INT7975

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Context Info
Confidence 0.62
First Reported 1981
Last Reported 2010
Negated 35
Speculated 5
Reported most in Abstract
Documents 97
Total Number 102
Disease Relevance 20.90
Pain Relevance 30.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein modification process (PLOD1) endoplasmic reticulum (PLOD1)
Anatomy Link Frequency
plasma 10
follicle 4
pituitary 4
sella 2
adrenal glands 2
PLOD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 254 100.00 Very High Very High Very High
antagonist 249 100.00 Very High Very High Very High
agonist 203 100.00 Very High Very High Very High
opiate 57 100.00 Very High Very High Very High
Enkephalin 15 100.00 Very High Very High Very High
opioid receptor 14 100.00 Very High Very High Very High
Morphine 13 100.00 Very High Very High Very High
Buprenorphine 12 100.00 Very High Very High Very High
aspirin 6 100.00 Very High Very High Very High
Opioid 66 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anovulation 24 100.00 Very High Very High Very High
Hypoglycemia 7 100.00 Very High Very High Very High
Reprotox - General 3 285 99.92 Very High Very High Very High
Endometriosis (extended) 229 99.80 Very High Very High Very High
Fibromyalgia 77 99.28 Very High Very High Very High
Empty Sella Syndrome 3 99.28 Very High Very High Very High
Delayed Puberty 25 99.00 Very High Very High Very High
Stress 40 98.92 Very High Very High Very High
Reprotox - General 2 51 98.76 Very High Very High Very High
Precocious Puberty 9 98.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study examined the acute effects of injections of morphine and naloxone on plasma LH levels in 30 healthy subjects (18 women and 12 men).
Spec (examined) Regulation (effects) of LH in plasma associated with narcan and morphine
1) Confidence 0.62 Published 1986 Journal Life Sci. Section Abstract Doc Link 3086650 Disease Relevance 0.15 Pain Relevance 0.77
Melatonin did not affected LH serum levels, while it was able to reduce LH increase induced by naloxone.
Neg (not) Regulation (affected) of LH associated with narcan
2) Confidence 0.59 Published 1988 Journal J. Endocrinol. Invest. Section Abstract Doc Link 3361078 Disease Relevance 0 Pain Relevance 0.71
To evaluate the possible involvement of endogenous opioid peptides in the responses of PRL, LH, and cortisol to surgical stress, we have studied the effect of naloxone on these hormones in otherwise normal subjects of both sexes undergoing cholecystectomy for gallstones.
Spec (possible) Regulation (responses) of LH associated with stress, narcan, endogenous opioid and gallstones
3) Confidence 0.57 Published 1982 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7085859 Disease Relevance 0.27 Pain Relevance 0.35
Effects of buprenorphine on LH and prolactin levels are more consistent with the actions of opiate agonists rather than opiate antagonists.
Regulation (Effects) of LH associated with antagonist, agonist, opiate and buprenorphine
4) Confidence 0.57 Published 1982 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7057390 Disease Relevance 0 Pain Relevance 1.15
On the other hand, oCRH administration did not result in any significant alteration in either basal or NAL-stimulated LH levels.
Regulation (alteration) of LH associated with narcan
5) Confidence 0.51 Published 1997 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 9024279 Disease Relevance 0 Pain Relevance 0.28
This experimental model is predicted to have a beta-error of less than 0.10 for identifying a 1.0 U/L change in LH levels.
Regulation (change) of LH
6) Confidence 0.51 Published 1997 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 9024279 Disease Relevance 0 Pain Relevance 0.35
In postmenopausal women not subjected to any treatment, dermorphin infusion did not significantly modify plasma LH and FSH levels.
Neg (not) Regulation (modify) of LH in plasma
7) Confidence 0.50 Published 1985 Journal Peptides Section Abstract Doc Link 3936026 Disease Relevance 0 Pain Relevance 0.29
The lowest dose (6 micrograms/kg) caused no change in serum LH and FSH.
Neg (no) Regulation (change) of LH
8) Confidence 0.46 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3008020 Disease Relevance 0 Pain Relevance 0.49
There was no difference in LH, follicle-stimulating hormone, or testosterone concentrations in both groups.
