INT79754

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Context Info
Confidence 0.48
First Reported 1998
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.59
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Galr2) signal transducer activity (Galr2)
Anatomy Link Frequency
spinal 1
M15 1
Galr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 5 98.80 Very High Very High Very High
amygdala 1 97.16 Very High Very High Very High
Hippocampus 2 96.64 Very High Very High Very High
Raphe 1 95.56 Very High Very High Very High
substantia gelatinosa 2 90.72 High High
Spinal cord 2 82.96 Quite High
Locus ceruleus 1 81.68 Quite High
antagonist 1 77.52 Quite High
Pain 3 75.00 Quite High
Action potential 1 30.16 Quite Low
Disease Link Frequency Relevance Heat
Nociception 3 99.70 Very High Very High Very High
Status Epilepticus 1 87.84 High High
Pain 2 75.00 Quite High
Convulsion 2 75.00 Quite High
Cognitive Disorder 1 59.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Galanin modulates spinal nociceptive processing by interacting with two receptors, GalR1 and GalR2.
GalR2 Binding (interacting) of in spinal associated with nociception
1) Confidence 0.48 Published 2008 Journal Pain Section Abstract Doc Link 17910903 Disease Relevance 0.17 Pain Relevance 0.23
We speculate that the GalR2/3 binding sites detected by galanin (2-11) binding in our study probably represent mostly GalR2 receptors.
GalR2 Binding (binding) of
2) Confidence 0.33 Published 2005 Journal Neuropeptides Section Abstract Doc Link 15944003 Disease Relevance 0.34 Pain Relevance 0.29
Rat galanin and galanin-related peptides M40, C7, M15, and galanin effectively competed for binding; peptide C7 demonstrated a lower affinity for rGALR-2, and all these peptides were agonists at rGALR-2 when assessed on a microphysiometer.
rGALR-2 Binding (affinity) of in M15 associated with agonist
3) Confidence 0.31 Published 1998 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 9928164 Disease Relevance 0.07 Pain Relevance 0.20

General Comments

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