confidence 0.03
First Reported 1999
Last Reported 2008
Negated 1
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 1.28
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (RUNX1) nucleus (RUNX1) DNA binding (RUNX1)
transcription factor binding (RUNX1)
RUNX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 20 99.92 Very High Very High Very High
Clonidine 3 99.18 Very High Very High Very High
antagonist 2 98.00 Very High Very High Very High
Pain 2 5.00 Very Low Very Low Very Low
Piles 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myeloid Leukemia 9 100.00 Very High Very High Very High
Myeloproliferative Disorder 2 97.56 Very High Very High Very High
Neutropenia 13 90.32 High High
Neutrophil Disorders 4 80.16 Quite High
Syndrome 3 75.60 Quite High
Disease 6 73.84 Quite High
Myelodysplastic Syndromes 7 69.28 Quite High
Stress 1 66.72 Quite High
Apoptosis 1 57.36 Quite High
Monosomy 14 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, considering the low incidence of GSD-1b, neither an increased intrinsic risk for AML nor an association between G-CSF treatment and evolution of myeloid neoplasms has been noted so far [6].
Neg (neither) Positive_regulation (increased) of AML associated with myeloproliferative disorder and myeloid leukemia
1) Confidence 0.03 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2566578 Disease Relevance 1.28 Pain Relevance 0
Activation of this fusion protein in CHO-K1 cells by (-)-adrenaline induced a time- and concentration-dependent (pEC50: 7.28+/-0.04) increase in the intracellular Ca2+ concentration.
Positive_regulation (Activation) of fusion protein
2) Confidence 0.03 Published 2000 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 10882043 Disease Relevance 0 Pain Relevance 0.18
Moreover, although clonidine functioned as a good partial agonist to activate the fusion protein containing Cys351Gi1alpha, it was essentially an antagonist at the Gly351Gi1alpha-containing fusion protein.
Spec (partial) Positive_regulation (activate) of fusion protein associated with antagonist, agonist and clonidine
3) Confidence 0.02 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 9927608 Disease Relevance 0 Pain Relevance 0.45
By contrast, incorporation of Ile351Gi1alpha into the fusion protein resulted in all partial agonists displaying higher intrinsic activity relative to epinephrine to activate this fusion protein than the one containing the wild-type G protein sequence.
Positive_regulation (activate) of fusion protein associated with agonist
4) Confidence 0.02 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 9927608 Disease Relevance 0 Pain Relevance 0.46

General Comments

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