Neg (no) Regulation (difference) of LH in follicle
9) Confidence 0.44 Published 1993 Journal J. Androl. Section Abstract Doc Link 8294223 Disease Relevance 0.35 Pain Relevance 0.19
No change in either mean basal LH or in the LH pulsatility parameters was found.
Neg (No) Regulation (change) of LH
10) Confidence 0.44 Published 1996 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8675571 Disease Relevance 0 Pain Relevance 0.32
Plasma levels of PRL, FSH and LH were unaffected by the drug.
Neg (unaffected) Regulation (unaffected) of LH in Plasma
11) Confidence 0.43 Published 1988 Journal Acta Endocrinol. Section Abstract Doc Link 2901180 Disease Relevance 0 Pain Relevance 0.22
The purpose of this study was to evaluate the effects of dermorphin, a new synthetic powerful opiate-like heptapeptide, on plasma luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels in fertile and postmenopausal women.
Regulation (effects) of LH in plasma associated with opiate
12) Confidence 0.42 Published 1985 Journal Peptides Section Abstract Doc Link 3936026 Disease Relevance 0 Pain Relevance 0.20
Infusion of naloxone (2-mg bolus plus 2 mg/h or 10-mg bolus plus 10 mg/h) did not reverse the effects of insulin-induced hypoglycemia on LH concentrations.
Neg (not) Regulation (effects) of LH associated with hypoglycemia and narcan
13) Confidence 0.42 Published 1993 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8388404 Disease Relevance 0.59 Pain Relevance 0.56
Endotoxin could alter circulating concentrations of LH via actions at the hypothalamus through altered GnRH production and/or release, or endotoxin could alter circulating concentrations of LH at the level of the pituitary via inhibition of LH production and release or inhibition of LH in response to GnRH.
Regulation (alter) of LH in pituitary
14) Confidence 0.42 Published 2003 Journal Domest. Anim. Endocrinol. Section Abstract Doc Link 12963096 Disease Relevance 0.06 Pain Relevance 0.12
In this study, we examine the ability of longer term opioid antagonism during the luteal phase to alter pulsatile LH and PRL release.
Regulation (alter) of LH associated with opioid
15) Confidence 0.41 Published 1988 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 3129443 Disease Relevance 0 Pain Relevance 0.63
Compared with the placebo, fluoxetine elicited no changes in 24 h mean serum LH concentrations, LH pulse characteristics (Cluster analysis), or LH secretion and clearance parameters assessed in response to exogenous GnRH administration (deconvolution analysis) in the presence of normal opiatergic tone (nine healthy young men), and during acute blockade of the opiatergic system (seven young men treated with the mu-opiate receptor antagonist, naltrexone).
Neg (no) Regulation (changes) of LH associated with antagonist, opiate and fluoxetine
16) Confidence 0.40 Published 1990 Journal J. Androl. Section Abstract Doc Link 2166728 Disease Relevance 0 Pain Relevance 0.58
Naloxone had no effect on serum LH or FSH before or during the pulsatile administration.
Neg (no) Regulation (effect) of LH associated with narcan
17) Confidence 0.40 Published 1987 Journal Acta Endocrinol. Section Abstract Doc Link 3101337 Disease Relevance 0.13 Pain Relevance 0.17
The present work was designed to evaluate the acute effect of the prostaglandin blocker aspirin on plasma LH response to the opiate antagonist naloxone or GnRH in normal volunteers in a placebo-controlled, single-blind study.
Regulation (effect) of LH in plasma associated with aspirin, antagonist, narcan and opiate
18) Confidence 0.39 Published 1996 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8626832 Disease Relevance 0 Pain Relevance 0.53
However, the LHRH-induced rise in LH and FSH in young male volunteers was unaffected by pretreatment with a high-dose DAMME infusion.
Neg (unaffected) Regulation (unaffected) of LH
19) Confidence 0.39 Published 1981 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 6784982 Disease Relevance 0.16 Pain Relevance 0.61
The opioid control of LH and FSH release: effects of a met-enkephalin analogue and naloxone.
Regulation (control) of LH associated with narcan, enkephalin and opioid
20) Confidence 0.39 Published 1981 Journal Clin. Endocrinol. (Oxf) Section Title Doc Link 6784982 Disease Relevance 0.16 Pain Relevance 0.79

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